Description overdue on 11/13/2014
- Latin name: Avodart
- ATC code: G04CB02
- Active substance: Dutasteride (Dutasteride)
- Manufacturer: SA GlaxoSmithKline Pharmaceuticals, Poland
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Avodart (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
The composition of one capsule of medicine: dutasteride 0, 5 mg plus additional ingredients (butylhydroxytoluene, gelatin, titanium dioxide, triglycerides, caprylic acid mono-diglycerides, glycerol , Iron oxide black, red ink for printing, lecithin).
Product form
The drug is released in the form of yellow opaque opaque capsules. Each capsule is printed in red ink GX CE2. In cartons of 30 or 90 pieces (10 in a blister, 3 or 9 blister pack).
Pharmacological action
Antiandrogens .
Pharmacodynamics and pharmacokinetics
Active ingredient means - dual inhibitor of the enzyme 5-alpha reductase . The substance inhibits the conversion process Testosterone at DHT By suppressing the activity 5-alpha reductase 1 and 2 diabetes. After all, dihydrotestosterone responsible for development hyperplasia . This reduces the size of the prostate, normal urination, increased probability of treatment without surgical intervention.
The higher dose of the drug taken, the more it affects the production DHT. His means of reaching the maximum influence through one - two weeks after the start of treatment.
The maximum drug concentration in serum is reached after about 1 5 hours after administration. Bioavailability - 60% (as compared to intravenous administration). Food intake has no effect on performance.
In preparation is very high degree of binding to plasma proteins, about 99%. About 11, 5% of the active ingredient in a systematic long reception gets into sperm.
In a living organism Avodart extensively metabolized. Excretion of 1-15% of the material going through the intestines in unchanged form, 74% are 4 major metabolite, 5% - Other minor metabolites. Completely out of the body the drug appears approximately one month after the deadline. However, even after 6 months of its minor amount found in serum.
Older patients no significant changes in any pharmacokinetic indicators. This suggests that the dose adjustment is not necessary.
Indications
The drug is prescribed:
- as part of comprehensive treatment prostatic hyperplasia or for preventing, in conjunction with Alpha-blockers ;
- monotherapy prostatic hyperplasia .
Contraindications
The drug is contraindicated in allergies its components, women and children.
If you have liver disease should be careful.
Side effects
The incidence of adverse reactions and their character depends on the duration of use and the availability of auxiliary treatment preparatovpri hyperplasia .
Tracking:
- hives , Itchy rash, swelling, and other allergic reactions up to angioedema ;
- depression Apathy;
- testicular swelling and pain;
- gipertriho s and hair loss on the body surface;
- erectile dysfunction , Decreased libido and libido , problems with ejaculation , Pain and swelling of the breast.
The likelihood of undesirable side reactions decreases with increasing duration of use (in the second year of the drug).
When combined with other drugs Avodart incidence of side effects may vary.
Instructions on Avodart (method and dosage)
The drug is administered alone or in combination with tamsulosin .
Instructions for use Avodart for adults
Recommended intake of 1 capsule (0, 5 mg) per day. Orally . The capsule should not be chewed or crack, its contents can damage the lining of the mouth or throat.
Medicine drink regardless of the meal. Minimum time receiving funds - six months.
In diseases of the kidneys and liver must be taken with caution means. In severe liver failure drug is contraindicated.
Overdose
According to clinical studies, patients who took 40 mg of drug per day for a week, did not reveal abnormalities.
When receiving 5 mg per day for six months, and abnormalities have been identified.
The drug has no specific antidote If the overdose does happen, it is recommended symptomatic therapy.
Cooperation
Drugs - inhibitors of isoenzyme cytochrome P450 CYP3A4 can increase the concentration of dutasteride in blood. It is proved that verpamil and diltiazem lower clearance preparation, but Amlodipine and others BPC It does not increase the drug concentration in the blood. Therefore, correction is not required daily dosage.
The drug can be combined with warfarin, kolestiraminom, acenocoumarol, tamsulosin, phenprocoumon, terazosin, digoxin, phenytoin and diazepam .
There were no adverse drug reactions when combined with ACE inhibitors . BPC . diuretics . PDE5 inhibitors . lipid-lowering drugs . beta-blockers . Corticosteroid . NSAIDs . quinolone antibiotics .
Isozymes CYP1A2, CYP2E1, CYP2C9, CYP2D6, CYP2C19, CYP2A6, CYP2C8, CYP2B6 are not involved in drug metabolism.
Terms of sale
We need a recipe.
Storage conditions
Do not allow children. Store in a cool place in original packaging.
Shelf life
4 years.
Cautions
Capsules can not disclose their contents to prevent contact with the skin or mucous membranes. If the fluid gets on your skin, immediately wash it under running water. Especially avoid contact with the drug should be women and children.
Despite the fact that there is established a direct and close depending on the medication and the development of heart disease, during studies have shown that the combination of dutasteride from Alpha-blockers slightly increases the risk of the disease.
Patients with serious violations of the liver should avoid taking this tool.
Before prescribing medication and in the process of treatment is necessary to produce a study of the prostate (digital rectal, assays PSA ). Six months after starting the drug should define the new entry-level PSA to continue to monitor it carefully. It should be remembered that any (even within the normal range) Increasing postatspetsificheskogo antigen It may be a signal about the development prostate cancer .
Within six months after the drug level PSA returns to normal.
Do not proven and found a direct relationship between drug intake and development Breast Cancer men.
During a 4-year study dutasteride It was proved that his method does not increase the likelihood of well-differentiated prostate cancer. However, men who took the drug, should monitor the PSA .
Clinically significant relationship quality and quantity of sperm on the duration of the reception facilities have been identified.
Analogs Avodart
Common counterparts: Adenosterid, Proscar, Urofin, Finpros, Penester, prostane, Finistere .
Price analogues tend to be slightly higher than the original.
Penester or Avodart - which is better?
Penester has a different active substance - Finasteride . Unlike the original, it can be combined with other drugs. Also prepara-analogue has minimal side effects. Both tools are effective in the fight against prostatic hyperplasia. Much depends on the individual.
Comments about Avodart
Reviews of Avodart on the various forums. Some write that after a year of use of the drug decreased the prostate, but discontinuation increased slightly again. Others are unhappy with the high cost of the drug. There are reviews, in which men are indignant at the decline of libido and Erectile Dysfunction in the first months of receiving the funds. In this case, it should be noted that normal sexual function, as a rule, is adjusted on the expiration of 3-4 months after the start of treatment. The incidence of adverse reactions is small, but there are cases of severe intolerance to the drug and the emergence of the lost hair.
Price Avodart
On average, the price of the drug is about 1 599 rubles per 30 capsules.
What is the cost to buy in Moscow? Price Avodart in the capital of Russia is about 3600 rubles per 90 tablets.
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