Description overdue on 11/23/2014
- Latin name: Galvus Met
- ATC code: A10BD08
- Active substance: Vildagliptin + metformin (Vildagliptin + Metformin)
- Manufacturer: Novartis Pharma Productions GmbH., Germany; Novartis Pharma Stein AG, Switzerland
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications for use drugs
- Contraindications
- Side effects
- Galvus Met - application instructions (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
The tablets contain the active ingredient: vildagliptin and metformin hydrochloride .
Additional components: giproloza, hypromellose, magnesium stearate, titanium dioxide, talc, macrogol 4000, iron oxide yellow and red.
Product form
Produced Galvus Met in the form of tablets, coated foil liner at a dosage of 50 mg to 500 mg + 50 mg + 850 mg + 50 mg or 1000 mg. The tablets are packed into blisters of 6 or 10 for 1, 3, 5, 6, 12, 18, 36 blister packaging.
Pharmacological action
This hypoglycemic drug has pharmacological effect.
Pharmacodynamics and pharmacokinetics
Galvus Met includes in its membership 2 hypoglycemic agents with different mechanisms of action. Wherein vildagliptin an inhibitor of dipeptidyl peptidase-4 (DPP-4) and metformin hydrochloride refers to biguanide . In combination, these components contribute to the effective monitoring for a day of glucose in the blood when type 2 diabetes mellitus.
Using this formulation leads to a statistically significant permanent reduction in blood glucose concentration. At the same time marked only isolated cases of hypoglycemia.
It is found that the consumption of food has no effect on the rate and extent of drug absorption and the concentration of active substances is somewhat reduced, but, in general, dependent on the dose received.
Absorption occurs quickly Galvus Met, components bioavailability is about 85%. When the medicine is taken on an empty stomach, the presence of its components in the blood plasma is revealed through 1-1, 5 hours. In the body the drug is converted to metabolites Which are output by the kidneys and a small part of the feces.
Indications for use drugs
The main indication for reception Galvus Met is therapy for Diabetes mellitus type 2 in cases where:
- monotherapy vildagliptin or metformin It is not effective;
- fails to adequately control glycemia when other treatment options and so on.
Contraindications to the use of
Galvus Met is not indicated for:
- High Sensitivity to its components;
- renal failure and other violations in the work of the kidneys;
- acute forms of diseases that can cause the development of renal dysfunction - dehydration, fever, infections, hypoxia and so on;
- violations of the liver;
- Diabetes mellitus type 1 ;
- chronic alcoholism , Acute alcohol poisoning;
- Lactation . pregnancy ;
- compliance hypocaloric diet ;
- Children up to age 18 years.
Precautions tablets administered to patients from 60 years of working on heavy physical production, as may develop lactic acidosis.
Side effects
In the treatment Galvus Met may develop adverse events that occur: strong headache . dizziness . tremor . Also, there may be irregularities in the activity of the gastrointestinal tract: nausea, diarrhea, gastro-oesophageal reflux, flatulence . Although the reception of the drug minimizes the appearance hypoglycemia Should not exclude the development of its symptoms.
Galvus Met - application instructions (method and dosage)
This drug is intended for oral administration. Galvus Met dosage is adjusted individually and depends on the efficacy and tolerability of components. During therapy is recommended to strictly comply with assigned a daily dose vildagliptin Which should not exceed 100 mg.
At the beginning of the treatment dose is selected taking into account the duration of the disease, the level of glycemia , The patient's condition and used until this therapeutic regimen. To reduce the severity of side effects associated with the digestive system, the drug is taken with food.
Generally, treatment is initiated with one tablet of 50 mg + 500 mg, which is taken 2 times a day. After evaluating the therapeutic effect and gradually increase the dosage can.
If monotherapy metformin proved to be ineffective, then in view of the previously received metformin Can be assigned to one tablet the most suitable dosage for reception, 2 times a day.
In the appointment of the initial dose of the drug in patients receiving combination therapy with individual tablets vildagliptin and metformin Picked as close dosing.
In the combined therapy Galvus Met and derivatives sulfonylureas or insulin counting the number of dose vildagliptin 50mg × 2 times, i.e. 100 mg per day, and metformin at a dose approximating the received in monotherapy.
