- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Riboxinum
- Contraindications
- Side effects
- Instructions for use Riboxinum (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
1 tablet pharmaceutical formulation contains:
- Riboxinum - 0, 2 g;
- Calcium stearate;
- Potato starch;
- Powdered sugar;
- Mixture coating «Opadry II Yellow - indigo carmine (E 132) Lactose monohydrate, titanium dioxide (E 171), Macrogol (polyethylene glycol 3000), quinoline yellow (E 104), iron oxide (E 172).
Composition of solution for injections:
Product form
- 2% injection in ampoules of 10 ml (total content of the main active substance - 200 mg). The carton holds 10 vials.
- Pills Riboxinum yellow coated with a biconvex surface. The cross section can be easily seen the two layers. Packaged medication in contour cell blisters of aluminum foil or PVC 10 tablets. The pack contains 1, 2, 3, or 5 plates.
- Riboxinum Lect - capsules containing inosine - 0, 2 In carton invest 20, 30 or 50 pieces.
Pharmacological action
What Riboxinum?
Riboxinum - a drug anabolic character, which renders the nonspecific antihypoxia and antiarrhythmic action. The main active ingredient of the drug is Inosine (Inosine - INN or international non-proprietary name of the pharmaceutical product) - a chemical precursor adenosine triphosphate (ATP), are directly involved in the metabolism of glucose and contributes to the activation of metabolic processes in low-oxygen ("oxygen starvation").
Mechanism of action of drugs
Biologically active substances contained in the medicament activate the metabolism of pyruvic acid (STC), which provides normalization of tissue respiration even in the absence of the required amount of ATP. Existing components can also influence the enzyme component of metabolic processes - getting into the human body, they stimulate the activity of xanthine dehydrogenase Which in turn catalyzes the oxidation reaction followed by formation of uric acid from hypoxanthine.
Benefits and harms Riboxinum
Positive influence of the pharmaceutical preparations are the main components of the action Riboxinum metabolism in the myocardium (heart muscle). Thus, the therapeutic properties of the drug are shown in improving the energy balance of cardiomyocytes , Accelerated the formation of nucleotides, which manifests itself in strengthening the process of physiological regeneration cardiac tissue. That is, the drug helps to normalize the activity of myocardial contractility and fuller flow of diastole, when the heart relaxes completely due to its ability to bind calcium ions chemical chains that penetrate into the intracellular space during systole.
K negative Riboxinum influences include changes in physiological cycle sequence exchange . That is, the active ingredients of the pharmaceutical preparation, doing without, make adjustments to the metabolic processes. Usually, professionals are trying as much as possible not to interfere in this area of the biochemistry of the human body, as the therapeutic effects can cause very adverse consequences for the patient. However, in the presence of a pathological process, destructive effect on the heart muscle (a vital "pump" of the circulatory system), change in metabolism is necessary, because non-intervention would lead to a much more worse outcome.
Wikipedia about Riboxinum
The free encyclopedia of knowledge on the Internet also reveals some aspects of the pharmacological action of the drug. In particular it describes all the cardiac effects of biologically active components that make up the Riboxinum. In addition, on the page of this medication have information on the effects on cellular components of the blood coagulation system - Inosine reduces aggregation platelets than reduces the risk of thrombosis and thromboembolism . Regenerative therapeutic properties of the pharmaceutical preparation include not only the heart muscle, but also the mucosa of the gastrointestinal tract.
Of special note Inosine pranobek with - a kind of drug that has immunostimulatory activity and unspecific antiviral action. The drug suppresses harmful pathogens such as herpes simplex virus, CMV (cytomegalovirus), measles virus and T-cell lymphoma of the third type, enterotsitopatogenny human virus, and many others. The mechanism of this action is to inhibition of ribonucleic acid and braking digidropteroatsintetazy biological catalyst, which is manifested in the suppression of viral replication and enhanced development of lymphocytes interferon destroying pathological organisms.
Pharmacodynamics and pharmacokinetics
When taken orally Riboxinum well and almost completely absorbed in the gastrointestinal tract. When administered intravenously, the pharmaceutical quickly distributed tissue, who searches the need for ATP. Regardless of the route of administration, the unused active action components metabolized in the liver, where the last stage of metabolic biochemical reactions. A small number of Riboxinum excreted in the urine, feces and bile.
