Timolol

Description overdue on 06.02.2012

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Remedy for glaucoma . The drug indiscriminately blocking beta-adrenergic receptors. Timolol is applied topically. Drug action is aimed at reducing the intraocular pressure by reducing the amount of aqueous humor formed by partially increasing its outflow. Timolol no effect on pupil diameter, accommodation of , Does not impair visual acuity does not affect the quality of night and color vision. The drug action starts in twenty minutes. Timolol is produced in the form of drops, a gel.

Indications:

Timolol is prescribed for secondary glaucoma , Open-form of glaucoma, angle-closure glaucoma , Congenital form of glaucoma, ocular hypertension , Acute elevated intraocular pressure.

Contraindications:

Timolol is contraindicated in corneal degenerative lesions, hypersensitive to the components. In bronchial asthma, COPD, breastfed atriventrikulyarnoy blockade, hypotension, pulmonary disease, pregnancy, atrophic rhinitis , Diabetes mellitus, in the neonatal period, severe cerebrovascular insufficiency administered with caution.

Side effect:

Lacrimation, conjunctival irritation, photophobia, itching, conjunctival hyperemia . keratitis , Blepharitis, edema of the corneal epithelium, punctate keratopathy Ptosis, diplopia. Among systemic reactions may be noted bradycardia, collapse, drop in blood pressure, rhinitis, paraesthesia, epistaxis, nasal congestion, sleepiness, dizziness, myasthenia gravis, depression, hallucinations , Diarrhea, vomiting, nausea, ringing in the ears, allergic.

Overdose:

Develop obscherezorbtivnye effects characteristic of many beta-blockers: bronchospasm , Bradycardia, headache, dizziness, vomiting, arrhythmia. Recommended timely rinsing solution of sodium chloride, water. Further treatment posimptomnoe.

Mode of application:

Timolol instilled twice daily, every conjunctival sac of one drop (solution 0, 25%). If necessary, concentration of the solution was raised to 0, 5%. After normalization and stabilization of intraocular pressure switching to maintenance therapy: once a day, one drop (solution of 0, 25%).

Special instructions:

Recommended to avoid activities that require good vision in the dark. Care must be taken in the management of transport in the dark. Monitoring the effectiveness of the treatment is carried out in three weeks. Long-term therapy may lead to a weakening of the drug timolol. The treatment requires regular monitoring of slezovydeleniem , Assessing the integrity of the cornea. It is recommended to evaluate the value of a stable visual field. Once a month, the intraocular pressure was measured. Preservative medicament deposited on contact lenses.

Drug Interactions:

Beta-blockers are systemic action, pilocarpine, epinephrine   enhance the effectiveness of the drug timolol. It is unacceptable simultaneous application neuroleptics   (antipsychotics) tranquilizers   (anxiolytics). Timolol improves general anesthetics, muscle relaxants. It is recommended to give up the intravenous diltiazem . verapamil   in view of the high probability of falling blood pressure, of bradycardia, AV-conduction oppression. Invalid receive alcoholic beverages. Be wary appointed to insulin , Beta-blockers, corticosteroids.