Losek MAPS

Description overdue on 11/30/2014

• Latin name: Losec Mups
• ATC code: A02BC01
• Active substance: Omeprazole (Omeprazolum)
• Manufacturer: AstraZeneca (Sweden)

Photos of the drug

Tweet

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Losek CI (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

In addition omeprazole   CI Losek tablets contain MCC, hydroxypropylcellulose, magnesium stearate, sugar granules, polyethyleneglycol, crosslinked polyvinylpyrrolidone, talc, iron oxide, glyceryl monostearate, hydroxypropyl methylcellulose, methacrylic acid copolymer, paraffin, polysorbate, sodium stearyl fumarate, triethyl citrate, titanium dioxide.

Product form

The drug is sold in the form of tablets which are coated.

Pharmacological action

The drug reduces the gastric acid secretion . This is a special proton pump inhibitor .

Pharmacodynamics and pharmacokinetics

The drug is antiulcer   agent. It inhibits the action H + -K + -ATPase   in gastric parietal cells . Thus, the final stage is blocked formation of hydrochloric acid. The action of the drug depends on the dose. It effectively inhibits basal   and stimulated secretion   with daily use.

The drug reaches maximum efficiency within 4 days. Its effect in combination with antibacterial   means calls Helicobacter pylori eradication . In this cropped manifestations of the disease achieved remission, healing damage to the gastric mucosa, the risk of bleeding from the gastrointestinal tract. In applying Loseka CI is no need for a long anti-ulcer therapy.

Tablets are absorbed in the small intestine. Absorption completed in 3-6 hours after eating. If readmission funds bioavailability It increased to 60%. Food intake has no influence on it. Relationship to plasma proteins - about 95%.

Half-life plasma   - Less than an hour. The active substance of the drug is completely split system cytochromes   primarily in the liver. 80% of the drug is excreted as metabolites   urine, and another 20% - faeces.

Indications

The medicine is indicated for:

• of acid indigestion ;
• stomach ulcer Induced Helicobacter pylori ;
• Zollinger-Ellison syndrome ;
• gastric ulcer and duodenal ulcer   (including, if the disease is caused by NSAIDs );
• gastroesophageal reflux .

Contraindications

Do not use this tool if you are allergic to its components.

Side effects

Typically, the drug is well tolerated by patients. Undesirable side effects usually are mild and pass quickly. Among them are noted:

• skin - rash, itch , Photosensitivity, alopecia . erythema multiforme ;
• CNS - drowsiness . headache . vertigo . dizziness . paresthesia . insomnia . confusion . depression , Agitation, hallucinations ;
• liver - liver dysfunction, increased enzymes   liver encephalopathy   (liver disease with complications) hepatitis ;
• circulatory system - leukopenia . agranulocytosis . thrombocytopenia . pancytopenia ;
• musculoskeletal system - muscular weakness , Pain in joints and muscles;
• GIT - diarrhea , Pain in the abdomen, vomiting, constipation , Nausea, flatulence , Dry mouth, candidiasis . stomatitis ;
• endocrine system - gynecomastia ;
• Other - hives . fever . interstitial nephritis . angioedema . bronchospasm . anaphylactic shock And strong Sweating , Blurred vision, decrease in the level of sodium in the blood, peripheral edema , Taste disturbance, malaise .

Instructions for use Losek CI (method and dosage)

Instructions for use tablets Losek CI (not Losek Max, as many believe) says that they are intended for oral   use. Swallow whole without chewing. It is advisable to drink liquids. Furthermore, the tablets can be dissolved in water or fruit juice. Such a solution should be drunk within half an hour after preparation.

Instructions for use Losek ITA reports that the exact scheme of drug use depends on the disease:

