Galvus

Description overdue on 11/22/2014

• Latin name: Galvus
• ATC code: A10BH02
• Active substance: Vildagliptin (Vildagliptin)
• Manufacturer: Novartis Pharma (Switzerland)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Galvus (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• The difference between the Galvus and Galvus Met
• With alcohol
• Reviews
• Price, where to buy

Composition

In tablets, the active substance contained vildagliptin   - 50 mg.

Additional components: MCC, anhydrous lactose, sodium carboxymethyl starch, magnesium stearate.

Product form

Galvus is produced in the form of round tablets smooth light-colored with markings «NVR» and «FB».

Tablets are packaged in blisters to 7 or 14 pieces, 2, 4, 8, 12 in the blister pack.

Pharmacological action

The drug has a hypoglycemic action.

Pharmacodynamics and pharmacokinetics

Substance vildagliptin   It is a stimulator of pancreatic islet apparatus capable of selectively inhibiting the enzyme dipeptidyl peptidase-4. The usefulness of this process increases the basal and stimulated secretion of food intake glucagon-like peptide-1 and glucose-type insulinotropic polypeptide from the gut into the systemic circulation. This increases the concentration of these components and the sensitivity of the β-pancreatic cells to glucose, the secretion enhancing glucose- insulin.

Elevated glucagon-like peptide-1 type may slow gastric emptying, but the treatment   vildagliptin   this effect was not observed.

Galvusom monotherapy or combined with reception metformin, thiazolidinedione Derived sulfonylureas   or insulin   for a long time it lowers the concentration of glycated Hemoglobin   and Glucose   blood. Also this treatment minimizes occurrences of hypoglycemia.

Ingestion absorption vildagliptin   It is fast enough. The absolute bioavailability of substances is 85%. The concentration of active ingredient in the plasma depends on the assigned dosing.

After taking the drug on an empty stomach its presence is detected in the blood plasma after 1 h 45 min. Food intake has little effect on the action of the drug. Inside the main part of the body is converted into Galvusa metabolites , Excretion which advantageously carried out by the kidneys.

Indications

The main indication for treatment is Galvusa Diabetes type 2   a mono- or combination therapy of different forms, for example, Metformin, thiazolidinediones   derivatives sulfonylureas   or insulin in the variational established by the attending physician.

Contraindications

This medicine is not recommended if:

• sensitivity vildagliptin   and other components of the drug;
• hereditary galactose intolerance, lactase deficiency galactose malabsorption glucose ;
• some cases of chronic congestive heart failure;
• the age of 18.

With care prescribe treatments to patients suffering from severe disorders of the liver and renal failure .

Side effects

Typically, the treatment Galvusom there is no severe adverse reactions requiring discontinuation of the drug.

However, we should not exclude the development of allergic reactions, especially in the form of edema. Possible liver problems, deviations in terms of the normal activities of the body. Also, the likelihood of retained hypoglycemia, headaches, dizziness, digestive disorders and general disorders of the body.

Instructions on Galvus (method and dosage)

This medicine is for oral administration and does not depend on the use of food. Dosage is adjusted individually, taking into account the efficiency and characteristics of the organism.

According Galvusa instructions for use, during monotherapy and in combination therapy with two- thiazolidinedione, metformin   or insulin   prescribe a daily dose of 50-100mg. In patients with severe Diabetes type 2 Receiving insulin Daily dose is 100 mg tablets Galvus.

Appointment of triple combination therapy, ie: vildagliptin + metformin + Sulfonylureas   It involves receiving 100mg per day. This usually takes at 50mg - morning and evening.

The two-component combination therapy sulfonylureas   It includes a daily dosage Galvusa constituting 50mg, which take in the morning. Possible to increase the daily dose to about 100 mg, but usually this is not required.

If there is insufficient clinical effects when receiving the maximum daily dose of 100 mg, then to control the further development of blood glucose, you can take other hypoglycemic agents, such as: metformin, thiazolidinedione, sulfonylurea derivatives or   insulin .

Overdose

Typically, patients tolerate Galvus with the intended daily dosage of 200 mg.

When you assign a daily dose of 400 mg may develop muscle pain, fever , Edema and other undesirable symptoms.

Increasing the daily dose to 600 mg may cause the development of swelling of limbs, a significant increase in the concentration of ALT, CK, C-reactive protein, and myoglobin . Usually after drug discontinuation the symptoms of overdose are eliminated.

Cooperation

It was found that for Galvusa characterized by a low potential for drug interactions. Therefore, it can welcome both substrates, inhibitors, inducers P450   and various enzymes.

Perhaps significant interaction of drugs with the drugs as prescribed for Diabetes mellitus type 2 , eg: Glyburide, metformin, pioglitazone . The results from the simultaneous use of drugs that have a narrow therapeutic range -   Amlodipine, digoxin, ramipril, simvastatin, valsartan, warfarin   It is not set, so such a combination therapy should be undertaken with caution.

Terms of sale

The drug prescription.

Storage conditions

For storage Galvusa designed a dry place not accessible to children, at a temperature of 30 C.

Shelf life

3 years.

Analogs

The main counterparts are presented drugs Galvus Met   and Vildagliptin.

The difference between the Galvus and Galvus Met

An important difference Galvus Met   by Galvusa it is that its members included the substance - metformin . At the same time, numerous studies have shown that the efficacy of treatment while taking this drug and separately tablets Metformin   and   Vildagliptin   considerably higher, and quite comfortable. In addition, patients taking combination drug no cases of severe hypoglycemia.

Alcohol and Galvus

During treatment with this drug should abandon the use of alcohol, as this may cause the development of unwanted symptoms and complications of the disease.

Reviews Galvuse

As the reviews of Galvuse forums devoted to medical subjects, the drug is one of the first, which is prescribed for a diagnosis diabetes . Perhaps for this reason, the patients do not know exactly how to take the medicine to therapy was effective.

In addition, at the initial stage of the disease, not all patients are serious about the other recommendations of the expert: compliance diet , Control of body weight and so forth, so often such a purpose is not performed. As a result, people are starting to feel the adverse symptoms and "jumps" blood sugar, all this trying to normalize the only reception of the drug.

Those who immediately reacted to the treatment of serious, say good efficiency Galvusa. Patients are told that they had to change some habits, but the quality of life is not particularly affected. Another problem is the high cost of the drug, which is why patients are forced to look for a replacement.

It is known that the normal state of health of patients diabetes It requires some effort from the man himself. Only through an integrated approach to their health can feel good about themselves and to prevent or significantly slow the development of disorders in the nervous and cardiovascular systems, which, unfortunately, often accompany diabetes.

Price Galvusa where to buy

Price Galvus 50 mg, 28 pieces, in pharmacies in Moscow varies between 720-800 rubles.

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