Description overdue on 10/12/2014
- Latin name: Leukeran
- ATC code: L01AA02
- Active substance: Chlorambucil (Chlorambucil)
- Manufacturer: Trading GlaxoSmithKline (Glaxo Wellcome Operations), Germany.
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications for use of the drug
- Contraindications
- Side effects
- Instructions on Leykeran (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Special conditions
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
In tablets, coated tablets, the active ingredient is contained: chlorambucil.
Auxiliary ingredients: colloidal anhydrous silica and lactose anhydrous, stearic acid, MCC, Opadry brown, titanium dioxide, iron oxide yellow and red, hypromellose, macrogol.
Product form
Leykeran release tablets circular shape, coated brown shell, biconcave with engravings - L on the one hand, and on the other - GX EG3.
Pharmacological action
The drug has cytostatic, antitumoral action.
Pharmacodynamics and pharmacokinetics
Chlorambucil It represents an aromatic nitrogen mustard derivative, so the treatment bifunctional alkylating manifests its action. Alkylation is carried out through the formation of highly active radicals etilenimoniuma . This results in cross-linking between the radicals etilenimoiiuma and helix DNA, which leads to destruction of its replication process.
It noted the good absorption of the drug from the gastrointestinal tract. The maximum concentration of active ingredient is achieved after 30 minutes - 2 hours from the time of reception. Plasma protein binding is 99%. Withdrawal chlorambucil from the plasma occurs after about 1 5 hours.
The substance is metabolized in the liver, and the whole process takes place quickly and fully. The drug is excreted primarily derived using the kidneys as metabolites. There was no penetration of substances through the BBB, but it easily passes through the placental barrier.
Indications for use of the drug
Leukeran drug is indicated for:
- chlamydia - Hodgkin's disease;
- chronic lymphocytic leukemia;
- malignant lymphomas, eg , Lymphosarcoma;
- Waldenstrom's macroglobulinemia.
Contraindications
Not recommended for use when Leykeran:
- lactation, pregnancy;
- hypersensitivity to the drug.
Use caution is necessary during treatment of patients with:
- suppression of bone marrow function, when expressed leukopenia, and thrombocytopenia;
- varicella Diagnosed or recently transferred;
- herpes zoster;
- acute infectious diseases of viral, bacterial and fungal origin;
- tumor infiltration of bone marrow cells;
- gout ;
- nefrourolitiazom urate;
- head trauma, epilepsy;
- severe liver disease and kidney failure.
Side effects
Treatment leukeran may be accompanied by: myelosuppression , Gastrointestinal disorders, disorders of the liver, jaundice , Skin rash, fever, peripheral neuropathy . pneumonia, aseptic cystitis, seizures, amenorrhea and so on.
Instructions on Leykeran (method and dosage)
These tablets are intended for ingestion in general form. Usually Leykeran consist of combination therapy, so the selection and dosing regime is performed using competent specialist.
Guide to the drug reports that in the period of treatment Hodgkin's disease adult and young patients can be carried monotherapy, assuming average daily reception 0, 2 mg per kg. The therapeutic course of 4-8 weeks.
In other cases, the dose calculation is performed according to the weight and the individual patient. The duration of treatment is determined by a specialist.
Overdose
In cases of overdose can occur: irritability, reversible pancytopenia , Repeated epileptic seizures . ataxia .
The specific antidote is not established.
It is necessary to wash out the stomach, inspect and maintain the vital functions of the body, blood tests to monitor and carry out all required procedures according to the symptoms manifested.
Cooperation
The simultaneous use of drugs, the ability to inhibit the formation of blood, can enhance myelotoxicity.
Combination with arthrifuge requires correction of the dose, since chlorambucil increases the concentration of uric acid in the blood.
In simultaneous treatment and leukeran tricyclic aitidepressantami . haloperidol, maprotiline . monoamine oxidase inhibitors, phenothiazines, thioxanthenes often lowers the threshold for seizure activity and increases the risk of seizures.
Combination therapy with and naktivirovannymi viral vaccines reduces the production of antibodies in response to the entered vaccine; from live viral vaccines It can cause increased side effects, reduced antibody production, and other undesirable effects.
Terms of sale
The drug prescription.
Storage conditions
For storage Leykerana need a dark place, away from children at a temperature of 2-8 C.
Shelf life
3 years.
Special conditions
When treating leukeran control is required blood tests, kidney or liver functions. Treatment of bone marrow hypoplasia requires compliance with the daily dose, which should not be higher than 0, 1 mg / kg. During the treatment of chronic lymphocytic leukemia When patients have symptoms of bone marrow failure, first take prednisolone . Reducing the number of neutrophils did not require discontinuation of treatment, but it should be borne in mind that over the 10 days of discontinuing treatment process can continue.
When patients suffer from severe liver problems, you need to carry out a reduction of dosage. Reduced renal excretory function requires strict surveillance, as there is likely to develop further myelodepression Induced azotemia .
Analogs
The main counterparts are presented Leykerana drugs: Chlorambucil and Hlorbutin .
Alcohol
Drinking alcohol while taking this drug increases the risk of stomach bleeding and other disorders.
Reviews leukeran
The network meets many discussions somehow associated with the drug. As the reviews of leukeran, its effectiveness can not be in doubt. However, many people are faced with the problem of the acquisition of this medication. Therefore, the forums can meet users' questions: where to buy Leykeran when will be available? In addition, there are messages that offer to order it from Germany.
However, in Russia it means already available in some Internet or conventional pharmacies. It is known that the drug has a high cost, and if we look at private ads "selling Leykeran" you can easily buy a fake. For this reason, it is necessary to buy the drug only in specialized areas.
Price Leykerana. Where to buy Leykeran in Moscow
In Russia Leykeran buy in pharmacies is very difficult, as it often is not available. Can serve as an alternative to an online pharmacy. In addition, the tablet is always available in the official pharmaceutical organizations or on their website.
Price Leykerana in Moscow is 2800-3100 rubles. In other cities, for example, in St. Petersburg, the drug is almost the same. In remote regions, for example, in Novosibirsk, Omsk and its price ranges 3000-3200 rubles.
The price of the drug in the Ukraine, in cities such as Kiev, Kharkov and Dnepropetrovsk, is 650-1200 USD., Depending on the number of tablets in the package.
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