Indications Riboxinum
Indications Riboxinum tablets:
- Comprehensive treatment of coronary heart disease (angina, coronary insufficiency, a condition after myocardial infarction);
- Intoxication drugs cardiac glycosides;
- Cardiomyopathy of various origins;
- Myocarditis ;
- Rheumatic, congenital and acquired heart defects;
- Violation of cardiac rhythm;
- Myocardiodystrophy infectious or endocrine origin (especially against heavy physical exertion);
- Coronary atherosclerosis ;
- Non-specific liver disease ( hepatitis , Fatty degeneration of parenchymal organ, cirrhosis);
- Drugs and alcohol damage the liver;
- Urokoproporfirii ;
- Prevention of reducing the number of white blood cells by irradiation;
- Stomach ulcer and duodenal ;
- Open- glaucoma with normalized intraocular pressure.
Specific indications for the use of injections:
- Urgent pathologies cardiac arrhythmias;
- Operations on the isolated kidney (as a means of pharmacological protection during the temporary absence of circulation);
- Arrhythmias of unknown etiology in medicine;
- Acute radiation exposure to prevent the development of changes in the blood composition.
Contraindications
- Hereditary or acquired intolerance constituent components of the pharmaceutical preparation;
- Customizing hypersensitivity to the active ingredients of the drug;
- Podagra ;
- Renal failure ;
- Hyperuricemia (high amounts of salts of uric acid in the blood).
Side effects
Typically, the drug is well tolerated, only in a few cases, there are the following side effects:
- Hypotension ;
- Elevated levels of uric acid and its salts in the blood;
- Tachycardia ;
- Itching ;
- General weakness;
- The aggravation of gout ;
- Nettle-rash allergic origin;
- Redness of the skin.
Instructions for use Riboxinum (method and dosage)
Tablets Riboxinum, instructions for use
Tablets used orally inside, before meals. The dosage is usually determined individually in mind singularities metabolism of the active component and the indications for the conservative therapy. However, there are certain general regimens According to the pharmaceutical preparation, according to which the daily dose for adults and children over 12 years is 0, 6-2, 4 grams per day. Rehabilitation begins with small doses (about 0, 6-0, 8 g - 1 tablet 3-4 times a day), and then, if the drug is well tolerated and has a favorable effect on the body, the dose is gradually increased during 2-3 days.
Max receiving preparation is 2, 4 g knocks - 4 tablets 3 times a knocking. This dose achieved in the 2 month course of conservative treatment, the entire length of which usually lasts from 1 to 3 months and adjusted according to the individual indications for therapeutic intervention.
Of special note is how to take the pills when urokoproporfii Because the pathophysiology of the disease is associated with an increase in uric acid salts in body fluids and secretions. Riboxinum in turn speeds up the metabolism of urate, activating enzymatic oxidation of hypoxanthine. Therefore, in order to avoid deposits and the formation of stones, the dosage of the drug is 0, 8 g per day - 1 tablet 4 times a day and should be strictly adhered to conservative treatment.
Injections Riboxinum, instructions for use
Use a slow drip or parenteral administration fast jet injection Depending on the individual indications, and urgency of the pathological condition. If the doctor chosen injections, the first to use the minimum dosage of 200 mg Riboxinum (10 mL of 2% solution for injection), 1 per day. In severe violations heart rhythm can be used a single injection of 200-400 mg of inosine (10-20 ml of 2% solution) intravenously.
Bolus dosage increase only with good tolerability. Max the drug may be 400 mg Riboxinum (two vials 2% solution) 1 or 2 times per day. Duration of the course is individually (according to the general protocol - 10-15 days).
If you use Riboxinum / in (iv) drop , Before it is introduced 2% solution of the preparation must be diluted in 5% glucose or hypotonic sodium chloride solution (concentration - 0, 9%) to obtain 250 ml of the liquid formulation. The introduction rate - 40-60 drops of 1 minute.
Instruction during pregnancy
Riboxinum used intravenously to women "in position", because thus its effects are disclosed more fully. Dosage and duration of conservative therapy is chosen strictly individual in each case based on the results of various clinical trials and reviews skilled.
How to use Riboxinum Lect?
The dosage and duration of treatment of the variation of the pharmaceutical preparation do not differ from the standard therapeutic protocol assistance Riboxinum. However Lect-form of the drug is not used as an emergency correction of disorders of the heart muscle and other organs, as its effects are developing a little more slowly.
Overdose
In clinical pharmacological literature described cases of overdose According pharmaceuticals.
Cooperation
Combined use of the drug with cardiac glycosides It strengthens the inotropic effect of the latter and prevents the development of the adverse effects of drug treatment as the onset of an arrhythmia, which Riboxinum sometimes prescribed together with this group of pharmaceuticals.
