Nystatin

Description overdue on 11.02.2012

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Antifungal agent . It is a polyene antibiotic, is highly active against Candida yeasts. In the structure of nystatin contains double bonds that have a high affinity for sterol component of fungal cell membranes, it contributes to the process of embedding nystatin molecule in the cell membrane, followed by the formation of a huge number of channels through which the electrolyte is an uncontrolled transportation. With increasing osmolarity cell dies. Drug resistance is developing quite slowly. Nystatin is available in tablet form, in the form of suppositories (rectal, vaginal), granules, ointments.

Indications:

Nystatin appointed to defeat yeast-like fungi   digestive tract, kidney, lung, vagina, mouth, skin. The drug is used to prevent candidiasis   after prolonged antibiotic therapy neomycin, chloramphenicol, tetracycline.

Contraindications:

Nystatin is not prescribed for diseases of the digestive tract: pancreatitis , Liver disease, ulcerative lesions. The drug is contraindicated in pregnancy.

Side effect:

Nystatin can provoke allergic reactions. At reception tablet form   drug marked dyspepsia, bitter taste in the mouth, stool disorders, nausea. Application suppository   It can irritate the vaginal walls. Nystatin Ointment   rarely causes a burning sensation, irritation of the skin. Upon detection of drug-resistant forms of the fungus treatment with Nystatin is stopped.

Mode of application:

Nystatin pills take up to 4 times a day, 500 thousand units. At night no more than 6 million units. The duration of treatment up to two weeks. If necessary, permissible conduct repeated course. Nystatin is used topically twice a day for 250-500 thousand units (vaginally or rectally). Nystatin ointment applied to the skin twice a day in a thin layer. When applying the ointment simultaneously receive nystatin tablets.

Special instructions:

Treating fungal infections of the vagina involves simultaneous antifungal therapy all possible sexual partners. During menstruation antifungal treatment is stopped. Nystatin prescribed during pregnancy only in situations where the need for the drug is much higher than the possible risks and negative effects on the fetus. When concomitant administration with clotrimazole   marked decline in the efficiency of the latter.