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Biotransformation sibutramine in the liver, and the active form metabolites . The highest concentration of the drug plasma It occurs after 1-1.5 hours after a single administration, after 3 hours for active metabolite. In metabolism PM is not affected by age, sex, weight of the patient.
Indications and methods of use of the drug:
The drug is prescribed for patients with lindaksa alimentary obesity Whose body mass index greater than 30 kg / m2. It is used in alimentary obesity with a BMI of 27 kg / m2 or more, which combines non-insulin diabetes or dyslipoproteinaemia .
The dose of the drug receiving specialist should set individually. Ingestion in the morning, eating at the same time does not matter. The initial dose should be 10 mg. If the effect is not observed, that is, it resets the patient for at least 2 kg for four weeks, then if tolerated dose of agent can be increased to 15 mg per day. In the absence of effective exposure treatment should not continue.
No need to continue therapy after three months of taking the drug to those patients who have failed to lose weight during this time by 5% from the initial level.
We should not practice further treatment, if after a weight loss during the treatment according to the patient drugs gaining more than 3 kg. Duration of the drug can not continue lindaksa bole two years after the security information of the drug over a long period of time is absent.
Contraindications and possible side effects:
The drug should not be used under the following conditions: organic causes of obesity, severe eating disorders, mental illness, syndrome of Gilles de la Tourette . You can not use the drug while treating MAO inhibitors or when they are used for two weeks prior to admission Meridia , Taking serotonin reuptake inhibitors, hypnotics, drugs that contain tryptophan And other drugs for weight reduction of the central action. The drug is contraindicated in diseases of the cardiovascular system, pheochromocytoma , Uncontrolled hypertension . thyrotoxicosis , Severe violations of the liver, kidney, benign prostatic hyperplasia , Closure glaucoma . Do not use drugs lidaksa during pregnancy and breastfeeding. The drug should not be prescribed to children, adolescents, people over 65, those who have seen drug, alcohol, drug dependency, high sensitivity sibutramine .
Caution when administered drugs arrhythmias at history . cholelithiasis , Congestive heart failure, hypertension , Neurological disorders, disturbances in the functioning of liver, kidney, mild to moderate, with a history of motor and verbal tics.
Adverse effects during the treatment may occur in the first three to four weeks of use of the drug. Over time, their frequency and intensity are less pronounced. In the CNS and peripheral nervous system can occur insomnia (often), dizziness, headaches, paresthesia , Anxiety, change in taste (sometimes). In the cardiovascular system is manifested tachycardia , Increased blood pressure, vasodilatation (sometimes). In the digestive system may be dry mouth, reduced appetite, constipation (common); sometimes it may appear nausea, exacerbation Hemorrhoids . As a side effect may appear high perspiration. Also disclosed are isolated instances of dysmenorrhea , Edema, influenza-like syndrome, back pain and abdominal pain, pruritus, increased appetite, thirst , Depression, drowsiness, rhinitis, anxiety, irritability, acute interstitial nephritis, bleeding . Henoch-Schönlein . seizures . thrombocytopenia .
Specific recommendations:
Store this medication lindaksa should be at a temperature not exceeding 30 ° C. Shelf life is 2 years from the date of issue.
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