Oktolipen

Description overdue on 07/08/2014

• Latin name: Octolipen
• ATC code: A16AX01
• Active substance: Thioctic acid (Acidum thiocticum)
• Manufacturer: Pharmstandard-UfaVITA (Russia)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Oktolipena
• Contraindications
• Side effects
• Oktolipen - Instructions for use
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The active ingredient of the drug - thioctic acid   (α-lipoic acid).

Auxiliary components in capsules and tablets: calcium hydrogen phosphate dihydrate . magnesium stearate . colloidal silicon dioxide . Medicinal gelatine . quinoline yellow E 104 . Titanium dioxide E 171 . colorant sunset yellow E 110 .

Supporting components of the concentrate for solution for infusion: ethylenediamine , Water for injection, disodium edetate.

Product form

Oktolipen available in capsules   and tablets Film-coated. Another type of issue - concentrate for solution for infusion.

Pharmacological action

Neuroprotective, hypoglycemic, hypocholesterolemic, hepatoprotective, and lipid-lowering agents.

Pharmacodynamics and pharmacokinetics

The main active ingredient of the drug is endogenous antioxidants .

Thioctic acid   reduces glucose concentration in the blood helps to overcome insulin resistance And increases the concentration of glycogen in the liver. Similar in nature to the action of B vitamins takes part in lipid and carbohydrate metabolism, improves liver function, stimulates exchange cholesterol .

Furthermore, thioctic acid acts as hepatoprotective . hypocholesteremic . gipolipidemicescoe   and hypoglycemic   means. It improves trophic neurons It reduces the expression of alcoholic and diabetic polyneuropathy Activates axonal conduction .

Concentrate for solution for internal administration reaches a maximum concentration - 25-38 mg / ml. The volume of distribution - about 450 ml / kg.

Capsules and tablets are absorbed when administered in a short time. If consumed during meals, absorption decreases. Bioavailability is 30-60%. Maximum concentration in blood reached 25-60 minutes.

Regardless of the dosage form of the drug by the liver by conjugation and oxidation of the side chain. Excreted through the kidneys approximately 80-90%. Half-life - 20-50 minutes.

Indications Oktolipena

Indications Oktolipena capsules of 300 and 600 mg:

• diabetic polyneuropathy genesis ;
• polyneuropathy alcoholic genesis .

Indications Oktolipena as a solution for infusion and 12 mg 25:

• fat dystrophy liver;
• chronic hepatitis ;
• intoxication ;
• hyperlipidemia ;
• cirrhosis liver ;
• hepatitis A ;
• pale toadstool poisoning.

Contraindications

Contraindications to the use of the drug as follows:

• Hypersensitivity to the components of the drug;
• pregnancy ;
• period Lactation ;
• children's age.

Side effects

In the application of the drug may be the following side effects:

• appearance allergic reactions   (possible even anaphylactic shock);
• on the part of the digestive tract is possible nausea . heartburn . vomiting ;
• symptoms hypoglycemia .

Oktolipen - Instructions for use

For those who have appointed a capsule or tablet Oktolipen, instructions for use provided the reception in the morning on an empty stomach half an hour before meals daily dose. Simultaneous consumption of food reduces the effectiveness of the drug. Grind and chew tablets, and capsules are also not recommended.

The daily dose, which provides instructions for use Oktolipena - 600 mg (1 tablet or 2 capsules). However, the duration of the course and the final dose determined by the physician.

To increase the effectiveness of the drug in some cases the first 2-4 weeks of use prescribed concentrate for preparing infusions, then in the standard dose used capsules or tablets.

To prepare the solution used 1-2 ampoules, which are diluted in 50-250 ml of 0, 9% sodium chloride solution. After cooking, it is administered intravenously. The standard dose - 300-600 mg per day.

The preparation is sensitive to light, so the vials must reach only immediately before use. At this time, it is also desirable to protect the vial from sunlight. The prepared solution must be stored in a well-protected from light and no longer than 6 hours after preparation.

Overdose

Because drug overdose may occur headache . vomiting   and nausea . Treatment is symptomatic.

Cooperation

The drug stimulates hypoglycemic action   Insulin and antidiabetic agents, which are taken orally. That is why the combination of these drugs need to continuously monitor the glucose content in the blood plasma and adjust the dosage of antidiabetic drugs, if necessary.

Furthermore, it should observe a half-hour interval between doses Oktolipena and dairy products, and also preparations with iron, calcium and magnesium. It is advisable in this case to take Oktolipen in the morning, and the means of iron, magnesium and calcium - the evening. Additionally, this reduces the effect of the medication Cisplatin   while use.

The effectiveness of the Oktolipena reduces ethanol. So during the course of this drug is recommended to abstain from alcohol.

Thioctic acid also activates the anti-inflammatory properties glucocorticosteroid funds .

Terms of sale

Sold in pharmacies strictly on prescription.

Storage conditions

Store this medication should be in a dry, well-sheltered from sunlight, out of reach of children. Storage temperature - 15-25 ° C.

Shelf life

Oktolipena Shelf life - 2 years.

Analogs Oktolipena

Match code ATC 4th level:

• Mummies
• Omez JEM
• Thioctacid
• Tiogamma
• Figurin
• Aktovegin
• Berlition

Pharmacies can get these analogues Oktolipena:

• Alpha-lipoic acid ;
• Berlition ;
• Lipamida ;
• Lipotiokson ;
• Neyrolipon ;
• Tiogamma ;
• Thioctacid ;
• Thioctic acid ;
• Tiolepta ;
• Tiolipon ;
• Espa-lipon .

The most common of these is Neyrolipon .

Reviews Oktolipene

Reviews Oktolipene usually positive. Many patients say its sheer efficiency. Sometimes it is offered at pharmacies instead of more expensive Berlition . Reviews Oktolipene thus say that the effect of the drug is as effective as its counterpart.

Price Oktolipena where to buy

Price Oktolipena ampoules average from 350 to 400 rubles. Thus the cost of tablets and capsules somewhat smaller. Price Oktolipen tablets as well as capsules, mostly - about 270 rubles.

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