Utrozhestan

Description overdue on 17.05.2012

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The hormone of the corpus luteum, progestogen. The active substance is progesterone. The principle impact of the drug based on the binding of the base material with progesterone receptors which are located on the target organs, following penetration into the nucleus and activate DNA, RNA stimulation. Utrozhestan in secretory phase facilitates the transition of the mucosal wall of the uterus proliferation (under the influence of the follicular hormone). After the onset of fertilization drug facilitates the transition of the mucous wall of the uterus in a state that is required for the development of the egg. Utrozhestan reduces the severity of muscle contractility and excitability of the fallopian tubes, uterine wall, the drug stimulates the formation of terminal elements in the mammary glands. The drug increases the concentration of basal and stimulated insulin Increases glucose utilization increases fat reserves proteinlipazu stimulates, increases the production of aldosterone promotes accumulation of glycogen in the liver system. In large doses suppresses the production of pituitary Utrozhestan gonadotropins , And in small doses, on the contrary, it accelerates. The drug increases the excretion of nitrogen with urination, reduces the severity of azotemia, induces lactation, activates the process of growth of secretory acini department in the mammary glands. Utrozhestan available in capsule form.

Indications:

Utrozhestan prescribed for fibrocystic mastopathy , Premenstrual syndrome, during Menopause   as the progestogen component in combined hormone replacement therapy with estrogen. When nonfunctioning ovaries, complete lack of progesterone at   postmenopausal , Menopause, premature menopause, endometriosis, for the prevention of uterine fibroids, endocrine infertility, miscarriage threat Utrozhestan administered vaginally.

Contraindications:

Utrozhestan not appoint a tendency to   thrombosis , Hepatic pathology system, acute forms thromboembolic disorders , Phlebitis, with porphyria, incomplete abortion, bleeding from the reproductive system of unknown origin. With   diabetes , Hyperlipoproteinemia, depression, chronic renal failure, hypertension, diseases of the cardiovascular system, breastfeeding, migraine drug prescribed after consulting experts. Utrozhestan pregnancy used with caution.

Side effect:

Reduction of the menstrual cycle, drowsiness, allergic reactions, intermenstrual bleeding, transient dizziness.

Mode of application:

Utrozhestan take before going to bed in the evening. With dysmenorrhea , Premenstrual syndrome, pre-menopausal women, fibrocystic breast Utrozhestan take 10 days to 200-300 mg 17 to 26 days of the cycle .  When menopause when hormone replacement therapy in patients receiving estrogens take 200 mg a day for 10-12 days .  When egg donation progesterone intravaginal use of estrogen therapy on the background 13 and 14 days of the cycle, 100 mg / day, then twice a day at 100 mg .  To maintain the luteal phase during IVF drug prescribed from the day of hCG injection of 400-600 mg per day up to 12 weeks of pregnancy .  When infertility caused by disorders of the corpus luteum, in induced or spontaneous menstrual cycle to maintain the luteal phase of the preparation is applied to the 17 day cycle at 200-300 mg daily for 10 days .  Utrozhestan during pregnancy, menstruation delay prescribed by the standard scheme .  For the prevention of and the threat of an abortion drug is administered before 12 weeks of pregnancy, twice a day for 100-200 mg .

Special instructions:

Utrozhestan does not apply to Contraception . Because of the risk of liver disease is recommended to be careful in appointing a drug in the 2, 3 trimester. The drug affects the concentration, driving a vehicle.

Drug Interactions:

Utrozhestan reduces the effectiveness of prolactin Oxytocin .