Prednisolone

Description overdue on 17.12.2011

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The preparation prednisolone   - An analogue of the hormones cortisone   and hydrocortisone   synthetic type. These hormones in the body are distinguished by the adrenal cortex. The drug is active, is 4-5 times higher than that of cortisone in the 3- and 4-fold - the hydrocortisone. However, he does not cause sodium and water retention, and increased excretion of potassium slightly. Prednisolone acts as antiallergic . anti-inflammatory . protivoshokovoe . antiexudative . antitoxic   means. Thanks to the participation of cytosolic receptors glucocorticosteroids   anti-inflammatory effect is achieved. Also prednisolone slows down the synthesis of nucleic acids (primarily DNA) in dermal fibroblasts   and cells epidermis   (basal layer). Anti-allergic effect occurs due to the decrease in the number of basophils . Also, this means retards the synthesis and secretion of biologically active substances. The drug is well-absorbed from the gastrointestinal tract. After half an hour after drinking oral prednisolone in the blood reached its highest content. Because the body is excreted in the feces and urine. The drug wilts protection through the placenta and breast milk.

Indications and methods of use of the drug:

The drug prednisone is prescribed for kollagenozah . rheumatism , Infectious nonspecific polyarthritis type asthma . Myeloid . acute lymphoblastic leukemia , Infectious mononucleosis . neurodermatitis . eczema As well as in other diseases of the skin. The drug is effective against allergic diseases Addison's disease . glomerulonephritis , Acute adrenal insufficiency, acute pancreatitis, shock, collapse. This drug taken during surgery when homotransplantation organs and tissues to suppress rejection. Also, prednisolone is used in the treatment of various types of conjunctivitis, inflammation of the cornea, if not damaged mucosa, inflammation of the sclera and episclera, sympathetic inflammation eyeball. Also used with symptoms of irritation of the eyeballs after injuries and operations.

Dose the doctor sets individually. In acute conditions and for the opening appointed dose of 20-30 mg prednisolone per day. As a maintenance dose of 5-10 mg administered per day. In some cases, the expert can set a higher dose. Should stop taking slow, thus reducing the dose gradually. Patients with a history marked psychosis drug in high doses can be taken only under medical supervision.

In the case of shock prednisone administered intravenously by: 30-90 mg of the drug is slowly injected into a vein or taken drip. When intravenously administered drug for some reason difficult, then, as an option, it is introduced deep into the muscle. If there is evidence, re-injected drugs, the dose in this case is 30-60 mg. After an acute condition has been removed, the patient continues to receive the drug in the tablets.

Children appoint the next dose of the drug: children 2-12 months - 2-3 mg per 1 kg of body weight; children 1-14 years - 1-2 mg per 1 kg weight. Deposit of funds should be slowly intravenously. If necessary, re-introduced at the expiration of 20-30 minutes.

Prednisolone as a suspension or solution for injection is administered intra-articularly, intramuscularly, and the infiltration method. This requires very strict adherence to sterility. When administered intra-articularly injected drug dose of 10 mg in the small joints, 25 mg or 50 mg in large joints. This injection can be done repeatedly. Once there have been several injections must estimate how pronounced therapeutic effect. If the results are unsatisfactory treatment, it is recommended to increase the dose. The dosage of the introduction of infiltration is 25 mg or 50 mg, with the important value of the affected part of the body.

Eye slurry apply 1 to 2 drops three times a day in the conjunctival sac. This treatment should not last longer than two weeks.

At the use of the drug is necessary to constantly monitor blood pressure, blood sugar levels, to conduct research of urine and feces, administered antibiotics, anabolic hormones.

Contraindications and side effects:

Do not use prednisolone at hypertensive disease . diabetes   (severe) and Cushing's disease . It is impossible to prescribe a drug for pregnant women, patients with circulatory failure III stage acute endocarditis . jade , Psychosis, osteoporosis . ulcer . syphilis , Active form TB . Do not prescribe medication after surgeries, elderly people.

If you take the drug for a long time, as a possible side effects obesity . hirsutism , Acne, osteoporosis, disruption of the menstrual cycle, Cushing's syndrome, ulcers of the digestive tract, hemorrhagic pancreatitis, hyperglycemia , Low resistance to infections, high blood clotting, in violation of the mental state. If you suddenly stop the medication long-term therapy, may occur withdrawal, adrenal insufficiency and exacerbation of the disease, which is treated with prednisone.

Specific recommendations:

It is necessary to adjust the dose of the drug, subject to the simultaneous reception of antidiabetic or anticoagulant drugs. Store prednisolone should be according to the rules of the list B, in a dark place.