• peptic ulcer   in the acute phase - the patient should take 20 mg of the drug every day. The course lasts for 2 weeks. If the total scarring did not come, we can still carry out repeated therapy 2 weeks;
• the need to prevent deterioration duodenal ulcer   - The patient should take 10 mg of the drug every day. If necessary, the dosage was increased to 20-40 mg;
• gastric ulcer . resistant   to therapy - 40 mg of the drug per day. Recovery is usually within eight weeks;
• erosive and ulcerative lesions   in the gastrointestinal tract (gastroduodenal Division) in HIV-infected patients - 20 mg applied once a day. Compatible with the treatment of HIV infection. The course of the average for 4 weeks. If a full recovery has not come, you can repeat the treatment;
• gastric ulcer Provoked Helicobacter pylori   - Perhaps three different treatment regimens. 1) 20 mg Losek CI, 500 mg Clarithromycin   1 g Amoxicillin . 2) 20 mg Losek CI, 250 mg Clarithromycin   and 500 mg Tinidazole   (or 400 mg Metronidazole ). All medicines should be eaten within a week 2 times daily. 3) Throughout the week, take 20 mg every day Losek CI 1 times 400 mg Metronidazole   3 times 500 mg Amoxicillin   3 times. In addition, the doctor may prescribe a "dual therapy". In this case Losek CI drink daily dosage of 40-80 mg and the Amoxicillin   - 1, 5 g (dose is divided into parts). The course lasts for two weeks. After Helicobacter pylori eradication   subsequent therapy is conducted in the usual way, as in duodenal ulcer and stomach . If the end of the course test for Helicobacter pylori   is positive, the treatment can be repeated;
• duodenal ulcer . resistant to therapy - 40 mg of the drug daily. Healing occurs in most cases during the months;
• gastric ulcer   exacerbation - you need to take 20 mg of the drug per day. Therapies designed to 4 weeks. Unless ulcer   upon completion of the course is not fully healed, the treatment can be repeated;
• the need for prevention of exacerbations stomach ulcers   - Should take 20 mg of the drug per day. If necessary, the daily dose is increased to 40 mg;
• the need for prevention of exacerbations ulcers of the stomach and duodenum , Appearance dyspeptic   symptoms when stomach ulcer , and erosive lesions of gastroduodenal Department   - Experts prescribe patients to take daily 20 mg of the drug;
• oesophageal reflux   - 20 mg of the drug per day. Therapies designed on average per month. If the patient is completely cured, the course can be repeated;
• oesophageal reflux   in step remission   - Appoint experts to take 10 mg per day Losek ITA, if needed, the dose can be increased up to 20-40 mg. Admission is designed for long-term maintenance therapy;
• pain, discomfort, and heartburn   at epigastric , Related of acid dyspepsia   - Start with a daily dosage of 10 mg, which if necessary can be increased to 20 mg. Therapies designed to 4 weeks. If symptoms do not disappear at the end of the course, it is desirable to change the treatment regimen;
• severe form oesophageal reflux   - 40 mg of the drug per day. Therapy is usually designed for 2 months;
• symptomatic gastroesophageal reflux - dosages established in each case individually. Usually take 10-20 mg daily. Therapies designed to 4 weeks. If the symptoms of its end did not disappear, it is advisable to change the treatment regimen Losek MAPS;
• Zollinger-Ellison   - Dosage in each case individually. The recommended dose for initiation of therapy - 60 mg daily. If the daily dosage greater than 80 mg, it must be divided into 2 doses.

If the patient has problems with liver function, bioavailability   and clearance   active substance Losek CI increased, so that the daily dosage usually should not be more than 20 mg.

Overdose

Individual dosages of the drug to 400 mg, taken orally It does not cause severe symptoms. Rate of excretion of the drug at high doses does not increase. Specific therapy is required.

Cooperation

The combination of CI and Losek Ketoconazole   It may reduce the degree of absorption of the latter.

In addition, the drug may increase the excretion time Warfarin . Phenytoin   and Diazepam . Therefore, it may need to adjust dosages. But daily use of 20 mg Losek ITA does not affect the   Phenytoin   plasma during prolonged treatment, and does not change the coagulation at long application Warfarin .

The combined use of omeprazole and Clarithromycin   causes an increase in their plasma concentrations.

Terms of sale

Sold in the pharmacy network only for its intended purpose specialist.

Storage conditions

Store the drug should be at a temperature of 25 ° C. Cover the vial should be well closed after use of the drug. Keep out of the reach of children.

Shelf life

Three years from date of manufacture. Do not use medication after the expiry date.

Analogs Losek MAPS

Match code ATC 4th level:

• Losek
• Sanpraz
• Emanera
• Omez
• Insta omez
• Rabeprazole
• Kontrolok
• Ortanol
• Nexium
• Nolpaza
• Geerdin
• Omeprazole
• Lansoprazole

The most common analogs Losek MAPS:

• Ultop ;
• Losek ;
• Helitsid ;
• Omeprazole ;
• Omitoks .

Each of these drugs has its own nuances of the application, so that they do not take their own without a doctor's prescription.

Reviews Losek MAPS

Reviews Losek ITA as a preparation for the treatment of   peptic ulcers   very positive. Patients say quick action and efficacy of medicines. Symptoms such as heartburn It disappears at the beginning of therapy.

Among the disadvantages reviews of Losek ITA report only relatively high price and an uncomfortable amount of pills. In addition, some patients write about adverse events, such as nausea at the beginning of the course.

Price Losek CI, where to buy

Price depends on the form of tablets release. The cost of funds for the 10 mg (14 pieces per pack) - 200 rubles. And the price Losek CI 20 mg - about 230 rubles.

Get the best price and buy