Lasix

Description overdue on 14.12.2011

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The active ingredient of the drug Lasix   It is Furosemide . It has a diuretic action of producing reuptake blockade of sodium ion and chlorine loop of Henle   (in its rising part). Lasix also significantly affects the convoluted tubules. It accelerates the excretion of magnesium, potassium, calcium. When administered by intravenous Lasix rapidly decreases blood pressure, pulmonary artery pressure and the left ventricle. Within five minutes after injection into a vein can be seen diuretic effects, the maximum effects of drugs observed in thirty minutes. The diuretic period lasts about two hours. For internal use of its diuretic effect of the drug begins within the first hour, and two hours later it reached the maximum level. The effect after receiving the last about seven hours. Lasix excreted in the urine as the compound with glucuronic acid .

Indications and methods of use of the drug:

Lasix drug prescribed to patients who are diagnosed edematous syndrome That evolved as a result of the following diseases: heart disease, kidney, liver, acute left ventricular failure, burn disease, preeclampsia pregnant women (in this case, Lasix is ​​used only after the restoration of the BCC). The drug is also used in the process of forced diuresis   and during the complex therapy of hypertension.

The dosage and method of use of the drugs administered individually. The dose is adjusted depending on the severity of disease and the amount of urine output. Typically, the drug is taken in tablets, but urgent cases, it is administered by intravenous bolus, during 1.5-2 minutes.

If edema syndrome have an average degree of severity, the drug is prescribed in a dose of 20-80 mg (oral) or 20-40 mg (reception intramuscularly or intravenously). If the sufficient effect is not observed, the dose is increased by 40 mg (oral) or 20 mg (injection). The dose is adjusted until adequate urine output. The greatest effect of the drug is observed in the case where it is assigned 2-4 times a week.

Before the drug dose is calculated children given the child's weight and method of administration. If conducted oral, the starting dose is 2 mg / kg if receiving an injection, it is administered 1 mg / kg. Further the dose can be increased to 2 mg / kg (oral) and 1 mg / kg (injection).

In the treatment of hypertension using 80 mg of the drug knocks. This dose should be divided into two steps. If the effect of the treatment is not observed, then there is no need to increase the dose. It is parallel to taking other antihypertensive agents.

In the case of pulmonary edema 40 mg of Lasix administered intravenously. If there is no effect, after 20 minutes, introduced another 20-40 mg. When forced diuresis, 20-40 mg of Lasix is ​​added to the solution for infusion. Further, the dose may be adjusted.

Contraindications and side effects:

Do not take Lasix at electrolyte imbalance, severe intolerance to furosemide or other components of the drug, with the anurii . dehydration . deficit bcc . hepatic coma . Also, the drug is not administered during the first trimester of pregnancy and during breastfeeding.

As side effects can be observed decrease in blood volume (for large doses of drug), therefore, can manifest hemoconcentration and thrombosis . Often when taking Lasix develop water-electrolyte disturbances: alkalosis , Lack of chlorine, sodium, calcium, potassium, as well as violation of the biochemical characteristics of the blood.

May develop allergic reactions: skin manifestations, in some cases - anaphylactic shock . Rarely can occur leukopenia . thrombocytopenia , Hemolytic changes eosinophilia . agranulocytosis . When pregnancy (second and third trimester) Lasix can be used only in case of strict indications.

Specific recommendations:

Lvaziks may enhance the effects of cardiac glycosides . Could improve antibiotics   blood while taking Lasix and cephalosporin antibiotics or aminoglycosides . In parallel reception ACEI   Lasix and can significantly increase the hypotensive effect leading to collapse and reduce the development of kidney function.

In parallel consumption of alcohol can reduce the concentration of attention and speed of reaction. In case of overdose there may be a manifestation hypotension , Electrolyte imbalance, dry mouth, dizziness, vision problems. Store this medication Lasix must be in a dark place, with temperature control should be between 17 to 26 ° C.