Aspikor

Description overdue on 30.04.2013

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Nonsteroidal anti-inflammatory drugs . The drug in the indiscriminate manner inhibits the activity of enzymes cyclooxygenase   1 and 2 (regulate prostaglandin synthesis). The drug Aspikor has analgesic (pain relief), anti-inflammatory and antipyretic effects. The active substance acetylsalicylic acid inhibits the formation of prostaglandins, which are formed by the action of hyperalgesia   and swelling. Reduced levels of prostaglandins in the main center   thermoregulation   (preferably E1) causes sweating, widening of the lumen of the blood vessels in the skin and, as a consequence, reduction in body temperature. The analgesic effects achieved by peripheral and central actions of the drug. Aspikor suppresses synthesizing thromboxane   A2 cells in blood platelets, lowers thrombosis , Platelet adhesion and aggregation . In patients with unstable angina over the active ingredient acetylsalicylic acid reduces the mortality risk of myocardial infarction. Antiplatelet effect lasts for about a week after a single dose. The daily dosage of 6 grams or more increases in prothrombin time, inhibits the synthesis of prothrombin   in liver tissue. Aspikor medicine increases the frequency of bleeding complications during surgery. Under the influence of the drug increases the excretion Uric acid   (as a result of violations of tubular reabsorption in the kidney). Aspikor available in tablet dosage form (enteric, effervescent, children, in the shell).

Indications:

The medicine is prescribed for the relief of Aspikor pain (mild to moderate severity forms) different proichozhdeniya: migraines, headaches, myalgia , Radicular syndrome, algomenorrhea , Arthralgia, lumbago, neuralgia, toothache. The drug is used in a feverish syndrome on the background of infectious diseases, inflammatory diseases.

Contraindications:

Tablets are not prescribed for Aspikor hemorrhagic diathesis If the individual form of intolerance to aspirin, bronchial asthma, bleeding from the digestive tract, erosive and ulcerative lesions of the digestive system, concurrent therapy with methotrexate, pregnancy (the first, third trimesters), lactation and children up to the age of fifteen.

Side effect:

Aspikor pills can cause diarrhea, nausea, allergic responses in the form of angioedema, skin rash and bronchospasm . The treatment may be in violation of the kidneys and liver system development Reye's syndrome   (rapid formation of liver failure, liver disease, and encephalopathy), leukopenia, thrombocytopenia , Severe anemia. Long-term therapy may be accompanied by anticoagulation , Erosive and ulcerative lesions of the gastrointestinal tract, dizziness, migraine, vomiting, impaired vision,   interstitial nephritis , Bleeding, papillary necrosis, pre-renal azotemia and hypercalcemia hypercreatininemia, swelling, increasing symptoms of heart failure, aseptic meningitis, increased liver enzymes, nephrotic syndrome .

Mode of application:

Aspikor tablets taken orally. When pain, fever syndrome   medication taken orally up to 3 grams (the recommended dose of 0, 5-1 grams per day) for 3 doses. As analgesic and antiinflammatory Aspikor administered at a dose of 325 mg. Duration of therapy should not exceed more than two weeks. Effervescent medication form must be pre-dissolved in 100-200 ml of water. A one-time amount of drug 0, 25-1 grams (3-4 times a day).

Special instructions:

Use of the drug as an anti Aspikor medicament is limited because of the high risk of developing NSAID-gastropathy. Duration of therapy should not exceed more than 5 days. Responses to the drug Aspikor show good tolerability and high efficacy in compliance with all recommendations. Currently, the drug is not prescribed for Rheumatic chorea , Infectious form of allergic myocarditis In rheumatoid arthritis, as well as rheumatism and pericarditis. Aspikor recommended to cancel 5-7 days prior to elective surgery. Long-term treatment requires mandatory control blood counts, fecal occult blood. The drug is able to provide teratogenecity . Aspirin is excreted in breast milk. The drug can cause an acute attack of gout. The price of the drug Aspikor is 50 rubles. Analogs Aspikora: tromboASS, atsekardol . cardiomagnil .

Drug Interactions:

Drug Usage Aspikor does not recommend medication along with oral hypoglycemic agents, valproic acid . Methotrexate , Antiplatelet agents, thrombolytics,   indirect anticoagulants , Heparin, sulfonamides, and urikozuricheskimi antihypertensive agents, diuretics. The risk of gastrointestinal bleeding increases with concurrent therapy with glucocorticosteroids and ethanol-containing medicines. Aspikor able to increase the concentration of barbiturates, digoxin, lithium salts in the plasma. Absorption of acetylsalicylic acid reduces the treatment antacids . Gematotoksicheskim Aspikora influence increases in the treatment of myelotoxic drugs.