Overdose
As is known, vildagliptin as part of the drug is well tolerated when taken in daily dosing up to 200 mg. In other cases it may cause muscle pain and swelling fever . Usually the symptoms of overdose can be eliminated by the abolition of the drug.
In cases of overdose metformin Symptoms that may develop while taking the drug between 50 g, may experience hypoglycemia . lactic acidosis Followed by nausea, vomiting, diarrhea, a decrease in body temperature, abdominal pain and muscle pain, rapid breathing, dizziness. Severe forms lead to a breach of consciousness and Development coma .
This symptomatic treatment performed by procedure Hemodialysis and so on.
It should be noted that for patients who receive insulin , The appointment of Galvus is not a substitute Met insulin.
Cooperation
Vildagliptin It does not apply to substrates of cytochrome P450 It is not an inhibitor of these enzymes and the inductor, so virtually no interaction with substrates, inducers or ingibitoramiR450. Moreover, its concurrent use with substrates of certain enzymes does not influence the rate of metabolism these components.
Also, simultaneous use vildagliptin and other drugs prescribed for Diabetes mellitus type 2 , for example: glibenclamide . pioglitazone, metformin and drugs with a narrow therapeutic range - amlodipine, digoxin, ramipril, simvastatin, valsartan, warfarin It does not cause a clinically significant interaction.
The combination furosemide and metformin It has a reciprocal influence on the concentration of these substances in the body. Nifedipine increases absorption and elimination metformin in urine composition.
Organic cations , such as: Amiloride, digoxin, procainamide, quinidine, morphine, quinine, Ranitidine, Trimethoprim, Vancomycin, triamterene and others, in the interaction with metformin due to competing for common renal tubular transport may increase its concentration in the composition plasma . Therefore, the use of Galvus Met in such combinations requires caution.
The combination of the drug with thiazide , Other diuretics, phenothiazines . preparations of thyroid hormones, estrogens, oral contraceptives . phenytoin, nicotinic acid . sympathomimetics, calcium channel blockers and isoniazid , Can provoke hyperglycemia and reduce the effectiveness of hypoglycemic agents.
So when administered simultaneously or cancel these drugs require careful monitoring of the effectiveness of metformin - Its hypoglycemic action and if necessary correction of dosage. By coupling with danazol to refrain, to avoid the appearance of his hyperglycemic action.
Receiving high doses chlorpromazine can improve glycemia, as it reduces the release of insulin. Carrying out treatment neuroleptics also requires correction dosing and monitoring the concentration of glucose.
Combination therapy with iodine-containing radiopaque resources For example, conducting radiological studies of their use, often causes the development of lactic acidosis in diabetes and functional renal failure.
Increase glycemia able to inject β2-sympathomimetic resulting from stimulation of β2-receptors. For this reason the need to control glycemia Possibly appointment insulin.
Simultaneous treatment with metformin and sulfonylureas . insulin, acarbose . salicylates It can enhance the hypoglycemic effect.
Terms of sale
Prescription medications.
Storage conditions
Tablets should be stored in a dark, dry place, away from children, at temperatures up to 30 ° C.
Shelf life
18 months.
Analogs Galvus Met
Amaryl M
The main counterparts of the drug presented medications: Galvus and Vildagliptin .
Alcohol and Galvus Met
In the treatment of this drug is recommended that a complete rejection of the use of alcohol-containing beverages. As is known, in such cases, alcohol causes the development of side effects and lead to complications of the disease.
Reviews of Galvus Met
As the reviews of Galvus Met (although many people mistakenly think that the name of the drug - "Galvus Honey"), the drug is prescribed to many patients suffering from type 2 diabetes mellitus . However, it takes it usually those people who have been diagnosed with the disease recently. Often they say that this therapy allows them to normalize the state of health and prevent the development of undesirable symptoms, followed within Diabetes .
Of course, some reviews of drugs is a confirmation of its effectiveness, but users complain about the high cost of medicines. Therefore, despite the fact that the pill helps a lot, they have to replace the other, cheaper.
Simultaneously, there are descriptions of characteristics of the drug, and other ways to maintain the normal state during diabetes . This indicates that the treatment in such cases should be done comprehensively.
Price Galvus Met, where to buy
This drug can be bought in Moscow in almost any pharmacy or online pharmacy. The price of Galvus 50 mg plus 1000 mg per 30 pieces varies between 1180-1400 rubles.
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