Description overdue on 04/07/2014
- Latin name: Curiosin
- ATC code: D10AX
- Active substance: Zinc hyaluronate (Zinci hyaluronas)
- Manufacturer: Gedeon Richter-RUS (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Kuriozin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Mass part of the main active ingredient of the drug Zinc hyaluronate It contains 1 gram of gel - 1, 027 mg / g.
If the drug is delivered in the form of solution , The dosage of the active substance is slightly higher and amounts to - 2 05 mg per 1 ml.
Composition gel added the following excipients to the pharmaceutical effect on skin was more effective and durable:
- Zinc chloride - 5 mg;
- potassium sorbate - 15 mg;
- Sodium Hydroxide - 30 mg;
- Carbomer - 150 mg;
- Water for injection to 15 g
If we are talking about solution Kuriozin Then as additional components are:
- potassium sorbate - 15 mg;
- sorbitol;
- Purified water for injection.
Product form
At the pharmacy shelves Kuriozin pharmaceutical preparation may be presented in two variations:
- Gel for external use a concentration of 0.103% of active ingredient. Liniment is placed in an aluminum tube with a white tip (PE) equipped with the perforating tip. Hole additionally protected by a thin membrane. It comes in a cardboard package.
- The solution Which is used for washing the wound defect and deep effect on the skin.
Pharmacological action
In order to understand how the drug has therapeutic effects in the treatment of acne we must first understand the pathogenetic factors of skin defects. First of all, the etiological component development acne It is sebaceous gland hyperplasia on the background hyperkeratosis excretory ducts . Thus follicles produce a secret that is not able to escape to the external environment, which is manifested as swelling and local adenitis . Also of great importance are the microorganisms Propionibacterium acnes . They produce biologically active substances that have an adverse effect on the duct-producing cells and their surrounding structures.
As a result of the above pathophysiological changes greatly reduced concentration hyaluronic acid surrounding sebaceous gland cover. This is a natural polymer, mucopolysaccharide of its chemical structure, which is an important structural component of connective tissue. Due to chemical and physical interactions, acid forms variance matrix Supporting the tone and elasticity of the superficial and deep skin covers. Also, the polymer is reacted with hyaluronic proteoglycans Stabilizing intercellular ground substance of connective tissue.
Zinc hyaluronate It eliminates the deficiency of the acid in the treated area of skin. This contributes to natural reproduction (similar to that of the natural chemical constituents) of the support framework for the cells. Thus the acid replaces the defective tissue, forming a basis for further development. Also increases the activity of hyaluronate granulocytes and macrophages That is, it stimulates the natural defenses against invasion of microorganisms (antiseptic effect of the drug). Zinc ions in turn have antibacterial effect Specifically aimed at Propionibacterium acnes . In response to the elimination of harmful microflora decreases the severity of the inflammatory process, which favorably affects the treatment of acne.
We should not forget that hyaluronic acid increases proliferative stage of development of fibroblasts . That is the main link activates the synthesis of new connective tissue, after which develops angiogenesis Providing newly reproduced dermal active portions inflow of arterial blood and useful nutrients including an additional portion of active forms of oxygen. Thus realized regenerating Kuriozin.
Pharmacodynamics and pharmacokinetics
Unfortunately, the pharmacokinetic properties of exogenous hyaluronic acid not enough is known, because its way into the connective tissue is difficult to trace. Also it is not possible to differentiate the external revenue from its own structural elements of the connective tissue, synthesized in response to the defeat.
Plasma concentrations of hyaluronic acid in normal individuals is in the range of 10-100 g / l, depending on the activity of reparative processes in the body. Elevated levels of biologically active component is celebrated in the morning, but the acid is rapidly cleared from the bloodstream. Splitting it into components of lower molecular weight takes place in the liver.
The half-life is 2, 5-5, 5 min. An interesting fact is that hyaluronates hardly excreted in the urine (found only 1 percent of the active ingredient). Her renal clearance is 320 micrograms per day.
Indications
Since the pharmaceutical preparation is available in several forms, the indications for use, and a little different, because the pharmacokinetic ability to largely depend on the method of using the drug, its bioavailability and the possibility of a complete adsorption sheets.
For example, gel (ointment) Kuriozin is more effective for the treatment of acne (acne) varying degrees of severity, because in such a pharmaceutical form of the drug is better interact with the surface of the skin elements. This therapy is primarily aimed at the rapid elimination of the inflammatory manifestations Acne or papulopustular rash . In a relatively short time disappears swelling, swelling, redness of the surrounding tissues. Temperature range surface to be treated as normal.
The solution Kuriozin On the other hand, has a pharmaceutical effect at deeper levels of organization (able to permeate through the basal layers of the skin more active than a gel or cream), and thus its efficiency in the treatment of the above trophic ulcers . Use the solution and a slow healing Wounds . bedsores and Fistula As it stimulates the flow of nutrients to the skin from the inside. Positive therapeutic effect was also observed with the rehabilitation infected defects Because thus more effective in stimulating the immune system of the body, which contributes to the rapid disposal of harmful microorganisms by macrophages and granulocytes.
