Olfen 100

Description overdue on 10/13/2014

• Latin name: Olfen-100
• ATC code: M01AB05
• Active substance: Diclofenac sodium (Diclofenac sodium)
• Manufacturer: Mephala LLC (Switzerland)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Olfen 100 Average Depokaps (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Reviews
• Price, where to buy

Composition

Active substance - diclofenac sodium .

Auxiliary ingredients: lactose, sodium carboxymethyl cellulose, microcrystalline cellulose, titanium dioxide, trietilatsetat, MCC trimyristate glycerol, ammonium methacrylate copolymer dispersion of type B gelatin, aqueous colloidal silica, iron oxide black, erythrosine, iron oxide red.

Product form

The medicine is available in capsule form prolonged   action.

Pharmacological action

The drug is anti-inflammatory . antipyretic   and analgesic   agent.

Pharmacodynamics and pharmacokinetics

At the heart of the action of the drug - preventing biosynthesis of prostaglandins That influence inflammation, fever and pain.

At rheumatic   diseases Olfen 100 helps reduce the severity of pain at rest and in motion, to improve the work of the joints, swelling to remove them, as well as to eliminate the morning stiffness. When the pain after injuries and operations, it also reduces the sensation of movement, wound edema and inflammatory swelling.

When primary dysmenorrhea   the drug reduces pain and intensity of menstruation.

After a single use of the maximum concentration - 4 hours. Meals do not have a significant effect on bioavailability   and the degree of Absorption this tool.

The binding of the active substance to plasma proteins - almost 100%. Mainly diclofenac   binds albumin . He enters the synovial fluid . The active substance reaches it maximum concentration of approximately 3 hours later than in plasma. The half-life of synovial fluid -   about 4-5 hours. Contents synovial fluid   It remains at a high level, and within 12 hours after ingestion of the drug.

Biotransformation   the active substance is carried out by glucuronidation   unmodified molecule, methoxylation   and hydroxylation   to form phenolic metabolites Which are then converted to glucuronide conjugates .

The final half-life of 1-2 hours. The half-life metabolites   - About 2 hours. 60% of the drug is excreted in the urine in the form metabolites . About 1% is excreted unchanged.

Indications

The drug is used in chronic polyarthritis . arthrosis . tendovaginitah . sciatica , Pain and inflammation in gynecology, arthritis . bursits . lumbago . cervical syndrome , Pain and swelling after injuries and operations.

Contraindications

Among the contraindications to the use of capsules, the following:

• Crohn's disease   or ulcerative colitis ;
• Hypersensitivity to the drug;
• pregnancy   (III trimester);
• hives   and rhinitis   because of the application NSAIDs ;
• heart failure ;
• peptic ulcer   stomach and duodenum;
• renal failure   in severe;
• the presence of seizures aspirin asthma   at history ;
• hepatic failure   in severe;
• increased risk of bleeding after surgery, cerebrovascular bleeding , Part-time homeostasis , Violations hematopoiesis .

It is also should not be applied to children   due to the high content of the active component.

Side effects

When you receive this drug may experience the following side effects:

• CNS - appearance dizziness . headache ;
• hearing - vertigo ;
• Gastrointestinal - nausea, diarrhea . dyspepsia . anorexia , Vomiting, abdominal cramps, flatulence , Pain in the abdomen;
• hepatobiliary system : Increased transaminases ;
• Leather - the appearance of rash;
• kidney and urinary tract - fluid retention, arterial hypertension . swelling .

In rare cases, as observed by:

• blood and lymphatic system - thrombocytopenia . anemia . leukopenia . agranulocytosis ;
• Nervous System - aseptic meningitis , Disorientation, insomnia , Irritability, depression , Nightmares, psychotic disorders, drowsiness , Violation of the sensitivity of the skin, convulsions, tremor , Taste disturbances and cerebral circulation, memory disorders, alarm ;
• organs of vision - diplopia , Blurred vision;
• CCC - chest pain, vasculitis , Tachycardia, heart failure . myocardial infarction . arterial hypertension ;
• respiratory system - bronchospasm . asthma . pneumonitis ;
• hepatobiliary system - liver dysfunction, hepatitis . jaundice . necrosis   liver hepatic failure ;
• kidney and urinary tract - proteinuria . nephrotic syndrome , Acute renal failure . hematuria . interstitial nephritis . necrotizing papillitis ;
• the immune system - hypersensitivity anaphylactoid   and anaphylactic   reaction angioedema ;
• hearing - hearing loss, ringing in the ears;
• GIT - gastritis , Bleeding in the gastrointestinal tract, melena , Ulcers of the stomach and intestines, colitis . stomatitis , Esophageal, pancreatitis . constipation . glossitis . diafragmopodobnye bowel stricture ;
• skin - toxic epidermal necrolysis . hives . erythema . exfoliative dermatitis . Stevens-Johnson syndrome . photosensitization . eczema , hair loss, purpura .

In applying the drug at high doses and for a long period of time may cause Arterial thromboembolic events .

Instructions for use Olfen 100 Average Depokaps (method and dosage)

Instructions for capsules reports that initial daily dosage for adult patients is generally 100-150 mg. However, in mild cases, it may be 50 mg. All dosage divided by 2-3 times. Capsules guide advises to take before meals with water and without chewing.

The precise dosage and dosage regimen and the duration must be selected specialist individually   for each patient.

For example, when primary dysmenorrhea   initial dose is typically 50 mg. During treatment, if necessary, it can rise to a maximum daily - 200 mg.

It is possible to combine the reception means of other forms, for example, concurrently receive Olfen tablets, suppositories, plaster and so on. D. But the maximum daily dose should not be greater than with the 150 mg.

Overdose

Typical symptoms of overdose are not established. When applying caps in excess of the norm, it is possible vomiting . diarrhea . noise in ears . bleeding in the gastrointestinal tract . dizziness . convulsions . In addition, when a large overdose may occur liver   and acute renal failure .

In severe cases, ( hypotension , Seizures, difficulty breathing, renal failure , Irritation of the digestive tract), symptomatic therapy.

Activated carbon may be used. If there is a potential threat to life, you can spend a gastric lavage or induce vomiting.

Cooperation

For a single use capsule can lead to increased levels of lithium and digoxin in the blood plasma. Furthermore, they inhibit the action of diuretics . A by reaction with potassium-sparing diuretics   may cause hyperkalemia So that the patient must be carefully controlled.

The combination of the drug with other NSAIDs   and GCS   It increases the likelihood of undesirable side reactions. When used with anticoagulants   it is recommended to monitor the performance of blood clotting.

At the maximum dosage possible obstruction platelet aggregation .

Furthermore, the drug can not be used earlier than the day before or after administration Methotrexate Since it may enhance the toxicity and its concentration in the blood. Olfen 100 also increases cyclosporine nephrotoxicity . The interval of several hours and must be observed when receiving Colestipol   or Cholestyramine . The first means reduces the extent of absorption diclofenac   approximately 30%, while the second - 60%.

Terms of sale

The drug is sold only by prescription.

Storage conditions

The temperature should be 25 ° C. Keep the tool should be in a dry place.

Shelf life

Keep the medication should be no longer than five years from the date of issue, after which time taking capsules prohibited.

Reviews

Opinions of patients about this vehicle mostly positive. They note the convenient form of release and efficacy of the drug. Among the shortcomings referred only to the possibility of adverse reactions.

Price, where to buy

The drug is sold in Ukraine. You can buy it, on average, 75 hryvnia.

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