Baklosan

Description overdue on 06/24/2014

• Latin name: Baclosan
• ATC code: M03BX01
• Active substance: Baclofen (Baclofen)
• Manufacturer: Pharmaceutical Works POLPHARMA, S.A. (Poland)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Baklosana (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One tablet contains 25 mg or 10 mg baclofen   as the active substance.

Excipients: lactose   gelatin, potato starch, magnesium stearate talc ethylcellulose.

Product form

Baklosan is a biconcave, round, with a dividing strip of white pills. 50 of such tablets in a polypropylene jar, one such bank in the paper bundle.

Pharmacological action

Myorelaxation   and antispastic   effects characteristic of the drug.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Baklosan refers to muscle relaxants   Central action; inhibitor GABAB-receptor . Reduces anxiety distal parts bearing nerve impulses sensitive fibers and inhibits the intermediate cells of the nervous system. The result is inhibition of synaptic transmission pulses; voltage drop of the muscle fibers. The drug has no effect on the transmission of nerve impulses in the muscle-nerve synapses.

In diseases characterized by pathological constant contractility of skeletal muscle, the drug Baklosan eases cramps and painful spasms. The drug increases the range of motion in the joints simplifies kinesotherapy   (massage, gymnastics, manual therapy).

Pharmacokinetics

After receiving tablets Baklosana adsorbed in the intestine of a high degree. The maximum blood concentration is observed after three hours after treatment.

Binding to plasma proteins is 30%. The drug crosses the placental barrier, excreted in breast milk. Metabolism occurs in the liver. Excreted in the urine in its original form.

Indications

The drug is used in conjunction with an increase in muscle tone when:

• spinal cord pathology (tumors, trauma,   syringomyelia , Motor neuron disease);
• multiple sclerosis ;
• cerebral palsy ;
• cerebrovascular diseases;
• meningitis ;
• head injuries.

Contraindications

Contraindications to the use Baklosana are:

• Parkinson's disease ;
• psychoses ;
• cramps (including the last);
• epilepsy ;
• intolerance lactose , Failure Lactase . malabsorption ;
• stomach ulcers and 12 duodenal ulcer;
• pregnancy ;
• lactation;
• allergy   to the drug.

Baklosan with caution used in insufficient blood supply to the brain, atherosclerosis   cerebral blood vessels, renal failure , The elderly and children under three years.

Side effects

• From the musculoskeletal system: myalgia .
• From the nervous system: weakness, dizziness, gait disturbance, insomnia , Sedation, depression . euphoria . asthenia . tremor , Hallucinations, nightmares, nystagmus . paresthesia . ataxophemia .
• From the respiratory system: respiratory depression.
• Since the cardiovascular system: reduction cardiac output . hypotension .
• For part of the vision: visual impairment.
• From the digestive system: diarrhea . constipation . dyspepsia , Nausea, abdominal pain, liver damage.
• With the genitourinary system: enuresis . polyuria , Urinary retention, sometimes - erectile dysfunction .
• Skin: hyperhidrosis .
• General disorders: decrease in temperature.

In extremely rare cases, it revealed an increase in spasms, which was evaluated as the paradoxical effect of the drug.

Instructions for use Baklosana (method and dosage)

Instructions for use Baklosana to take medication orally with food. If an error was missed one dose, the next time you should not use a double dose.

Adult

The starting dose of - 5 mg (half tablets 10 mg) three times a day, with increasing doses of 5 mg every three days, and so on until the onset of therapeutic effect (usually suffice 30-75 mg per day). The maximum daily dose - 100 mg.

Final dose should not lower the tone of the muscles leads to the expression myasthenia   or impair motor function.

In renal failure, or at the time of Hemodialysis   daily dose - 5 mg.

In persons older than 65 years the dose should be increased with caution, because they have a high risk of side effects.

Children

The starting dose of - 5 mg three times a day. If necessary dose can be increased every three days by 5 mg until the therapeutic effect.

Recommended dosage: for children aged 3-6 years - 20-30 mg / day; 6-10 years - 30-60 mg / day; older than 10 years, limiting daily dose - 2.5 mg / kg, the starting dose - 1.5-2 mg / kg.

Abolition of the drug to slowly (within 10-14 days).

Overdose Baklosanom

Overdose symptoms: respiratory depression, muscle hypotension . coma . confusion .

Treatment: abundant fluid intake, use of diuretics Under the oppression of respiratory function - ventilation . Antidote is unknown.

Cooperation

In a joint application Baklosan activates the effect of drugs that affect the nervous system, reducing pressure, antipodagricheskih   means alcohol.

At simultaneous reception with Baklosana tricyclic antidepressants   develops pronounced decrease in muscle tone.

Do not take with Baklosan carbidopa   and levodopa As may appear confusion and hallucinations.

Terms of sale

The drug can be purchased strictly on prescription.

Storage conditions

Keep away from children. Store in a dry, dark place at a temperature not exceeding 25 degrees.

Shelf life

Three years.

Cautions

Side effects Baklosana are often temporary, they need to differentiate between the symptoms of the underlying disease.

In individuals with   diabetes   and diseases of the liver is recommended to regularly monitor the level of transaminase, alkaline phosphatase   and Glucose   in blood.
Patients undergoing therapy Baklosanom should refrain from activities associated with attention and reaction.

Analogs Baklosana

Match code ATC 4th level:

• Tizalud
• Sirdalud
• Baclofen

Liorezal   and Baclofen   - The main counterparts Baklosana.

Babies

Children under 12 years prescribed with caution.

With alcohol

Baklosan greatly enhances the negative effects of alcohol, so the period of treatment should refrain from taking alcoholic beverages.

During pregnancy and lactation

Baklosan contraindicated during pregnancy and lactation.

Reviews Baklosane

Recommendations and reviews of Baklosane show - the majority of patients were satisfied with the results of the drug. It is rare to read the negative reviews about tablets Baklosan associated with the occurrence of side effects.

A number of patients drug treatment clinics often use the drug in combination with certain drugs. Baklosan in this case, can cause trip or "arrival." It is known that such a use of the drug development turns into addiction.

As a "get down" with formulation Baklosan?

This frequently asked question by patients. If the syndrome is the result of the drug at the recommended doses, then stopping should produce progressively within two weeks. If the relationship has arisen as a result of unauthorized use of the drug to achieve the effect of drugs, you should seek help from a narcologist.

Price Baklosana

Price Baklosana 10 mg in Russia - 213-256 rubles, to buy 50 tablets of 25 mg will cost - 405-498 rubles. In Ukraine, the average price Baklosan tablets 10 mg - 59 hryvnia, 25 mg - 104 hryvnia.

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