Losek

Description overdue on 11/30/2014

• Latin name: Losec
• ATC code: A02BC01
• Active substance: Omeprazole (Omeprazole)
• Manufacturer: AstraZeneca (Sweden)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Loseka (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The active component of the drug Losek (Losec) - omeprazole .

Additional components: disodium edetate dihydrate, sodium hydroxide.

Product form

The drug is available as a lyophilisate for the preparation of the infusion solution.

Pharmacological action

The drug belongs to antiulcer   Drugs.

Pharmacodynamics and pharmacokinetics

This medication inhibits acid secretion   by inhibiting gastric proton pump of parietal cells . The main ingredient of the drug in the acidic environment of the stomach enters in active form. It has an effect on the final step of the synthesis of hydrochloric acid and inhibits secretion ( basal   and stimulated ) Regardless of the active agent.

Decreasing intragastric secretion   It is maintained throughout the day after administration.

The degree of association with the plasma protein - 95%. Half-life on average - 40 minutes. Once in the body, the active substance is completely biotransformed. Metabolites Which are formed after that, no effect on gastric acid secretion . Approximately 80% of the dosage is excreted as metabolites   via the kidneys. The remaining part - through the intestines.

In patients with impaired liver function, an increase in half-life. In old age, time metabolism   the drug has slowed somewhat.

Indications

The drug is indicated in the following cases:

• Zollinger-Ellison ;
• treatment peptic ulcer   in combination with antibiotics   to Helicobacter pylori eradication ;
• duodenal ulcer ;
• long-term treatment of patients with inactive reflux esophagitis ;
• gastric ulcer ;
• the need to prevent ulcers of the stomach and duodenum   because of the application NSAIDs ;
• the need to prevent the re-development duodenal and / or gastric ;
• therapy ulcers of the stomach and duodenum Which involves using NSAIDs ;
• symptomatic gastroesophageal reflux disease ;
• reflux esophagitis .

Contraindications

Hypersensitivity to the drug.

Side effects

When receiving the drug, the following side effects:

• skin - dermatitis , skin rash, itch . hives ;
• nervous system - headache . dizziness . drowsiness . paresthesia . insomnia ;
• GIT - abdominal pain . diarrhea , nausea, vomiting, constipation . flatulence ;
• common disorders - malaise ;
• liver and bile duct - increase in liver enzymes ;
• hearing - vertigo .

In rare cases, may also experience the following symptoms:

• alopecia ;
• erythema multiforme ;
• Lyell's syndrome ;
• photosensitivity reaction;
• Stevens-Johnson syndrome ;
• taste disturbance;
• dry mouth;
• gastrointestinal candidiasis ;
• stomatitis ;
• microscopic colitis ;
• gynecomastia ;
• fever ;
• anaphylactic shock ;
• angioedema ;
• interstitial nephritis ;
• blurred vision;
• increased sweating;
• peripheral   swelling ;
• arthralgia ;
• muscular weakness ;
• myalgia ;
• irritability;
• impaired consciousness;
• hallucinations ;
• aggressiveness;
• depression ;
• hepatitis ;
• encephalopathy   in the case of liver dysfunction;
• hepatic failure ;
• leukopenia ;
• agranulocytosis ;
• thrombocytopenia ;
• pancytopenia ;
• bronchospasm ;
• blurred vision;
• hyponatremia ;
• hypomagnesemia ;
• hypokalemia ;
• hypocalcemia.

Instructions for use Loseka (method and dosage)

Losek instructions for use advises taking unless suitable Oral   form of the drug. Recommended Dosage - 40 mg once a day. At Zollinger-Ellison syndrome   the initial daily dose - 60 mg. If necessary, it can be increased after consultation with a specialist. But then the dose should be equally divided into two parts.

Infusions   made for 20-30 minutes. Injections must be applied for sodium chloride 0, 9% or 5% glucose solution. Stability of the active drug substance is dependent on the solution pH, so it is necessary to use a solvent.

