Eufillin

Description overdue on 02/10/2013

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Bronchodilator. Active component - aminophylline. The mechanism of action of the drug is aimed at blocking purine (adenosine) receptors increase cAMP accumulation in the tissues, the inhibition of phosphodiesterase, reducing the contractility of the smooth muscle, decrease in revenues through the channels of the cell membrane calcium ion. The main ingredient is a derivative of purine. The drug increases renal blood flow , Renders vazodilatirtee peripheral the impact of, renders a moderately expressed diuretic effect , Relaxes the smooth muscle of blood vessels (mainly kidneys, skin, brain), bronchi.

Under the influence of the drug reduced the rate of release of mediators of allergic reactions to stabilize the membrane of fat cells, stimulates the respiratory center, improving the operation of the intercostal muscles and respiratory muscles, stimulates contraction of the diaphragm It increases mucociliary clearance. Electrophoresis aminophylline has vasodilatory, anti-inflammatory, resolving and analgesic effects. The medicament reduces the level of carbon dioxide in the blood, and its oxygen saturation, respiratory function by normalizing.

With hypokalemia   medication enhances ventilation. Eufillin tissue increases the need myocardial oxygen increases   coronary blood flow Increases heart rate and heart rate, stimulates the functioning of the heart, lowers the tone of the blood vessels, lowers blood pressure in the pulmonary circulation, reduces pulmonary vascular resistance, inhibits platelet aggregation rate, expanding the lumen of the bile duct, normalizes microcirculation It improves blood rheology, reduce thrombosis, increases resistance to deformation of erythrocytes. Aminophylline produced in tablet dosage form, capsules, suppositories, solution.

Indications:

Drug Usage Eufillin recommends prescribers at broncho-obstructive syndrome : COPD ( emphysema , Chronic obstructive bronchitis), asthma; at Sleep apnea , Edema syndrome on the background of renal pathology system in "pulmonary" heart, pulmonary hypertension . Indications for parenteral administration Eufillin: left ventricular failure with respiratory failure by type of Cheyne-Stokes and bronchospasm, disorders of cerebral circulation on ischemic type, apnea in newborns, asthmatic status .

Contraindications:

Eufillin not prescribed for epilepsy, intolerance to theophylline, ulcers of the digestive tract and in severe hypertension or hypotension, gastritis with high acidity, hemorrhagic stroke, heavy tachyarrhythmias , With hemorrhages in the retina of the eye. Eufillin children up to 3 years is not appointed. During pregnancy, prolonged hyperthermia, severe coronary insufficiency, with increased convulsive readiness, chronic heart failure , Frequent ventricular arrhythmia, disseminated atherosclerosis, angina pectoris, acute myocardial infarction, uncontrolled hypothyroidism , Recent bleeding from the digestive system, breastfeeding, prostatic hypertrophy, thyrotoxicosis, gastroesophageal reflux Eufillin used with caution. Rectal form of the drug is not indicated for diseases of the colon and diarrhea.

Side effect:

Nervous system:   limb tremor, agitation, dizziness, anxiety, insomnia , Headaches, irritability. Cardiovascular system:   increased frequency of angina attacks, cardialgia , Drop in blood pressure, arrhythmia, tachycardia, palpitations. The digestive tract:   diarrhea, exacerbation of peptic ulcer disease, gastroesophageal reflux disease , Nausea, gastralgia, heartburn , Violation of appetite, vomiting. Perhaps the formation allergic Answer in the form fever, itching, skin rash . The treatment may increase urine output, feeling the tides-to-face, tachypnea , Chest pain, hematuria, albuminuria , Increased sweating, hypoglycemia. By reducing the dosage of the drug observed decrease in the severity of side effects.

Overdose:

Manifested by diarrhea, stomachalgia , Anorexia, tachypnea, motor excitation, cramps, photophobia, anxiety, tremor of the extremities, tachycardia , Flushing of the skin face, gastrointestinal bleeding, vomiting, nausea, ventricular arrhythmias, insomnia . In severe poisoning are recorded epileptic seizures , Drop in blood pressure, hypokalemia, hyperglycemia , Sputannosti of consciousness, necrosis muscle tissue, hypoxia, renal failure with myoglobinuria, metabolic acidosis .

Requires gastric lavage and bowel combination of polyethylene glycol and electrolytes, appointment enterosorbents, symptomatic therapy, hemodialysis, plasma sorption, hemosorption, forced diuresis . With the development of seizures carried out oxygen therapy Provide an open airway. For relief of an attack intravenous 0, 1-0, 3 mg / kg of diazepam. If severe vomiting and nausea administered ondansetron and metoclopramide.

Mode of application:

Average dose - 300 mg twice daily. Eufillin drug treatment is initiated with smaller dosages, gradually increasing the amount of drug to achieve the desired therapeutic effect. Dose picked individually depending on the age group of the patient's weight, the nature and course of the disease pulmonary system, comorbidity. Maintenance dose for adults weighing 60 kg is 600 mg / day; less than 60 kg - 400 mg / day.

When liver disease and diseases of the cardiovascular system prescribed daily dosage of the drug Eufillin - 400 mg. Elderly patients with heart disease, liver and concomitant viral infection reduced the daily dose of medicament. For patients with reduced clearance of theophylline prescribed initial dose - 250 mg per day, 2 days the amount of drug increased to 500 mg per 1 reception. Eufillin ampoules is administered intravenously saline.

Special instructions:

Tablets retard not apply for emergency relief emergency conditions. We recommend caution when taking caffeine drinks and food in large quantities during the treatment. With good control of bronchial asthma and in the absence of pronounced side effects, correction mode 1 is performed every 6-12 months. Therapy prolonged forms of the drug is carried out under mandatory supervision in the blood levels of theophylline. Eufillin at pregnancy applies only under vital indications.

Drug Interactions:

The absorption of the drug decreases as the reception enterosorbents   and antidiarrheal agents. The probability of side effects increases with concurrent therapy glucocorticosteroids , ISS (developing hypernatremia ), Drugs that stimulate the central nervous system, drugs for general anesthesia (developing ventricular arrhythmias).

Moratsizin, estrogensoderzhaschie oral contraceptives, aminoglutethimide, carbamazepine, phenytoin, rifampin, sulfinpyrazone, isoniazid, phenobarbital are inducers of microsomal oxidation and can improve the clearance of theophylline, which may result in the need to increase the dose. Simultaneous therapy inhibitors of cytochrome P450 (disulfiram, enoxacin, cimetidine, allopurinol,   linkomitsin Macrolides, mexiletine, verapamil, ticlopidine, thiabendazole, propafenone, methotrexate, recombinant interferon alpha, isoprenaline, fluoroquinolone) enhanced efficacy of theophylline, which necessarily require dose reduction.

Eufillin reduces efficiency beta-blockers , Drugs lithium, the opposite effect is observed in the treatment of diuretic drugs, and beta-agonists. The drug is not used in conjunction with other xanthine derivatives. The drug is compatible with antispasmodics. If necessary, use anticoagulants   the drug is prescribed with caution.