Vigamoks

Description overdue on 10/11/2014

• Latin name: Vigamox
• ATC code: S01AE07
• Active substance: Moxifloxacin (Moxifloxacin)
• Manufacturer: Alcon Pharmaceuticals, Russia

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Eye drops Vigamoks, instructions (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• During pregnancy (and lactation)
• Analogs
• Reviews
• Price, where to buy

Composition

Eye drops Vigamoks contain 5 to 45 mg moxifloxacin hydrochloride   + Adjuvants ( boric acid, water, sodium chloride, concentrated hydrochloric acid ).

Product form

Vigamox   produced in the form of colorless transparent droplets into vials of 5 ml or 3, in cardboard packs of one vial.

Pharmacological action

Antibacterial For topical use.

Pharmacodynamics and pharmacokinetics

The active ingredient of the drug - fluoroquinolone   fourth generation antibiotic Which inhibits the activity DNA gyrase   and topoisomerase 4 . In this way, Replication   and DNA recombination   bacteria, updated and reproduction become impossible.

Due to a mutation Gram negative bacteria   they may have resistance to this type of antibiotic. The probability of occurrence cross-resistance   from beta-lactams . aminoglycosides   and   macrolides   is extremely small.

Moxifloxacin   active against:

• Gram-positive   bacteria ( Staphylococcus aureus, Streptococcus pyogenes group A, Streptococcus pneumoniae );
• Gram   ( Haemophilus influenzae, Escherichia coli, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Enterobacter cloacae );
• other types of atypical bacteria ( Chlamydia spp., Mycoplasma pneumoniae, Mycoplasma spp., Chlamydia pneumoniae ).

In conducting research in laboratories, moxifloxacin   showed activity against Streptococcus milleri, Staphylococcus saprophyticus, Streptococcus mitior, Staphylococcus epidermidis, Staphylococcus hominis, Providencia rettgeri, Enterobacter aerogenes, Enterobacter sakazaki, Enterobacter Intermedius, Morganella morganii, Str. agalactiae, Streptococcus dysgalactiae, Staphylococcus saprophyticus, St. haemolyticus, Enterobacter agglomerans, Proteus mirabilis, Proteus vulgaris, Providencia stuartii .

This group can be attributed anaerobes : Propionibacterium spp., Bacteroides distasonis, Porphyromonas magnus, Bacteroides ovatus, Bacteroides thetaiotaornicron, Clostridium perfringens, Prevotella spp., Bacteroides fragilis, Bacteroides eggerthii, Bacteroides uniformis, Porphyromonas anaerobius, Porphyromonas asaccharolyticus .

Also in vivo   antibiotic inhibits the ability to live Gram   Microorganisms: Enterobacter agglomerans, Klebsiella oxytoca, Bordetella pertussis, Enterobacter Intermedius, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Enterobacter aerogenes, Proteus mirabilis, Enterobacter sakazaki, Morganella morgana, Porphyromonas spp., Fusobacterium spp .

In the treatment of diseases caused by the above pathogens, efficacy of the product has not been proved. This group also includes Caxiella burnettii   and Legionella pneumophila .

Drops for eyes with moxifloxacin does not show phototoxic   or fotogenotoksichnyh   properties, unlike other means   quinolone series .

For topical use the drug is absorbed into the systemic circulation in minor degree is 1000 times less than when given orally. The half-life of plasma is 13 hours.

Indications

The drug is indicated for the topical treatment conjunctivitis   and other inflammatory diseases of the eye caused by a number of bacteria that are sensitive to the effects of the antibiotic.

Contraindications

The drug is not recommended for use:

• nursing women;
• for children aged up to one year;
• at allergies   on any of the components, in particular moxifloxacin .

Side effects

Adverse reactions that occur when using tools, divided into local and systemic.

Local effects in order of frequency of appearance:

• pain and irritation of the mucous eye;
• bloodshot eyes   or conjunctival dryness;
• swelling, punctate keratitis , Blurred vision, erythema century Local hemorrhage ( subconjunctival );
• erosion , Haze and defects corneal ;
• the occurrence of deposits on the cornea, uncharacteristic discharge from the eyes, endophthalmitis Sensitivity to light, blepharitis , An increase in pressure (intraocular).

Systemic adverse reactions:

• taste disorder, a metallic or sour taste in the mouth, burning sensation;
• paresthesia . headache , Discomfort in the nose, lump in the throat, nausea and vomiting, decreased hemoglobin ;
• heart palpitations, shortness of breath, rash, and itching of the skin . allergic reactions .

Very rare opportunity: anaphylactic shock, collapse, angioedema , Fainting.

If you have the above reactions it is necessary to inform the doctor, if there is an allergy - stop taking the money.

Eye drops Vigamoks, instructions (method and dosage)

Only local ophthalmological   use.

According to the instructions for use Vigamoksa, administered one drop into the affected eye up to 3 times a day. Typically, the patient's condition improved after five days of treatment means, but should continue treatment for another 2-3 days.

If within 5 days of taking the drug no improvement, then you should consult with a specialist.
For children older than one year, patients with kidney failure and liver diseases, dosage adjustment is not required.

Overdose

No cases of overdose were reported. If an excess amount of the drug has got into eyes, it can be rinsed with lukewarm water.

Cooperation

The interaction of the formulation with other drugs has not been studied.

However, according to the interaction of an antibiotic other forms of manufacture, it can be combined with warfarin, Probenecid, theophylline, digoxin, glibenclamide, rinitidinom, contraceptives (oral) , Medicines which are involved in the metabolism enzyme P450 .

With combined with caution cisapride, neuroleptics, erythromycin, quinidine, sotalol, procainamide .

Terms of sale

We need a recipe.

Storage conditions

Keep away from children, temperature of 2 to 25 degrees.

Shelf life

2 years.

After the first use of its drug shelf life is reduced to one month.

Cautions

With prolonged use of the drug may cause other infections, such as fungi.

In order not to contaminate the applicator, it is not necessary to touch the tip of the bottle to a variety of surfaces. After each use, the bottle should be tightly closed.

Due to the possible violation of visual acuity, clouding of the eyes, it is not recommended to drive vehicles and operate machinery while taking the drug.

During pregnancy and lactation

The drug is not recommended during pregnancy and breastfeeding.

Analogs Vigamoksa

Match code ATC 4th level:

• Floksal

Analogues: ointment and drops Floksal . Mofloks . Avelox . Moxifloxacin . Tevaloks .

Reviews Vigamokse

The drug is prescribed for conjunctivitis and barley, especially in children. According to the reviews of the eye drops Vigamoks, they are sufficiently effective help quickly and surely. However, many people confuse a large number of side effects, most often allergic. Some people prefer cheaper counterparts.

Price Vigamoksa

Price eyedrops Vigamoks is about 205 rubles per bottle 5 ml.

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