Applications for gel Kuriozin wrinkles is not an absolute indication from a medical point of view, however, cosmetologists actively recommend the use of a pharmaceutical formulation for the purpose of smooth skin . Effect of the drug actually helps facial rejuvenation , Improve the blood supply to the microvasculature and greater nutrition of the dermis and epidermis, a positive effect on the appearance of the skin. Reviews Kuriozin wrinkles in particularly difficult areas of skin confirms the favorable effects of pharmaceuticals. After a relatively short course of treatment is enhanced elasticity, and his face looks more healthy and fresh. How to use gel to get rid of unpleasant folds can be found in the relevant section (see. Dosing).
Contraindications
Hypersensitivity idiosyncrasy or intolerance to one or more components of the pharmaceutical preparation.
Side effects
- Dermahemia (increased blood flow, which stains covers characteristic redness of the surface layers of the epithelium by the nearby vascular bed);
- Unpleasant sensations burning ;
- Feeling tautness and dryness of the skin ;
- Stretching the treated area;
- Allergic reactions ( itching . hives . angioedema adjacent tissue, and so forth).
Instructions on Kuriozin (method and dosage)
A method of using the pharmaceutical formulation as indications, vary somewhat depending on the form of the drug. So before applying solution should treat the wound with plenty of isotonic solution sodium chloride or 3% hydrogen peroxide . This will provide a more complete Kuriozin action. The solution is applied directly to the wound 1 whether 2 times a day according to individual indications. If the skin defect is localized in the crook and simply rinse it is not convenient, it can be impregnated with a solution of cotton or gauze and then apply it to the wound.
Gel Kuriozin, instructions for use:
Provision pretreatment skin mechanically (thorough washing with warm water). Next to the copious amounts of ointment applied to the affected skin. Repeat procedure should be twice a day. It is recommended that treatment in the morning and lunch hours, marking the peak metabolic activity hyaluronic acid .
Overdose
Overdose cases in clinical practice are not described.
Cooperation
Adverse drug interactions with other groups during the combined therapy are not registered, but before the joint use of several drugs recommended to check with your doctor or qualified pharmacist about the possibility of their simultaneous use.
Terms of sale
Sold in the pharmacy without a prescription form.
Storage conditions
The drug, regardless of the form of release, should be stored in a dry place inaccessible to young children place at constant temperature of 17 to 30 degrees Celsius. When you open a bottle of solution you want to use it for a month, or the pharmaceutical properties of the active ingredients come to naught.
Shelf life
2 years.
Cautions
A positive feature of the product is that the gel does not leave any traces on the clothes and does not stain the skin (not cause as temporary and permanent pigmentation of the skin).
Analogs Kuriozin
With Klenzit
Kuriozin - to a certain extent unique pharmaceutical preparation. Its therapeutic action is aimed at activation of reparative processes of the body In particular the elimination of defects of the skin, but is not limited to the broad spectrum of drug administration. Using gel for cosmetic purposes does give positive results, because the drug is widely used for medical facial rejuvenation, giving the skin a healthy color and elasticity required. This the Philosopher's Stone, which has long been searching for most of the alchemists, selflessly Dreaming on the extension of youth.
During pregnancy and lactation
Clinical studies that would prove safety of the gel or solution Kuriozin not carried out because drug use in pregnancy or lactation should be only if absolutely indicated and a qualified person under medical supervision, so that in the event of adverse effects of treatment, assistance was provided in a timely manner.
Reviews Kuriozin
Reviews Kuriozin face full of gratitude recommendations. The product allows you to eliminate of infection Get rid of unpleasant, sometimes even disfiguring defects with a minimum range of side effects.
Severe side effects of treatment are extremely rare, only in the hereditary hypersensitivity to the ingredients of the drug (in this case experienced experts recommend carrying out an allergy test before the start of medical treatment), because the solution as a liniment, leaves only pleasant impressions after passed course of treatment even if clinically severe pathology (eg, preparation of forces to cope with the deep trophic ulcers Infected with malicious microflora).
Reviews from gel Kuriozin wrinkles confirm positive cosmetic effect of the pharmaceutical preparation. In a short time the complex therapy ointment eliminates the folds of the skin, even in the most difficult places, such as the lateral edge of the eye sockets, the lateral surfaces of the forehead and the corners of his mouth. Also happy drug women in their recommendations, adding that the complexion becomes more healthy and rosy cheeks, due to active stimulation of blood circulation covers.
How gel for acne The drug meets the youthful age segment. Get rid of acne by conservative - a relatively difficult task, because the microorganisms are constantly evolving and resistance to a number of traditional medicines - a serious problem of drug therapy in dermatology. Kuriozin also allows you to eliminate acne in a short course of treatment. Separately, it is worth noting that the skin is becoming more flexible, thereby to care for a person in the future much easier.
Price Kuriozin where to buy
Price pharmaceutical preparation is practically independent of the release form, as opposed to reading or pharmacokinetic abilities. For example, the price gel Kuriozin the Russian Federation is an average of 400 rubles, topical solution It can be bought for 380 rubles.
Cost Gel of wrinkles Kuriozin It may involve higher levels, as the pharmaceutical agent of this kind is sold mainly in beauty salons. In Ukraine, the cost is 80 hryvnia, while ointment for acne It can be purchased for 50 hryvnia.
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