Heparin

Description overdue on 26.11.2011

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The preparation heparin   - this anticoagulant A means which stops the blood clotting. Heparin enabled on composition antisvertyvayushey system together with fibrinolizinom . HP also provides a lock biosynthesis It affects the state Platelet , Reducing their aggregation. Also, heparin suspends Activity hyaluronidase It has a positive effect on coronary blood flow . After administration of heparin reduces the number of cholesterol   in serum, as well as enlightening effect on lipaemic plasma . Please note that as a gipoholesterinemichskoe means the drug is not used because of the risk of bleeding . There is evidence that heparin has immunosuppressive properties. Therefore, it is used in a number of autoimmune diseases To prevent rejection after Kidney Transplantation . Protivosvertyvayushee drug effect occur following intravenous, subcutaneous and intramuscular administration.

Action the drug manifests itself quickly, but it is a short. If you enter a single intravenous heparin, the anti-clotting manifest almost immediately after its introduction and will last about five hours. After intramuscular administration of the drug begins to act 15-30 minutes later, the effect lasts up to 6 hours. With the introduction of the drug under the skin of the impact appears after about 60 minutes and lasts up to 12 hours. Constant effect can be obtained when administered intravenously, however, in order to prevent the drug is administered subcutaneously and intramuscularly.

Indications and methods of use of the drug:

Heparin is widely used as a therapeutic and preventive agent for various kinds clotting disease , And also complications such diseases. For example, it is used to control and prevent the formation of blood clots   in acute myocardial infarction In case of thrombosis and embolism   main veins and arteries, eyes, receptacles in the brain. Also, the drug is prescribed for carrying out operations on blood vessels and the heart, in order to maintain blood in a fluid state devices which are used for cardiopulmonary bypass and devices for Hemodialysis .

The drug is given taking into account the individual characteristics of each case. In the case of acute myocardial infarction 15 000-20 000 units of heparin injected into a vein in first aid. After hospitalization he heparin administered intramuscularly at a dose of 40 000 IU per day even at least six days reception means occurs every four hours in equal doses. For 1-2 days before the abolition of the means to gradually reduce the dose to 5000-2500 units during each injection.

Heparin administered also and by infusions. In patients with pulmonary arterial thrombosis massive infusion administered dose in this case is 40 000-60 000 units, then the drug is administered intramuscularly, already, the dose is 40 000 IU per day. In the case of peripheral venous thrombosis and heparin is first administered at a dose of 20 000-30 000 units intravenously, then the dose per day is 60 000-80 000 units. In each of the cases, several days before the withdrawal of the drug, patients should receive indirect anticoagulants. After complete discontinuation of heparin reception continues. As a prophylactic agent at risk of thromboembolism, heparin is administered subcutaneously 5000 units 1-2 times a day before operation and after it.
In the case of a direct blood transfusion heparin injected into a vein to the donor, the dose is 7 500-10 000 IU. Clotting time is determined in the first seven days of therapy, but not less than once in two days. If the drug is administered fractional, the blood samples were taken prior to each injection of heparin.

Contraindications and possible side effects:

You can not take heparin in patients with bleeding diathesis As well as other diseases that are accompanied by too slow coagulation. Also, heparin is contraindicated in patients with high vascular permeability, bleeding of any location (except in the case of bleeding embolic pulmonary infarction   or kidney ) bacterial endocarditis   either inflammation of internal cavities in heart. The drug is banned for use in severe disturbances in the functioning of the liver, kidneys, with lejkozah . anemias   of different types, as well as cardiac aneurysm . gangrene   venous type.

In the application of the tool should always take into account the likelihood of bleeding. To prevent possible complications, heparin must be taken solely in stationary conditions. With the threat of hypocoagulation   dose of the drug is reduced.

Should discontinue therapy if there are a variety of allergies or intolerance to the drug appears.

Specific recommendations:

Heparin should be stored in a dark place at a low temperature.