Description overdue on 07/12/2014
- Latin name: Urdoxa
- ATC code: A05AA02
- Active substance: Ursodeoxycholic acid (Ursodeoxycholic acid)
- Manufacturer: Farmproekt ZAO, Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Urdoksa, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
The composition of the tablets is 250 mg ursodeoxycholic acid + Magnesium stearate, corn starch, titanium dioxide, colloidal anhydrous silica, methyl hydroxybenzoate, acetic acid, gelatin, propyl.
Product form
The drug is released in the form of small opaque gelatin capsules. Color: white or almost white. Capsules firm within each - white or almost white powder.
The capsules are sold in packages of cellular contour, 1, 2, 3, 4, 5 packs into cardboard pack. Or in banks of 50 or 100 pieces.
Pharmacological action
Hepatoprotectors, choleretic and cholelitolitic means.
Pharmacodynamics and pharmacokinetics
Besides hepatoprotective and choleretic action, the drug has the ability to lower cholesterol and to stimulate job immune system .
Ursodeoxycholic acid embedded in the membrane envelope hepatocyte cells Thereby stabilizing the structure and protecting cells from the effects of bile acid salts. The drug has the ability to reduce the level of dangerous acids - chenodeoxycholic, deoxycholic and other stimulating activity calcium-dependent alpha-protease .
The drug reduces the synthesis cholesterol in the liver and its concentration in the bile, it stimulates the production of bile and its excretion. There is a strengthening pankeraticheskoy and gastric secretion.
When taken orally, it is capable of dissolving cholesterol stones and reduce cholesterol , generally. The tool increases the number of T-lymphocyte , Education IL-2 It reduces the amount of eosinophils , Thereby stimulating cellular immunity .
Absorption means occurs fine and ileum . The maximum plasma concentration - 5, 5 mmol per liter observed in about an hour. The active substance is almost completely (99%) bound to plasma proteins. Efficacy is linearly dependent on the concentration of the acid in the bile and the number received medication.
Means undergoes metabolism in the liver, followed by its active metabolites are excreted in bile (approximately 60%). Only a small part of it is cleaved by bacteria in the colon.
Indications
The indications for use of the drug is:
- biliary reflux gastritis ;
- primary cirrhosis Without decompensation ;
- the need for dissolution gallstones small and medium-sized, with its normal functioning.
Contraindications
The drug is contraindicated for use:
- acute inflammatory bowel disease, gall bladder and ducts;
- with severe kidney, liver and pancreas;
- pregnant and lactating women;
- if the gallbladder has ceased to function;
- in the presence of gallstones with a high content of calcium;
- children (under 18 years);
- at decompensated cirrhosis ;
- at allergies means for the components.
Side effects
The most commonly occur: pain epigastric . right upper quadrant ; abdomialnaya pain ; constipation or diarrhea .
Also available:
- calcination gallstones;
- increase in liver enzymes;
- nausea and vomiting;
- dizziness ;
- psoriasis ;
- alopecia ;
- allergy , Skin rash, hives .
Urdoksa, instructions for use (method and dosage)
The drug is taken orally, with water, and not sharing raskusyvaya capsule.
The dosage and duration of administration of agents are different depending on the disease to be appointed by the attending physician.
Instructions for use Urdoksy
For treatment primary biliary cirrhosis dosage is adjusted depending on the weight:
- if the patient's weight to 50 kg, is administered 2 capsules spread over two stages;
- body weight from 51 to 65 kilograms appoint 3 capsules a day for 3 admission;
- if the weight of 66 to 85 kg - one tablet in the morning, one at lunch and 2 before going to bed;
- with a weight of 86 to 110 kg - one tablet in the morning, 2 in the afternoon and 2 in the evening;
- if the patient's weight is over 110 kg, the daily dose will be 6 capsules, distributed into 3 doses.
To dissolve cholesterol gallstones Appoint 250-500 mg of drug per day (one or two tablets). The drug is taken during and after meals, for 4 to 12 months. As a precaution, take 1 tablet a day.
For treatment biliary reflux gastritis 1 capsule, 1 times a day. Course duration is determined individually by your doctor.
Overdose
There were no reported cases of overdose means. If overdose is still occurred, should be taken kolestriramin Which forms chelating bile acid.
Cooperation
It is not necessary to combine the drug with kolestiraminom and other means, reduces the degree of absorption of bile acids in the intestine, Estrogen . lipid-lowering drugs . hormonal contraceptives . hepatotoxic drugs.
Terms of sale
We need a recipe.
Storage conditions
Keep the medication you need in a cool, dry place, without direct access to sunlight. Keep away from children.
Shelf life
4 years. If expired, the drug is not recommended to take.
Cautions
If the medicine used to dissolve gallstones, to achieve good results and minimize the potential for adverse reactions, should comply with certain conditions:
- stone size - less than 20 mm;
- Stones should be rentgennegativnymi ;
- gall bladder should not be inflamed, it should continue to function;
- Bubble stones can be filled no more than halfway.
Each month (initially) or 3 months (treatment about six months) is necessary to make the control level liver enzymes . Then, during the three months after the complete dissolution of the stones, the drug must be taken for prevention.
Analogs Urdoksy
Ursosan
Livodeksa
Ursol
Ursofalk
Analogues: Choludexan, Livodeksa, Urso, Ursosan, Ursodez, Ursodeks, Ursol, Cursor, Ursofalk, Ekskhol, Ursodeoxycholic acid .
Ursosan or Urdoksa - which is better?
The original and its counterpart are indistinguishable from each other. Urdoksa and Ursosan - The same drug. Their only difference is in the country of origin. Urdoksa - Domestic analogue Ursosan While the raw material for the manufacture of the drug purchased abroad. Therefore, both drugs may differ unless value. In this case, Urdoksa some cheaper than its counterpart.
Reviews Urdokse
On the Internet there are mostly positive reviews Urdokse . People taking the medicine, basically satisfied with the result. Some complain of adverse reactions in the form of hair loss, back pain and nausea.
Price Urdoksy
Price Urdoksy is about 1000 rubles for 100 capsules of 250 mg.
Price Urdoksy Yekaterinburg - 650 rubles 50 capsules.
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