Description overdue on 01.07.2014
- Latin name: Artrozan
- ATC code: M01AC06
- Active substance: Meloxicam (Meloxicam)
- Manufacturer: Of Farmstandart- Ufavita, Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Artrozana (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
The tablets contain the active ingredient Artrozan meloxicam 7 + 5 mg Excipients ( colloidal silicon dioxide, lactose monohydrate, sodium citrate, potato starch, povidone, magnesium stearate ).
In the 1 ml solution for intramuscular administration is 6 mg meloxicam and additional substances ( glycine, sodium chloride Water , Poloxamer, glycofurol, pp One molar sodium hydroxide ).
Product form
The drug is released in the form:
- tablets various shades of yellow, with chamfers, risks, flat shape, in packs of 10, 15, 20, 30, 40, 45, 50, 60, 75 and 100 pieces;
- solution for intramuscular administration Transparent, yellow-green, 5 ml ampoules to 3, 5 and 10 pieces in a package.
Pharmacological action
Analgesic, anti-inflammatory, antipyretic.
Pharmacodynamics and pharmacokinetics
Active substance meloxicam - Derivative oxicam . It has anti-inflammatory effects by blocking the synthesis of prostglantinov and the enzyme tsikooksigenazu-2 Which takes part in the cycle arachidonic acid .
Under the action of meloxicam Activity mediators of inflammation and permeability vascular walls significantly reduced the inhibition of reactions of free radicals . Analgesia is due to reduced activity and interaction prostglantinov nerve .
Sustained maximum concentration is reached within three -Five days. Good binds to proteins in the blood plasma (99% and higher). Metabolised in the liver, forming four metabolite. They do not play role in pharmacodynamic processes. The metabolites are excreted in the feces and urine for a period of from 15 to 20 hours.
Indications
The medicine appoint at various inflammations of the joints, which are accompanied by pain syndrome:
- osteoarthritis ;
- osteochondrosis ;
- myositis ;
- rheumatoid arthritis ;
- sciatica;
- ankylosing spondylitis .
Contraindications
- drug allergy or a special sensitivity to the drug, including group NSAIDs ;
- stomach ulcers and 12-finger intestine ;
- bronchial asthma;
- Polyps nose and nasal cavity;
- bleeding and (or) hemorrhage in the stomach, intestines, etc .;
- severe heart, kidney and liver failure;
- age up to 15 years;
- hemophilia;
- hyperkalemia ;
- pregnancy and lactation.
Side effects
You may experience:
- indigestion . burp . gastric bleeding and stomach ulcers;
- hepatitis , Improving the level and activity liver enzymes . Acute renal failure ;
- bronchospasm . angioedema . peripheral edema ;
- leukopenia, thrombocytopenia, anemia ;
- tachycardia, anaphylaxis ;
- esophagitis, allergic skin reactions, photosensitivity and pruritus ;
- headache, sleepiness . dizziness . disorientation and blurred vision ;
- stomatitis, conjunctivitis and hives .
Instructions for use Artrozana (method and dosage)
Tablets are taken once daily, with food, drinking water. The recommended daily dose is from 7, 5 mg to 15 mg, depending on the intensity and pain of the disease.
If the drug can not be taken orally May designate Intramuscular injection .
Injections Artrozana, instructions for use
Injections Artrozana prescribed for acute pain during the first few days of illness. Injections of the drug produce intramuscularly Deep in the tissue. The daily dose is 7. 5 to 15 mg, and therapy is started with a low dose and is increased to achieve the desired effect.
You should not exceed the recommended dose might increase the risk of side effects.
Overdose
Symptoms of overdose are
- indigestion ;
- pain epigastric , Possible bleeding in the stomach ;
- impairment of consciousness;
- vomiting and nausea;
- asystole ;
- stop breathing;
- abnormalities in the kidneys and liver.
Therapy - gastric lavage, chelators Symptomatic.
Cooperation
With the combination of:
- lowers blood pressure with drugs that reduce their effectiveness;
- from diuretics and tsiklosprorinom Significantly increases the risk of kidney failure;
- from vitamin K antagonists . fibrinolytics . heparin serotonin reuptake inhibitors - There may be bleeding.
With combined with caution intrauterine . lithium preparations . kolestiraminom , Other NSAIDs . Methotrexate .
Terms of sale
Requires a prescription.
Storage conditions
Avoid drug interactions with water, in direct sunlight, store at temperatures above 25 degrees. Keep out of the reach of children.
Shelf life
In tablets - 2 years, at a solution for injection - 5 years.
Cautions
Using drugs can mask infections that occur in the body.
When you use more than 14 days, the control should be made in the liver and kidneys.
If the patient there is a predisposition to the emergence of stomach ulcers and 12-duodenal ulcer, to use a Artrozan worth with extreme caution.
When an effects associated with reduced rate psychomotor reactions , Operate machinery and driving vehicles to be on time to stop.
Analogs Artrozana
Lornoxicam
Teksamen
Amelotex
Movalis
Meloxicam
Ksefokam
Revmoksikam
Artrozana analogues are: meloxicam, Matara, Melbek, medsikam, movalis, bi-Xico, Lem, M-QAM, movasin, mesipol, mirloks, Amelotex, Melox, Melox, meloflam, moviks .
Reviews Artrozane
Reviews injections Artrozana good. The drug is relatively cheap and quite effective. Many people helped to cope with the pain in various diseases of the joints. Pills, has the same effect as the injections. Of the minuses marked side effects such as headaches, stomach aches and dizziness, but it happens infrequently.
Price Artrozana where to buy
Cost tablets Artrozan 15 mg, 225 rubles per 20 pieces.
Cost injections Artrozan is about 219 rubles in 3 ampules of 2, 5 ml.
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