Sulfasalazine

Description overdue on 01/13/2013

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Anti-inflammatory, anti-microbial intestinal remedy.   The drug active is used in treatment of nonspecific colitis. Description of the mechanism of drug action Sulfasalazine: effects based on the principle of selective accumulation of the active substance in the connective tissue in the intestinal walls, as well as to the gradual release of 5-ASA ( aminosalicylic acid ) And sulfapyridine. Aminosalicylic acid has anti-inflammatory effect, but a component sulfapyridine   bacteriostatic and antimicrobial effects. Sulfasalazine is active against Neisseria gonorrhoeae, streptococci , Diplococci, and E. coli. The drug is available in tablet dosage form with an enteric coating.

Indications:

Instructions for use of the drug sulfasalazine recommends prescribers at ulcerative colitis .

Contraindications:

Sulfasalazine is not indicated in case of intolerance sulfonamides at porphyria , Anemia, chronic renal disease and liver, breast feeding, congenital deficiency of glucose-6-phosphate dehydrogenase. The medicine is not applied in the treatment of children under 5 years.

Side effect:

Responses to the drug sulfasalazine show such side effects as epigastric pain , Dizziness, headache, decreased appetite, vomiting, nausea, violation of a chair, photosensitization , Toxic epidermal necrolysis, blood in faeces, interstitial pneumonitis , Thrombocytopenia, leukopenia, agranulocytosis, staining of urine yellow-orange color, malignant exudative erythema, allergic response, drug-induced hepatitis.

Mode of application:

Sulfasalazine prescribed 4-6 times a day for 1 gram, a course of treatment is 2-3 weeks. Gradually reduce the dose every 5-7 days at 0, 5-1 grams. The maximum duration of therapy is 6 months. Children aged 5 to 7 years of drug administered 3-6 times a day for 0, 25-0, 5 grams. Children older than 7 years of prescribed medication 3-6 times a day for 0, 5 grams.

Special instructions:

Sulfasalazil drug prices can vary depending on the pharmacy network. Prolonged therapy sulfanilamide requires regular monitoring of the dynamics of the state of peripheral blood.

Drug Interactions:

Sulfasalazine increases the effects of antiepileptic drugs, anticoagulants , Oral hypoglycemic medications. The drug can increase the severity of side effects immunosuppressants , Cytostatics, hepatotoxic and nephrotoxic drugs. The risk of myelosuppression increases with simultaneous therapy drugs that inhibit the process bone marrow hematopoiesis .