Midecamycin

Description overdue on 14.12.2011

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Antibacterial drugs, macrolide . Large dosages of the drug has a bactericidal effect on microorganisms, low doses - bacteriostatic. The principle of operation is based on drug inhibition of protein synthesis in the bacterial cell. When receiving oral forms midecamycin rapidly and almost polnotsyu pischevraitelnogo absorbed from the tract. In the internal organs (submandibular gland, parotid gland, bronchial secretions, tonsils, lungs) and skin drug concentration is higher than serum . Midecamycin metabolized in the liver system, forming two active metabolite. Metabolic products are derived largely from the bile, less than 10% is excreted in the urine. Produced in tablet form or in powder form for preparation of suspensions.

Indications:

Midecamycin prescribed for infectious diseases in the inability to use penicillin antibiotics: oral infections, infections of the respiratory tract, NGU   and other infections of the genitourinary system, infections of the soft tissues of the skin. The drug effectively used for the treatment of pertussis . Diphtheria . otitis , Erysipelas, pneumonia, tonsillitis . scarlet fever . sinusitis . enteritis   ( Compylobacter ) brucellosis, trachoma, Legionnaires' disease .

Contraindications:

Midecamycin not indicated in severe renal disease, hepatic systems. With care prescribe allergy history.

Side effect:

The drug may be accompanied by a feeling of heaviness in the epigastric dyspeptic disorders, allergies, anorexia, elevated levels of bilirubin, liver enzymes.

Mode of application:

Before using the product it is recommended to test the sensitivity of microflora to antibiotics midecamycin. Vzsrolym designate 0, 4 grams of the drug three times a day, the average daily dose is 1, 2 grams, the maximum daily dosage - 1, 6 grams. Children with severe infections and moderate flow appoint 30-50 mg / kg, with a mild form - 20 mg / kg, three times a day. Younger children midecamycin administered as a suspension: the content of one vial was diluted to 100 ml with distilled water, mixed well and shaken. A single dose of the drug according to weight: up to 5 kg - 2, 5ml suspension, 5-10 kg body weight - 5ml, with a weight of 10-15 kg - 7, 5 ml, 15-20 kg - 10 ml of the suspension, 20-30 kg - 15 ml. A suspension suitable for use within 2 weeks when stored in the refrigerator. The course of treatment lasts for up to 10 days. If necessary, antibiotic therapy can be continued.

Special instructions:

Midecamycin used during pregnancy only in those situations where the therapeutic effect is much greater than the possible adverse effects of the drug on the fetus. The appointment of the drug during lactation doctor should raise the question of the possibility of termination of breast-feeding for a period of antibiotic therapy. Long-term treatment requires constant, careful monitoring of blood picture, liver enzyme levels of the system. Midecamycin should be stored in a dry place, protected from light exposure, away from children.

Drug Interactions:

Cycloserine   reduces the rate of excretion of drug metabolites midecamycin. Metabolism carbamazepine , Ergot alkaloids in the liver is significantly reduced when concomitantly with midecamycin. The drug reduces the rate of excretion of warfarin, anticoagulants .