Ribomunil

Description overdue on 05/28/2014

• Latin name: Ribomunyl
• ATC code: LO3AX
• Active substance: Ribosomal-proteoglycan complex with typical bacterial antigens
• Manufacturer: Pierre Fabre Medicament Production (France)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Ribomunil (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The composition of the drug may vary slightly depending on the form of Ribomunyl:

• AT pills In addition to the main active substances include silicon   (0.5 or 1.5 mg) magnesium stearate   (2 or 6 mg) sorbitol   (up to 294 mg or 98.4 mg). The number of additional components depends on the mass initially titrated ribosomes   - In the first case the active component - 0.75 mg, and in the second - 0.25 mg. Also added to the drug proteoglycans cell wall   in an amount of 1.125 mg or 0.375 mg.
• The basis granules   is a mixture of active components is the same as with the number of tablets bacterial ribosomes   - 0.75 mg. Ie there is a part of: carbohydrate-protein membrane components   (1.125 mg) magnesium stearate   (2 mg) silicon   (0.5 mg) and sorbitol   (98.4 mg). However, to further enhance the effect and pharmacodynamics were added: D-mannitol 500 mg polyvidone   to 10 mg.

Product form

The product comes in two common forms:

• Round, biconvex pills   milky odorless and tasteless. The blister 4 or 12 units, depending upon the amount of biologically active ingredient.
• Whitish granules   Food odorless drinking solution as crumbly powder. At 500 grams in a bag, of which 4 pieces in a box, that is all - 2000 grams of the drug.

Pharmacological action

The complex of ribosome   and membrane proteoglycans   - Are components of pathogens of the upper respiratory tract, which contains copious amounts of antigenic structure identical bacterial. These components stimulate the production of specific antibodies, ie, possess immunomodulatory properties by activating the body's defense against a system of common strains aureus . Streptococcus . klebsiely   and others.

Membrane protein-carbohydrate elements can influence and non-specific immune response, which manifests itself as:

• Intensive macrophage   and leukocyte phagocytosis .
• Increased activity of the body's resistance factors (the synthesis of serum and secretory immunoglobulins . Interleukin-1   and Gamma-interferon ).

By producing biologically active mediators Ribomunil unspecific immune response can be used not only for treatment but also for prevention lesions of the upper respiratory tract .

Pharmacodynamics and pharmacokinetics

Experimentally trace the route of the components of the drug is not given possible, but there are theoretical concepts, according to which ribosomal-proteoglycan complex   lysed by immune cells in the body at the time of activation. Otherwise, after absorption, biologically active substances into the systemic circulation, where they interact with a nonspecific protection factors.

Indications

Ribomunil recommended for the prevention of indolent, recurrent infectious lesions   with possible serious complications. Very often it is used in pediatric practice, starting with 6 months of drug required to include in the course of medical treatment of ENT diseases as rhinitis . otitis . sore throat . sinusitis . laryngitis . pharyngitis .

It is also recommended to be used for the prevention Ribomunil infectious invasion of the respiratory tract   people in the relevant risk groups:

• sickly;
• with chronic pathology;
• in the presence of asthma ;
• if the work is associated with occupational hazards (miners, construction workers, and so on).

Contraindications

First of all, the therapeutic course with this drug should be available when intolerance or hypersensitivity to the constituent chemical components of the drug.

Do not use if Ribomunil autoimmune pathologies As it will cause degradation.

Use of the drug in periarteritis nodosa   and HIV infection   only under constant medical control (during inpatient treatment in a special compartment).

Side effects

As a rule, Ribomunil well tolerated in all age groups. However, early treatment can be observed transient undesirable effects, such as:

• Hyperptyalism   - Increased salivation.
• Dyspeptic symptoms - nausea . vomiting . diarrhea , abdominal pain.
• Systemic allergic reaction to the components of the drug - angioedema . hives , Generalized itching.
• The sharp rise in temperature to 39 degrees Celsius.

Instructions on Ribomunil (method and dosage)

It uses the drug orally on an empty stomach, preferably in the morning. Single dose depends on pharmacological forms:

• 1 tablet at a dose of 0.75 mg of the active ingredient.
• 3 tablets if the basic substance of 0.25 mg.
• The contents of one sachet dissolved in boiling water, if the original form of the drug - pellets.

Driving therapeutic course: initially the drug is used the first four days a week for three weeks. Further, to maintain a constant concentration of the components - for the next five months - the first four days of every month. Thus, we achieve sustained strengthening of the immune system.

Instructions for use Ribomunyl for children under 2 years has its own characteristics. So the therapeutic course of prevention can be divided into two periods of three months, if there are difficulties with the introduction of the drug in the body of the child. You also need to watch the baby for a while, because the drug can cause breathing problems in the organic immaturity of the respiratory tract.

Overdose

At the moment, there are no reliable clinical evidence that the pharmacological agents can cause an overdose.

Cooperation

In the pharmaceutical field is not described cases of adverse drug interactions with ribomunil. So it safely administered with antibiotics . bronchodilators   and antiinflammatories.

Terms of sale

Ribomunil released in the pharmacy without a special prescription form, as it has severe side effects and contraindications with possible fatal outcome.

Storage conditions

The drug should be stored in a dry place out of reach for young children, at a temperature of 15-25 degrees Celsius.

Shelf life

Subject to the conditions of storage, the drug retains its activity for 3 years.

Analogs Ribomunyl

Group immunomodulators   bacterial origin is not numerous, but on pharmacy shelves can be found medicinal product similar ribomunil - it Broncho-munal . A positive feature is the analogue of a smaller number of possible side effects and a shorter course of conservative prevention, but its price is slightly higher.

When pregnancy

Special clinical studies Ribomunyl action on the mother and child during periods pregnancy   and Lactation   not carried out, because the drug can be used only under the supervision of qualified medical personnel.

Reviews ribomunil

Doctors about ribomunil confirm all the positive aspects of its use in diseases of the upper respiratory tract. Clinical experience shows that even under low-intensity, prevention of recurrent infections proteglikanovyh-ribosomal complex   It reduces the rate of bacterial origin Conservative treatment and promotes rapid healing.

Dr. Komarovsky in their TV shows and on the official website suggests applying Ribomunil and its analogs in pediatric practice. " Do not wait for the disease, it is much better to avoid its occurrence using the effective prevention of immunomodulators "- This is what he says about it.

Reviews on Ribomunil for children: the majority of parents in various forums advise to buy the drug only in proven pharmacy, as are cases of counterfeit drug, which may adversely affect the health of the child.

Price Ribomunyl

In Ukraine, the drug can be bought for 100-160 hryvnia, depending on the pharmacy. The most profitable to order the drug on the Internet. In Russia, the price of Ribomunyl for children is about 300 rubles (the lowest known cost - 260 rubles).

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