Using a syringe should dial 5 ml solution for internal administration to a 100 ml bottle. Then add it to the vial with freeze-dried omeprazole   and mix well. The drug should be dissolved. The resulting solution was again withdrawn into a syringe, and then transferred into a bottle for infusions . Actions are repeated up to 4 times, until all omeprazole   It will not be transferred to the bottle infusions .

The preparation for internal administration may also be prepared in a flexible container. For this purpose, the double-sided needle adapter. One end is attached to injection membrane   bag infusion And the other - to the bottle lyophilized drug. The powder is dissolved by means of pumping infusion solutions   between the bag and the vial. At the end of the procedure, make sure that omeprazole   dissolved.

Instructions for use Loseka said that if a single infusion the solution is not fully used, any amount should be utilized.

In the case where the medicine is used in patients with impaired liver function, the dosage is reduced to 10-20 mg per day.

Overdose

With the introduction of the drug in higher doses may dizziness . headache . phlebarteriectasia , Nausea, flatulence , Lethargy, confusion, tachycardia , Vomiting, diarrhea .

Symptomatic therapy. It is believed that hemodialysis   is not effective.

Cooperation

The combination omeprazole   and Saquinavir   causes an increase in the content of the latter in plasma . A by reaction with Tacrolimus   drug increases its concentration in blood serum. So you need to constantly monitor the level of Tacrolimus   and the kidneys. If necessary, the dosage adjusted.

It is recommended not to combine the application Loseka Methotrexate   in high doses.

Interaction with Voriconazole   It may lead to increased exposure omeprazole   more than twofold. So if such a combination is assigned to patients with renal failure , Dosage adjustment may be necessary during prolonged therapy.

Drugs inducing activity CYP2C19   and / or CYP3A4. may reduce the content of active substance Loseka serum.

Do not take together with Atazanavir   and Nelfinavir . The drug may also reduce the absorption Ketoconazole   and extend elimination of warfarin . Phenytoin and Diazepam   (because of which may require a reduction of dose).

Terms of sale

The drug prescription.

Storage conditions

Losek unopened box should be kept protected from sunlight at temperature up to 25 ° C.

If the original carton is printed, the drug is stored in a place protected from sunlight place at room light for no longer than a day. The prepared solution for internal administration must be applied within 12 hours, and if used as a solvent solution, dextrose 5% - less than 6 hours.

Use of the drug after the expiry date is strictly prohibited.

Shelf life

Two years. The date of manufacture shall be indicated on the packaging.

Analogs

Match code ATC 4th level:

• Losek MAPS
• Sanpraz
• Emanera
• Omez
• Insta omez
• Rabeprazole
• Kontrolok
• Ortanol
• Nexium
• Nolpaza
• Geerdin
• Omeprazole
• Lansoprazole

Known analogs of this drug:

• Omeprazole ;
• Gasek ;
• Diaprazol ;
• Loseprazol ;
• Ozol ;
• Omealoks ;
• Omez ;
• Insta omez ;
• Omelik ;
• WES ;
• Omeprazole Euro ;
• Omeprazole-Astrafarm ;
• Omeprazole vocals ;
• Omeprazole-Darnitsa ;
• OLEDs ;
• Ultop ;
• Losek MAPS .

The difference Losek and Losek MAPS

The main difference and Losek Losek MAPS   in the form of release. The last drug is sold in tablets. Because of this it has a slightly different composition. Experts advise to use solution for internal administration, but if you do not fit Oral   form of the drug (contraindications, side effects, etc.).

Reviews on Losek

The online reviews Losek usually positive. Patients mark speed and efficiency of the tool. People suffering from   ulcers Have reported that the pain and tested heartburn It normalizes acidity disappear erosion . The accolades write that means successfully replaces all similar medicines.

Price Loseka where to buy

Some patients complain that the price Loseka for them is too high. That is why sometimes people look for analogues of this tool. Most pharmacies Loseka price is about 1,800 rubles.

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