Description overdue on 03/07/2014
- Latin name: Floxal
- ATC code: S01AE01
- Active substance: Ofloxacin (Ofloxacin)
- Manufacturer: Dr. GERHARD MANN Chem.-Pharm. Fabrik, GmbH (Germany)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Floksala
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
- Eye drops Floksal 0, 3% contain 1 ml ofloxacin - 3 mg. Excipients: benzalkonium chloride solution hydrochloric acid, sodium chloride, solution sodium hydroxide Water.
- Eye ointment Floksal 0, 3% in 1 g contains ofloxacin in an amount of 3 mg. Other ingredients: liquid paraffin; wool grease; white petrolatum.
Product form
Eye drops represent a clear solution of pale yellow color. 5 ml of this solution in a plastic bottle with a lid dropper, a bottle in a carton box.
Eye ointment generally homogeneous, pale yellow. 3 g of the ointment in a tube, one such tube in a carton box.
Pharmacological action
The drug has antibacterial effect .
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Ofloxacin It is fluoroquinolone (derivatives quinolone acid ) antibacterial drug , Has a bactericidal effect.
The spectrum antibacterial action ofloxacin : Facultative anaerobes, obligate anaerobic, aerobic and some other bacteria, e.g. Chlamydia .
The incidence of acquired resistance of certain types of microorganisms varies according to region and changes over time. Therefore, the main purpose for the proper treatment of infections is the possession of information about the local resistance. Possible cross-resistance ofloxacin and other fluoroquinolones .
The most sensitive species:
- Gram-positive aerobic bacteria Staphylococcus aureus, Bacillus spp. ;
- Gram-negative aerobic bacteria Acinetobacter lwoffi, Acinetobacter baumannii, Escherichia coli, Haemophilus influenzae, Klebsiella oxytoca, Enterobacter cloacae, Proteus mirabilis, Haemophilus parainfluenzae, Moraxella catarrhalis, Klebsiella pneumoniae, Serratia marcescens .
Species for which acquired resistance may be present:
- Gram-positive aerobic bacteria Enterococcus faecalis, Corynebacterium spp., Metsitilenrezistentnye strains of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis ;
- Gram-negative aerobic bacteria Stenotrophomonas maltophilia, Pseudomonas aeruginosa .
The species has an innate resistance:
- Gram-positive aerobic bacteria Enterococcus spp .
Pharmacokinetics
Efficacy depends on the ratio of its highest concentration in the tissue and the minimum inhibitory concentration of the pathogen.
Repeated use of the drug accumulates in the vitreous therapeutic concentrations. After administration 5 times a day with an exposure of 5 minutes, 1-2 hours in aqueous humor concentration becomes maximum, and another 5-6 hours, it decreases to zero.
The half-life Floksala from the blood when used regularly, is from 3 to 7 hours.
Indications
Infectious diseases of the anterior part of the body, caused by microorganisms sensitive to the drug:
- helcoma ;
- barley ;
- blepharitis ;
- conjunctivitis ;
- keratitis ;
- dacryocystitis ;
- Chlamydia eye disease.
As well as prevention and treatment of infectious complications after surgery, and eye injuries.
Contraindications
- Breast-feeding .
- Gestation .
- Allergies to the drug.
Side effects
Pronounced reactions after regular use ofloxacin They occur rarely, most of them reversible.
Immediately after using the drug may appear blurred vision, which disappears after a few minutes.
- On the side immunity : conjunctival hyperemia . angioedema , A burning sensation in the eye, anaphylactic reaction oropharyngeal edema .
- On the side Nervous System : dizziness .
- On the side eyes : Discomfort in the eyes, irritation, keratitis , Blurred vision, conjunctivitis , Photophobia, dry eyes, tearing.
- On the side digestive organs Nausea.
- On the side skin : Swelling of the face and periorbital area.
There is evidence that the local use very rarely develop Stevens-Johnson syndrome and toxic epidermal necrosis . The causal relationship of these symptoms with ofloksotsinom is not set.
Instructions for use Floksala
Eye drops Floksal prescribed instructions for use apply 1 drop of patient's eyelid eyes 3-4 times a day.
Instructions eye ointment Floksal also recommends the use of the drug conjunctival. A strip of ointment to 1, 5 cm lay in the conjunctival sac 2-3 times a day, with the defeat of chlamydia - 5 times a day. The ointment and eye drops is not recommended for more than 2 weeks.
You can combine eye ointment and drops Floksal. When sharing the local reception of more than one drug ointment should be used last.
Overdose
Reported cases of overdose was not. Therapy - symptomatic , You need to quickly rinse the eyes with clean water.
Cooperation
Features of interaction have not been studied.
Terms of sale
The drug is sold only by prescription.
Storage conditions
Keep away from children. The drug should be stored dark at 25 ° C. After opening the tube or vial and the drug can be used no more than 6 weeks.
Shelf life
3 years.
Cautions
If there allergic reaction Floksal on, reception should be stopped.
Prior to the first administration of the drug is recommended to culturing material taken from the conjunctival sac, to identify the sensitivity of bacteria to ofloxacin .
With long-term use may develop bacterial resistance and the emergence of non-susceptible to malaria infections. If symptoms of stress or clinical improvement is no need to stop treatment and start Floksalom alternative therapy.
During treatment prohibited from using hard contact lenses. Therefore it is necessary to remove such lenses before applying the drug and put them 20 minutes after instillation.
Analogs Floksala
Vigamoks
Known analogs of eye drops Floksal: Vigamoks . Unifloks .
Babies
The drug is resolved to use for children and infants.
During pregnancy and lactation
No information about the negative effects of the drug on the fetus, but, despite this, it may not be used in pregnant and lactating women.
Reviews Floksale
Reviews ointment Floksal not report the occurrence of side effects. As an ointment, eye drops are highly effective when used according to indications - evidenced by the numerous reports of patients. Lack of medical action after taking the drug is rare.
Price Floksala
Cost eye drops Floksal in Russia is 177-222 rubles, eye ointment It will cost 225-297 rubles.
In Ukraine, the average price drops - 68 hryvnia, and the price ointment Floksal It is hovering around 69-73 hryvnia.
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