Description overdue on 08/10/2014
- Latin name: Fosicard
- ATC code: C09AA09
- Active substance: Fosinopril (Fosinopril)
- Manufacturer: Actavis Group hf., Iceland
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Fozikarda
- Contraindications
- Side effects
- Fozikard - application instructions (method and dosage)
- Overdose
- Cooperation
- Cautions
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Tablets Fozikard H
- With alcohol
- Reviews
- Price, where to buy
Composition
Each tablet contains Active ingredient: Fosinopril sodium.
Auxiliary ingredients: lactose monohydrate, pregelatinized corn starch, sodium Valium, MCC and glycerol dibehenate.
Product form
Available Fozikard in the form of tablets, which contains 5, 10 or 20mg of the main substance, packaged 10 pieces in blisters, nested 3 pieces per pack.
Pharmacological action
The drug has vasodilating and hypotensive action.
Pharmacodynamics and pharmacokinetics
The drug has a pronounced anti-hypertensive and vasodilator effect. Its main component is metabolized within the body, whereby a pharmacologically active substance - fozinoprilat . The mechanism of therapeutic action of inhibition of the activity seen angiotensin-converting enzyme That can prevent the transition Angiotensin-I at angiotensin-II It is having a noticeable effect vazokonstrikornym. Also slowing the decay bradykinin That can expand blood vessels. This decreases total peripheral vascular resistance, decreases arterial pressure , Pre- and afterload myocardium .
These tablets are well absorbed in the gastrointestinal tract. Development of therapeutic effect occurs within an hour, the maximum concentration is achieved after 2-6 hours and lasts approximately 24 hours, even after a single application. Long-term use is not conducive to the development of tolerance fosinopril . For this substance has a higher degree of binding to plasma proteins, about 95%. Withdrawal fozinoprilata It occurs by means of the kidneys and liver. The average half-life of up to 11, 5 hours.
Indications Fozikarda
The main indications for use Fozikarda:
- congestive heart failure;
- arterial hypertension.
Contraindications
Do not take this medicine if:
- hypersensitivity fosinopril and other components;
- hereditary or idiopathic angioedema ;
- lactation, pregnancy ;
- the age of 18.
Be careful if you need to:
- renal insufficiency;
- hyponatremia;
- bilateral renal artery stenosis and solitary kidney artery;
- condition after kidney transplantation, desensitization, some connective tissue diseases;
- hemodialysis;
- cerebrovascular diseases, such as cerebrovascular insufficiency;
- diabetes;
- aortic stenosis;
- suppression of bone marrow hematopoiesis;
- the elderly and so on.
Side effects
When treating Fozikardom may experience side effects affecting the activities of all systems and organs. For example, cardiovascular system It can respond to lower blood pressure, orthostatic hypotension, tachycardia, palpitations, arrhythmia, angina, heart attack and chest pain.
Also, deviations in the Digestive System such as nausea, vomiting, constipation, ileus, pancreatitis, hepatitis, stomatitis, glossitis, dyspepsia, abdominal pain, anorexia and so on.
In addition, it is possible the emergence of disorders associated with the activity respiratory, urinary and Nervous system .
There remains the probability of defeat about Organ Precursor feelings of allergic reactions and changes in laboratory parameters .
Fozikard - application instructions (method and dosage)
Fozikard tablets intended for ingestion. Generally, the dosage and duration of treatment is chosen individually, but there are several standard rules.
According to the instructions for use Fozikarda, during therapy hypertension It is advised to stop taking any antihypertensive drugs.
The initial daily dosage of the preparation time is 1 to 10 mg. Later required dose selection, taking into account indicators of AD. While maintaining the daily dose may be 1 time by 10-40 mg. If Fozikardom monotherapy is not effective, it is permissible to join diuretic .
When people start taking this medication along with the diuretic Then prescribe a starting dose of 10 mg, performing a thorough medical supervision of the patient.
During the treatment of chronic heart failure sets the initial daily dose of 10 mg. Gradually operate weekly dose increase to 10 mg. The maximum dosage should not exceed 40 mg / day. Also possible further reception diuretic .
Overdose
Cases of overdose can cause marked lowering of blood pressure, bradycardia, shock, disruption of water and electrolyte balance, acute renal failure, or stupor.
At the same time you want to stop the use of Fozikarda, put the patient lifting his legs and conduct symptomatic treatment. In mild cases of overdose would be sufficient gastric lavage, the use of adsorbents sodium sulfate.
Cooperation
Simultaneous use of the drug with antihypertensive means diuretics, narcotic analgesics, general anesthesia able to strengthen hypotensive effect fosinopril.
Combination with potassium supplements and some potassium-sparing diuretics increase the likelihood of hyperkalemia . The simultaneous use of lithium salts increases the concentration of lithium in the blood.
Fozikard increases hypoglycemic effect of sulfonylureas, insulin, increases the risk of leukopenia symptoms in cases of simultaneous use with allopurinol . immunosuppressants, cytotoxic drugs, procainamide . The combination with NSAIDs and estrogens reduce the severity of the hypotensive action.
Cautions
Fozikardom treatment of patients suffering from severe hypertension or decompensated chronic Heart Failure It is recommended to start in the hospital. This therapeutic process requires monitoring of blood pressure, kidney function, the content hemoglobin, ureas and creatinine , The concentration of electrolytes and potassium, the activity of liver enzymes in the blood.
It is also necessary to periodically monitor the number leukocytes Especially if there is a risk neutropenia For example, in cases of renal dysfunction or systemic connective tissue diseases.
Possible increase of arterial hypotension requires compliance with caution when the drug is prescribed to patients who are on a salt-free diet or malosolevoy.
Supplementation of the drug may cause dizziness, usually at the beginning of treatment in combination with diuretics , So you need to be careful in activities requiring special attention or when driving.
Terms of sale
Fozikard prescription.
Storage conditions
To store the tablets meant a dark place at a temperature up to 30 ° C, well protected from children.
Shelf life
2 years.
Analogs Fozikarda
Captopril
Monopril
Renitek
Charter
Amprilan
Ramipril
Perindopril
Prestarium
Perineva
Capoten
Berlipril
Akkupro
Diroton
Enap
Enalapril
The main counterparts are presented drugs Monopril, Fozinotek and Fozikard H . Also, have a similar effect: Enalapril, Prestarium . Captopril and Lisinopril.
Tablets Fozikard H
The difference of this drug lies in its composition, which comprises fosinopril sodium and additional material - hydrochlorothiazide . It determines its pharmacological effect - antihypertensive, potassium-sparing, vazodilatirtee and diuretic .
Alcohol
During treatment Fozikardom to refrain from drinking alcohol, which can lower its hypotensive effect.
Reviews Fozikarde
This drug is usually prescribed for hypertensive disease But it should be understood that such treatment does not make a full recovery. At the same time feedback on Fizikarde show that combined therapy of this equipment is a patient who is worried about the disease for several years.
According to experts, the treatment of hypertension requires the right approach and perseverance. Therefore, patients should be observed prescription without breaking the therapeutic regimen or stopping treatment alone. In addition to receiving drugs necessary to maintain a healthy lifestyle, to perform procedures that will enhance the vessels.
Price Fozikarda where to buy
Price Fozikarda ranges 107-237 rubles and depends on the content of the tablets amounts of active substance.
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