Description overdue on 11/30/2014
- Latin name: Fungoterbine
- ATC code: D01AE15
- Active substance: Terbinafine (Terbinafine)
- Manufacturer: Of Valium, Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
As a part of tablets is 250 mg of active substance terbinafine and mounting parts (Kollidon 30, benzoic acid, microcrystalline cellulose, Kollidon CL-M, aerosil, magnesium stearate).
Cream (cream) for topical use contains 1 gram of the active ingredient - terbinafine hydrochloride 100 grams agent. Also in the drug contains: urea, cetostearyl alcohol, imidomochevina, liquid paraffin, water, butylated hydroxytoluene, tsetostearat macrogol, poloxamer, propylene glycol, vaseline.
Spray (1 g) contains 10 mg terbinafine hydrochloride, urea, ethanol, propylene glycol, BHT, povidone.
Product form
- The drug is released in the form of flat white tablets And round, with a mark in the middle. In a cardboard blister pack of 1, 10 tablets.
- Cream Fungoterbin It has a smooth consistency and a light odor. Color - white or nearly white, opaque. Ointment is sold in tubes of 15 grams.
- Spray - A clear, colorless liquid, odorless and tasteless. Available in bottles of 15 or 30 ml.
Pharmacological action
Antifungal, fungicidal .
Pharmacodynamics and pharmacokinetics
The active ingredient is a broad-spectrum antifungal. Terbinafine stops synthesis ergosterol (inhibits enzyme squalene epoxidase ), Thus breaking biosynthetic processes in the cells of fungi. The drug is active against the dimorphic fungi, dermatophytes and various mold .
The drug has no effect on hormones Or metabolism other medications. Part of the funds urea contributes to a better penetration of agents into cells, accelerates tissue repair in the areas affected by fungus.
After receiving tablets for 2 hours achieved max. concentration in blood plasma. About 90% of the substance binds to proteins in the plasma.
The substance tends to accumulate in the sebaceous glands, hair follicles , Hair, after 7-14 days of regular use - in the nail plate and stratum corneum .
The half-life of 16-19 hours, withdrawal of the drug through the kidneys (it inactive metabolites ) And horny layer of the skin. For people with liver or kidney disease possible extension of the period of removal from the body.
When using the cream and spray into the blood plasma gets about 5% of active ingredient that does not reflect on the processes occurring in the body.
Indications
Tablets are used:
- treatment fungal infections skin caused by Trichophyton spp. (Trichophyton rubrum, Trichophyton verrucosum, Microsporum canis, Trichophyton mentagrophytes, Trichophyton violaceum, Epidermophyton floccosum) ;
- at candidiasis ;
- treatment depriving multicolored ;
- at athlete's foot ;
- at defeat dermatophytes smooth skin or inguinal regions.
Fungoterbin Ointment is indicated for the topical treatment in the complex therapy of the above diseases.
The spray is usually used to treat seborrhea That emerged in the hairy part of the head.
Contraindications
The tool does not prescribe:
- Children up to 12 years;
- at allergies into its components;
- pregnant and nursing women.
Tablet form can not be applied to persons with kidney disease and liver , from lactase deficiency .
Care should be taken:
- at tumors various kinds;
- at lupus erythematosus ;
- alcoholics ;
- If you have problems with hematopoiesis;
- in pathological processes in the vessels;
- metabolic disorders.
Side effects
When using the cream and spray reactions may occur hypersensitivity skin, itch , Burning sensation, rash, up to hives and angioedema . Should distinguish between different kinds of adverse reactions.
Also, when taking the tablets were observed:
- arthralgia or agranulocytosis ;
- pain epigastric area;
- indigestion ;
- lymphopenia ;
- anorexia ;
- distortion of taste;
- thrombocytopenia ;
- neutropenia ;
- myalgia ;
- Stevens-Johnson syndrome .
Instructions for use (method and dosage)
Depending on severity of the disease and its recommended dosage and a different dosage form of the drug.
Instructions on Fungoterbin tablets
The tablets are taken orally, preferably after a meal.
Adults appoint 250 mg a day means once.
With mycosis on the skin of the recommended course of treatment - from 2 to 6 weeks. When mycosis scalp treatment - one month.
With onihomikozah duration of administration of the tablets is from 6 to 12 weeks, depending on the localization of the fungus.
The improvements in the appearance of the skin or nails come in a couple of weeks or even months after treatment.
For children from 2 years of daily dosage is calculated from the ratio of 0, 32 mg per kg body weight. Accordingly, if the child weighs 20 kg, the daily dosage - a quarter of a tablet to 40 - half, more than 40 - the whole tablet.
The recommended dosage for patients with renal failure and liver disease - 125 mg per day.
Cream Fungoterbin, instructions for use
The ointment is applied only topically. Before use, the affected area should be cleaned and dry.
The cream is applied 1-2 times a day, depending on the disease and on the affected area a little rubbing. Sometimes it is necessary to impose a gauze bandage.
With tinea leather, legs, wrinkling of the skin and stop the drug is applied 1 time per day during the week.
With candidiasis Skin - 2 times a day for 7 days.
With ra znotsvetnom zoster duration of treatment is a week, the multiplicity of applications - one or two times per day.
Guide to Spray
It is used topically. Means also applied to previously cleaned and dried portions. After applying the skin should be evenly moist. Also recommended to treat the lesions and the surrounding skin.
Multiplicity of reception is the same as for the cream.
Overdose
With an overdose of pills could increase side effects and cause dyspepsia . Treatment depends on the manifested adverse reactions.
If you get into the cream, you should wash the stomach and produce a symptomatic therapy.
Cooperation
Tablets should be combined with caution rifampicin, an H2 receptor antagonist of histamine, terfenadine, oral kontatseptivami, caffeine, hepatotoxic agents, inducers of microsomal oxidation and Drug Administration, which is involved in the metabolism system P450 .
Terms of sale
To purchase a tablet may require a prescription.
For the purchase of cream and spray a prescription is not needed.
Storage conditions
At a temperature not exceeding 20 degrees.
Shelf life
2 years.
Cautions
Improvements need to be able to occur no later than 2 weeks after initiation of treatment. This usually occurs within the first days of use of the drug. If not, you need to specify the diagnosis.
Correction dose for elderly patients is not required.
Avoid getting the cream and spray in the eyes and mucous membranes in the digestive tract.
Analogs
Mikoseptin
Termikon
Soultz
Nitrofungin
Baziron AU
Lamitel
Exoderil
Naftin
Loceryl
Batrafen
Terbizil
Lamisil
The closest analogues: Fungoterbin Neo Binafin, Lamisil, Lamifast, Terbizil, Lamikon, Mikofin, Ekzifin, Atifin, Terbiks, Terbifin .
During pregnancy and lactation
The drug at pregnancy possible after consultation with a specialist. The studies did not reveal teratogenic properties of the drug. When the pill breast-feeding should be discontinued, since the drug is excreted in breast milk.
Reviews Fungoterbine
Reviews Fungoterbine good. The cream quickly and efficiently eliminates the fungus, especially in the legs. It has a convenient form of release, is relatively inexpensive. Some prescribe pills. At their reception adverse reactions are rare, the drug effectively in comparison with analogues. In addition to reviews of the ointment Fungoterbin, many write about the experience of the application of a spray for the treatment of fungal diseases in the head. The drug is very good in the first days of illness.
Price Fungoterbina
Cost tablets Fungoterbin It is 274 rubles for 10 tablets.
How much does the ointment? Cost cream Fungoterbin 1% (15 g) - 250 rubles.
Price spray - About 247 rubles per 30 ml.
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