Normase

Description overdue on 07/22/2014

• Latin name: Normase
• ATC code: A06AD11
• Active substance: Lactulose (Lactulose)
• Manufacturer: L. Molteni & C. dei FrateIli Alitti Societa di Esercizio (Italy)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Normase (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Synonyms
• Analogs
• Newborns
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The syrup composition comprises lactulose   (active substance) as well as flavoring, citric acid (additive materials).

Product form

The syrup is a liquid syrupy consistency, it is transparent and has a light yellow color, a distinctive sweet flavor. Contained in bottles of dark glass of 200 ml, in a cardboard box contains a measuring cup made of polyethylene.

Pharmacological action

Normase affects the body as a laxative Providing an osmotic laxative and gipoammoniemichesky effect. Lactulose is a synthetic oligosaccharide, which indicated the presence of residues of galactose and fructose.

Enzymes which are capable of lactulose cleaved in the human body is not. Therefore this substance remains unchanged under the influence of acidic and alkaline media, hence in the colon, it is unchanged.

Once in the colon lactulose is exposed to specific microflora, then the process hydrolyzing   followed by the formation of organic acids. Main metabolite of lactulose   - A lactic acid and its metabolites are formic and acetic acid.

Under the influence of lactulose level increases the osmotic pressure in the colon, which promotes the ingress of fluid into the large intestine from the blood. This in turn determines the increase in the volume of stool, their significant softening. Given the increasing volume of stool is stimulation of intestinal peristalsis.

When injected into the colon lactulose it creates an acidic environment, suspend the development and growth of pathogenic organisms. It is in the acidic environment of the most active breed lacto - and bifidobacteria. Therefore, under the influence of lactulose recovering microflora and maintained its normal balance. This contributes to the maximum full absorption of nutrients, in particular, calcium salts, phosphates, normalization of exchange processes, protein, enhancing synthesis of a number of vitamins, which produces intestinal microflora.

Also lactulose increases the secretion of bile into the intestine, passage of blood activates ammonia in the intestinal lumen and its ionization. Under the influence of lactulose content decreases toxins in the blood, in particular ammonia. At the same time the liver is working with less intensity, which has a positive effect on the condition of people with impaired liver function.

Pharmacodynamics and pharmacokinetics

The drug increases the level of acidity in the large intestine and stimulates intestinal motility, softening the stool. Laxative effects is no effect on smooth muscle and intestinal mucosa.

Action means occurs 24-48 hours after oral administration, as initially the drug passes through the digestive tract is fully human.

It noted the low level of absorption of lactulose metabolites in blood, about 8% of the metabolites excreted in urine. Basically, the drug is excreted in the feces.

Normase inhibits growth Salmonella in the colon. Addiction to the drug is not indicated, the absorption of vitamins does not reduce it.

Indications

Normase indicated for the treatment of the following conditions:

• Chronic constipation : Used for infants, the elderly, pregnant women.
• Hepatic encephalopathy : Used for the purpose of therapy and prevention of a coma and precoma in patients with hepatic encephalopathy.
• Violations of the microflora in the colon : Among other things, used for detection of Salmonella.
• Dysbacteriosis After treatment with antibiotics, for violations in the diet.
• It is used before and after surgery with the purpose of the regulation of stool in patients hemorrhoids .
• Syndrome putrid dyspepsia : Including manifested as a result of food poisoning, is used to treat young children.
• Ammoniemia .

Also, the drug is used in complex treatment of vaginal candidiasis , Vaginal dysbacteriosis, osteoporosis .

Contraindications

Normase treatment is not practiced in the following cases:

• High-sensitivity agent ingredients;
• intolerance galactose, fructose;
• bleeding in the gut;
• galactosemia ;
• bowel obstruction;
• is suspected appendicitis ;
• appendicism .

Precautions Normase used to treat patients with diabetes .

Side effects

Perhaps the manifestation of the following side effects:

• nausea, diarrhea, flatulence ;
• disruption of water and electrolyte metabolism (with prolonged therapy);
• dizziness, headache;
• myalgia, arrhythmia ;
• weakness, fatigue.