Simultaneous use with such Riboxinum anticoagulants , as heparin prolongs their therapeutic effect.
The drug is completely incompatible with the acids and alcohols . pyridoxine hydrochloride or vitamin B6 As it is deactivated both chemical compounds, salts of heavy metals , Vegetable alkaloids . Last when they interact with Riboxinum form insoluble and output connections, as a result of removing the base alkaloid.
Terms of sale
The drug belongs to the B-list, because you can buy it only on presentation of the certified form of the receptor. Certain old-fashioned pharmacy kiosks may even require a prescription in Latin.
Storage conditions
The medicine should be stored in original packaging at temperature no higher than 25 degrees Celsius in the dry, out of reach of young children place. Also, the drug should be protected from direct sunlight.
Shelf life
4 years
Cautions
Riboxinum bodybuilding
The pharmaceutical preparation is classified as metabolic means stimulant and biochemical processes, because the drug can be used weight gain , Improve physical performance and improve power performance . Riboxinum in sports actively used in the distant 70s. Known varieties of food for bodybuilders, who are actively marketed to this day:
- Premium Inosine;
- Ultimate nutrition;
- Inosine mega-pro;
- Inosine life extension;
- Cell-tech hardcore.
As riboksin in bodybuilding?
In sports nutrition used Tablet form of the drug, which is assigned to inside to food. Dosage It is from 1 5 to 2 5 grams per day. As therapeutic purposes, the number of tablets to be increased gradually from a starting dosage of 0, 6-0, 8 g of 3-4 times a day until 2 5 g Riboxinum athletes use over 4 weeks to 1, 5 -3 months.
To enhance the impact of the drug on the myocardium and reduce the period of the medium-and climate adaptation can be applied together Potassium Orotate and Riboxinum. In this case, the dosage of the potassium salt of orotic acid is 0, 25-0, 5 g 2-3 times a day before meals (course duration is 15-30 days) and Riboxinum used for the above described scheme.
Riboxinum in veterinary practice
The drug is nonspecific pharmaceuticals in its nature, and therefore can be used in veterinary therapeutic practice. Often the drug is used for dogs in order to eliminate Heart Failure , Treatment myocarditis and endocarditis , Improved metabolic capacity muscular organ at myocardosis and heart defects Which are very common problems of senile animals.
As riboksin animals?
Typically, the drug is administered intramuscularly Because it is the most rational way of introduction in veterinary practice. Dosage is 0, 1-0, 2 g per 10 kg of body weight three times a day. The course of conservative treatment lasts about a month. Riboxinum possibility of reappointment for a thorough correction of metabolism or elimination of deep dystrophic changes.
Analogs Riboxinum
Analogs Riboxinum make the small number pharmaceutical group with identical main active ingredient - Inositol-F, Inosine, Riboxinum bufus, Ribonozin . As a rule, the price of these drugs is even lower, from which Riboxinum tablets can be substituted analogues of data for greater savings.
With alcohol
Riboxinum / in (iv) should not be combined with the use of alcoholic beverages, as it is fraught with side effects listed above or the emergence of new adverse effects of conservative therapy pharmaceuticals.
Riboxinum during pregnancy (and lactation)
The pharmaceutical preparation is actively administered in the most critical periods for women that usually throws mothers in slight bewilderment. Even after reading the manual is a lot of questions, most of which, of course, what Riboxinum during pregnancy. Medicine improves tissue metabolism and energy supply That is, it provides the woman and the fetus is more active intake of beneficial nutrients at a time when they are transferred deficient state. This is one of the main aspects of the use Riboxinum.
Also active ingredients help to reduce the harm caused by the so-called " oxygen starvation "Which is a common complication during pregnancy. There is a pathological state, as the respiratory system provides the vital female gas two organisms. But so powerful oxygen demand is at odds with the possibilities of the lung and bronchial tree. Because antihypoxia action Riboxinum has to be very helpful, and it is the second, but no less important aspect of the use of the drug during pregnancy.
Among the therapeutic properties of the pharmaceutical preparation of the considerable impact on the make cardiac activity . Riboxinum normalizes contractile activity of the myocardium, regulates the metabolic needs of cardiomyocytes, strengthens trophic processes. Thus the drug acts as a Preventive rehabilitation As it is not uncommon for pregnant women - the development of pathological processes such as arrhythmia, tachycardia, arrhythmias, and other activities of the heart muscle.
As riboksin for pregnant women?
The dosage and duration of use of the pharmaceutical preparation during pregnancy is always selected individually based on the performance of diagnostic tests, ultrasound data, and other physiological parameters.
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