Description overdue on 08/31/2014
- Latin name: Ketosteril
- ATC code: V06DD
- Active substance: Ketoanalogi amino acids (Ketoanalogues of aminoacids)
- Manufacturer: Fresenius Kabi Deutschland GmbH (Germany)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Ketosterila
- Contraindications
- Side effects
- Instructions for use Ketosterila
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Reviews
- Price, where to buy
- Selling Ketosteril for cats
Composition
Tablets of coated films 1 tablet contains active ingredients: alpha ketoanalog isoleucine 67 mg . alpha ketoanalog leucine 101 mg . alpha ketoanalog phenylalanine 68 mg . alpha ketoanalog valine 86 mg . alpha-hydroxy analog of methionine 59 mg . L-lysine monoacetate 105 mg . L-threonine 53 mg . L-tryptophan 23 mg . L-histidine 38 mg . L-tyrosine 30 mg .
Excipients: corn starch, polyvinylpyrrolidone, talc, colloidal silica, magnesium stearate, polyethylene glycol 6000, soluble polyvinylpyrrolidone.
Composition shell talc, polyethylene glycol 6000, quinoline yellow, methyl methacrylate, butyl methacrylate and dimethylaminoethyl methacrylate, triacetin, titanium dioxide.
Total 1 tablet contains 36 mg of nitrogen and 50 mg of calcium.
Product form
Oval convex on both sides of the tablet in a yellow envelope from the film, produced in a carton of 100 pieces - 5 blisters of 20 pieces. in a sealed package made of aluminum, placed in a cardboard box.
Pharmacological action
Ketosteril (INN - ketoanalogi amino acids) helps to restore metabolism, impaired due to inadequate intake of essential amino acids to the damage of the kidneys. It promotes protein synthesis in the body, reduces the toxic effects of products of protein metabolism in the body, improves the general condition of patients with chronic renal impairment.
Pharmacodynamics and pharmacokinetics
Ketosteril - Is a drug, which is composed of essential amino acids, without which the body can not function properly. Assign it in violation of the kidneys on a background of destruction of kidney tissue and a gradual increase in the blood levels of toxic metabolic products, mainly protein.
In the blood of patients revealed a large amount of residual nitrogen and its components have toxic effects on the body. Residual Nitrogen - A set of non-protein nitrogen (metabolic products of protein in blood plasma), consisting of urea amino nitrogen , Uric acid, creatine, and creatinine.
Violation of protein metabolism leads to the fact that the body does not receive vital amino acids , While the blood in a large amount accumulate toxic products of protein metabolism. In order to reduce the toxic load on the body, patients are administered with a protein-restricted diet that leads to protein starvation.
Ketosteril supplying body essential amino acids (including the human body are constructed proteins), but the number of the incoming nitrogen is thus limited. This happens due to the fact that the composition includes ketosteril ketone analogs of amino acids, which are rapidly absorbed by the body and help with the disposal of toxic products of protein metabolism.
This helps to improve the mechanism of action of the protein and mineral metabolism, and hence the patient's general condition.
The pharmacokinetics of the drug has not been studied, since all its components are natural components of metabolism and trace their movement in the body impossible.
Indications Ketosterila
The drug is prescribed for the prevention and treatment of disorders of protein and mineral metabolism with chronic renal dysfunction in adults and children over 3 years.
The indication for use is the reduction Ketosterila glomerular filtration rate to 25 ml / min or less. But the drug can also be used in the early stages of the disease when the glomerular filtration rate only begins to decline (the norm - 100-120 ml / min).
Contraindications for use Ketosterila
Ketosteril should not be prescribed if you are hypersensitive to its components, elevated levels of calcium in the blood and metabolism of amino acids (for example, phenylketonuria In which the exchange of the amino acid phenylalanine is broken) and children up to 3 years.
With caution is prescribed for drug pregnancy Because clinical trials have not been conducted in pregnant women.
Side effects Ketosterila
The drug was well tolerated and rarely has side effects. However, they may be in the form of hypercalcemia - increased blood levels of calcium.
Hypercalcemia It manifested in the form of weakness, nausea, vomiting, high blood pressure; the patient drinks a lot of fluid and emits a lot of urine; hypercalcemia in patients with chronic kidney grows connective tissue and form stones.
Instructions for use Ketosterila
The drug is taken orally during meals. Tablets should be swallowed whole, while drinking plenty of fluids - so they are best absorbed and included in the metabolic processes.
Dosage appointed in accordance with the weight patient rate of 1 tablet per 5 kg per day. The daily dose divided into 3-4 receptions. The average daily intake for an adult 12 - 24 tablets.
Instructions to carry out Ketosteril offers a course of treatment throughout the period of declining glomerular filtration rate below 25 ml / min. At the same time assigned a diet with a reduced amount of protein. Chronic administration Ketosterila should periodically check the content of calcium in the blood.
Ketosterila Interaction with other drugs
Ketosteril can not be used simultaneously:
- with calcium - this can lead to hypercalcemia;
- with drugs that form sparingly soluble compounds with calcium - antibiotics groups tetracyclines , Antibiotics group quinolones , Drugs, which include iron, estramustine and fluorine ; between taking these drugs and Ketosterila should be a gap of at least two hours.
While improving the condition in patients receiving Ketosterila in order not to disturb the acid-base balance should gradually reduce the dose of aluminum hydroxide, which is prescribed for acidosis (shift of acid-base balance in the body in the direction of increasing acidity).
Terms of sale
The preparation is available on medical prescription.
Storage conditions
Tablets should be kept in a dry place, while respecting the temperature above 25 ° C. The storage location must not be accessible to children.
Shelf life
The drug is stored for 3 years, subject to the above conditions.
Analogs Ketosterila
Analogs - a variety of dosage formulations groups which are used to treat the same disease. Analogues Ketosterila not. The uniqueness of this product is that it not only provides the body necessary for protein synthesis amino acids But also helps to reduce the blood levels of toxic products of metabolism of proteins.
Reviews Ketosterile
Ketsteril - a drug that is used in a complex treatment of patients with impaired kidney function. Almost all patients who receive it, there is a gradual improvement in general condition, confirmed by laboratory tests.
Negative reviews Ketosterile there is little, but some patients reported that improvement is too slow, it is likely to be associated with disease severity.
Price Ketosterila
Price Ketosterila (100 tablets) in Moscow varies from 2,250 to 3,482 rubles. Buy cheap Ketosteril in Moscow (for 2250 rubles) can be in the e-pharmacy (pharmacy chain, located at 54 addresses).
Selling Ketosteril for cats
Recently Ketosteril increasingly began to apply for the treatment of cats in violation of the kidneys. Many very well speak about this drug - it can greatly facilitate the condition of pets. And as for cats require much less tablets than for men, the remaining tablet owners often try to sell. That's just whether to buy drugs with it, because today so many fakes?
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