Penkrofton

Description overdue on 25.03.2012

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Antigestagens steroid drug. Active, active component - mifepristone . Drug action is directed at blocking Penkrofton progesterone The level of action - gestagenovye receptors . Mifepristone has not progestin activity. With simultaneous admission glucocorticosteroids notes antagonism . The drug increases the sensitivity of the myometrium to the action of prostaglandins, stimulates the release of interleukin-in horiodetsidualnyh cells , Increases the contractile activity   myometrium . Penkrofton allows to deduce ovum   After desquamation decidua. The drug is available in tablet form.

Indications and contraindications:

Penkrofton indicated for termination of pregnancy in the early stages (suspended to 42-yi days amenorrhea   uterine pregnancy). The drug is used during the preparation and induction of labor at term. Penkrofton not prescribe mifepristone intolerance, prolonged glucocorticosteroid therapy, n adpochechnikovoy failure , Porphyria, anemia, scarring of the uterus, uterine cancer, liver failure and renal systems abuse   hemostasis , Severe extragenital disorders, inflammatory diseases of the female genitals. Mifepristone is not indicated in women older than 35 years with nicotine dependence. If you suspect ectopic pregnancy   the drug is not prescribed. The preparation, induction of labor: Penkrofton contraindicated in eclampsia , Preekslampsii, severe preeclampsia, prolonged pregnancy. In severe asthma, hypertension, COPD, cardiac arrhythmias prescribed with caution.

Side effect:

Penkrofton subinfolyutsiyu can cause uterine lohimetru, metrorrhagia, pain and discomfort in the epigastric pain, chills, pyrexia, dizziness, diarrhea, vomiting, nausea, headaches, weakness, worsening of infections of the genitourinary system. In combination therapy with misoprostol causes dyspepsia, vaginitis , Bleach, fainting, anemia, anxiety, pain in the legs, fatigue, insomnia, decrease in hemoglobin.

Mode of application:

Penkrofton administered only in hospitals and equipped facilities. For the purpose of medical abortion prescribe a single dose of 600mg of the drug in the presence of a doctor. To further enhance the effect of 400 mg mizopristola applied. The women are observed within two hours (minimum) after dosing Penkrofton. 36-48 hours spend US control. After 8-14 weeks determine the level of beta-hCG and repeat ultrasound to confirm the removal of the ovum from the body. In case of failure of the therapy on 14 day hold vacuum aspiration mandatory fence aspiration for histological examination. The preparation, induction of labor: in the presence of a doctor woman taking 200 mg of the drug. Receiving repeated after 24 hours at the same dosage. After 48-72 hours assess the condition of the birth canal, they decide on the supplemental Oxytocin   and prostaglandins.

Special instructions:

The doctor is obliged to warn the woman that in case of failure of the therapy drug Penkrofton will be necessary to terminate a pregnancy expeditious way (increased risk of congenital malformations in the fetus). Breast-feeding must be stopped on the 14th day after treatment. The drug is administered only in a hospital. Patients with infective endocarditis   and artificial heart valves in parallel are treated with antibiotics.

Drug Interactions:

Invalid simultaneous reception of preparations of NSAIDs.