Instructions for use Normase (method and dosage)

If the patient is assigned Normase, instructions for use should be carefully observed. The syrup should be drunk after a meal.

Instructions for use Normase constipation stipulates that adult patients take the first three days of treatment of 15-40 ml daily, in the following days, the dose is 10-25 ml per day.

6 years after the Children and adolescents receive the first three days daily with 15 ml, more drug is given in a dose of 10 ml a day.

Children aged 1-6 years should take 5-10 ml per day. Children under 1 year are taking Normase 5 ml per day.

Depending on the person's general health and the course of his disease treatment can last from 1 to 4 months.

Patients diagnosed with hepatic coma, prekoma, encephalopathy, or have elevated blood ammonia levels, Normase administered at a dose of 30-60 ml three times per day. Further dosage is determined so that the person observed soft stool 2-3 times a day. The process of treatment lasts at least three months.

After the surgery Normase be taken 18 hours after which the treatment lasts 3-5 days. Adults take 10-30 ml per day Normase three children after 1 year - 5-10 ml 2-3 times a day. Children under 1 year old should take 5ml Normase 2-3 times a day.

Overdose

There were no cases of overdose Normase.

Cooperation

Together with the admission antibiotics   and antacids Normase efficiency decreases. Under the influence of lactulose modified release preparations in which the marked dependence on pH.

Normase desirable to take no earlier than two hours after the consumption of any drug.

Terms of sale

Normase dispensed in pharmacies without a prescription.

Storage conditions

Store means you need a temperature of 15 to 25 ° C. It can not freeze. Normase should be protected from children.

Shelf life

Store can be 3 years.

Cautions

If the treatment is carried out for a long period exceeding six months is necessary to regularly determine the level of chlorine, potassium, carbon dioxide in the blood.

Patients gastrocardiac syndrome should increase the dose gradually to prevent the manifestation of flatulence.

Synonyms

Lactulose . Lactusan . Portalak . Dufalac . Laktuvit .

Analogs

Match code ATC 4th level:

• Dufalac
• Forlaks
• Fortrans

In pharmacies, you can buy the following analogues of the drug Normase: Good luck . Dufalac . Romfalak . Lactusan . Laktuvit . Normolakt   and others. All analogues have on the body the same effect, but the final decision on the appointment of certain funds should only be attending specialist.

Is it better or Dufalac Normase?

Very often, parents have doubts about which drug is better to choose for the treatment of a child - or Normase Dufalac. Much difference between these funds is not, as both drugs are based on the same active ingredient - lactulose. Therefore, the body of the child and an adult they act the same way.

Newborns

Normase Infant applies if they have constipation associated with different diseases or characteristics of the organism. In the application of funds for the parents of newborn reviews it indicates that Normase effectively eliminates constipation associated with the peculiarities of the power feeding mother and baby, the problems in the process of introduction of complementary foods transferred to artificial feeding and others.

Normase - natural bifidogenic agent, so it can be used without restriction for newborns. Treatment should begin with minimal doses, while observing the condition of the baby. Normase does not cause addiction, has a pleasant taste and smell.

Normase during pregnancy and lactation

Normase can be used during pregnancy because it has no negative effects on the fetus. In the bloodstream lactulose misses, so systemic effects on the body has not. Reviews in pregnancy mostly positive, as the drug helps effectively eliminate constipation is a common problem for women expecting a baby.

In addition, Normase has a positive impact on the microflora of the vagina, preventing ascending infection. Breastfeeding Normase well appointed.

Reviews Normase

Reviews Normase network mostly positive, it is often used as a treatment for adults and children, particularly infants. Those parents who have used the drug for children, opinions about Normase often write and that the drug is well tolerated, does not cause negative effects and even allows you to get rid of chronic constipation. It is noted that the means should be used exactly as prescribed by your doctor.

Also, those who used the drug for treatment of children and infants, reviews written, and that the drug was delicious and well perceived by children. Mostly positive experience of treatment and remained Normase in pregnant women who use it to get rid of constipation.

Price Normase where to buy

Normase cost is about 200-260 rubles. 1 bottle.

Price Normase in Ukraine - from 55 to 80 hryvnia.

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