Dopegit

Description overdue on 02/04/2013

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Central alpha-2-agonists.   The active component acts methyldopa. The drug reduces the heart rate and the IOC to ensure hypotensive effects, reduced systemic vascular resistance. The central nervous system is formed metabolite of the drug - alpha metilnorepinefrin, under the influence of which is reduced vascular tone, braked Sympathetic impulses . The drug is moderately inhibits renin activity, causes orthostatic hypotension, reduces peripheral vascular resistance, reduces tissue concentrations of epinephrine, dopamine, serotonin. Dopegit no significant effect on renal blood flow and the IOC, but increases the plasma volume. Prolonged therapy leads to regression of hypertrophied left ventricle size, an increase in the myocardium Collagen .

First dose leads to short-term hypertension. During intense exercise reduces the severity the hypotensive effect of . The medicament promotes water retention and sodium ions in the body slows the sinus rhythm increases baroreceptor activity that leads to possible development of refractoriness after prolonged therapy (1-1, 5 months). For typical medicament syndrome "cancel" . Dopegit can cause sedation, the expression of which is reduced by 2-3 weeks after start of therapy. The maximum drop in blood pressure is recorded after 4-6 hours, the effect lasts for 1-2 days. Hypotensive effect increases gradually. For intravenous infusion of the drug drop in blood pressure is recorded after 2-3 hours, the peak observed after 3-5 hours and the effect lasts for 6-10 hours. The drug increases renal blood flow. Dopegit available in tablet dosage form, in solution form.

Indications:

Drug Usage dopegit appoint him for hypertension mild to moderate severity. Dopegit permissible use of the drug during pregnancy.

Contraindications:

Dopegit does not apply to acute hepatitis , Methyldopa intolerance, acute myocardial infarction, systemic connective tissue diseases, severe liver disease and renal systems, breast feeding, pheochromocytoma Depression, cerebrovascular , Parkinson's disease, with hemolytic anemia , Simultaneous treatment with levodopa and MAO inhibitors, in patients with severe coronary atherosclerosis . When diencephalic syndrome, acute left ventricular failure, hepatitis history of medication prescribed with caution.

Side effect:

Nervous system:   horeoatetoidnye spontaneous limb movements, parkinsonism, sedation, dizziness, staggering when walking, headaches, Bell's paralysis , Lethargy and sleepiness. Cardiovascular system: pericarditis , Flushing of the skin of the upper body, peripheral edema, bradycardia, orthostatic hypotension Myocarditis, a heart failure worsening. Digestive tract : Yellowness, colitis, hepatotoxicity, increased hepatic enzyme system, vomiting, glossalgia, pancreatitis, diarrhea, dry mouth, nausea. Bodies of blood:   thrombocytopenia, agranulocytosis , Hemolytic anemia, leukopenia. Musculoskeletal system:   development arthralgia, myalgia. Endocrine system: loss of libido, amenorrhea, reduced potency. Allergic reactions such as exanthema, Lyell syndrome, febrile syndrome, rash. Prolonged therapy can cause a positive test registration Coombs. The treatment may inflammation of the salivary glands, nasal congestion.

Overdose:

Manifested intestinal, block, drop in blood pressure, vomiting, flatulence, bradycardia, tremor of limbs, diarrhea, drowsiness. It requires extra holding forced diuresis , Gastric lavage, the appointment of agonists.

Mode of application:

Dopegit the first 2 days appoint 250 mg in the evening, then a single dose every 2 days and increased by 250 mg to achieve the desired torque and optimal antihypertensive effect (stendartnaya scheme - 1 gram of methyldopa 2-3 admission) .  Perhaps the increase in evening dose of medication to reduce the severity of sedation .  At the appointed day no more than 2 grams of the drug (in combination therapy with other antihypertensive drugs - methyldopa appoint not more than 500 mg / day) .  After achieving the desired stabilization and hypotensive effect of the amount of the drug is gradually reduced to the minimum effective dosage indicators .  Warn syndrome "cancel" can be a gradual decrease in the number of methyldopa .  Patients with severe renal pathology system is recommended to reduce the single dose .  Perhaps intravenous drip drug: 100 ml of 5% dextrose diluted with 250-500 mg of active substance, the resulting solution is administered over 30-60 minutes .

Special instructions:

During pregnancy dopegit appoint strict conditions. Methyldopa treatment requires regular monitoring of liver function parameters of the work, the state of the peripheral blood. Dopegit able to mask hyperthermia in diseases of infectious nature. The drug affects the result of the determination of serum creatinine, Uric acid and others. When storing the urine of patients taking dopegit acquires a darker shade. The drug registration is canceled if a positive Coombs' test, the diagnosis of hemolytic anemia. Peripheral blood can independently normalized during the treatment, in some cases the appointment of glucocorticosteroids . Unacceptable use of alcoholic beverages. Dopegit able to have a negative impact on the management of vehicles, concentration.

Drug Interactions:

Increased severity of side effects observed during concurrent therapy MAO inhibitors   (agitation, severe hypertension or hypotension). When treating tricyclic antidepressants   marked headache, agitation, tachycardia , Reducing the severity of the hypotensive effect. Combination with levodopa causes increased antiparkinsonian action is explained lockup levodopa decarboxylation process at the periphery under the action of methyldopa and increased levels of levodopa in the central nervous system. But the predominance of inhibitory processes in the decarboxylation of the central nervous system, there is a decrease of severity antiparkinsonian effects of levodopa.

Orthostatic hypotension   observed during simultaneous treatment with medicines, which include Carbidopa and Levodopa (recommended for 2 hours after taking the drug in a horizontal position). The risk of developing sick sinus syndrome   increases when the joint treatment of elderly patients with digoxin; developing dementia with haloperidol. Combination therapy with beta-blockers cause orthostatic hypotension, possibly raising blood pressure. Increased hypotensive effect observed in the appointment of nifedipine, diuretics and medications hydralazine . Simultaneous treatment with indomethacin, adrenostimulyatorov, preparations of NSAIDs leads to a decrease of expression of hypotensive effect.

Tranquilizers (anxiolytics) can enhance the hypotensive effect. When the acidification of urine in patients receiving methyldopa its effect is reduced when alkalization - amplified. Patients who receive methyldopa during general anesthesia may develop kollaptoidnye state So preparation cancel 7-10 days prior to surgery. Dopegit administered with caution to patients who receive thiopental sodium, ftorotan   Other medikmenty for general anesthesia. Ethyl   contraindicated. The drug is incompatible with diakarbom , Procainamide, quinidine , Antipsychotics. Dopegit potentiate hepatotoxity   oral contraceptives; increase the toxicity of lithium salts.