Ribonuclease

Description overdue on 15-05-2012

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Proteolytic means Applied topically. A ribonuclease enzyme drug. The active component is obtained from the pancreas of cattle. The principle is based on the impact of the depolymerization of RNA to the level of acid oligopeptide , Monopeptidov. Ribonuclease thins the thick mucus, pus, sticky phlegm, mucus, has anti-inflammatory effects. The drug holds some views of the process of reproduction of RNA viruses by breaking nucleic acid . By the number of acid-soluble substances, which are released by the hydrolysis of RNA, the biological activity was evaluated by RNase. One unit corresponds to milligram ribonuclease activity (EA). Ribonuclease is available in the form of freeze-dried product.

Indications:

Ribonuclease appoint the pleural effusion, atelectasis , Bronchiectasis, respiratory system diseases with difficult, viscous phlegm, when asbtsessah lung sinusitis , Fistulas, osteomyelitis , Gingivitis, periodontal disease, trophic ulcers, otitis, tick encephalitis . thrombophlebitis .   viral meningitis .

Contraindications:

Ribonuclease not prescribed for respiratory failure, intolerance, open form TB , Hepatic failure system bleeding . When pleural empyema tuberculous origin of the drug is used with caution.

Side effect:

Ribonuclease can trigger an allergic response, cause irritation of the walls of the respiratory system.

Mode of application:

Ulcerous wound surface and sprinkle ribonuclease twice a day (25-50mg), applied on top of tampons or towels soaked in a solution of sodium chloride 0, 9% .  The fine aerosol for inhalation: 25 mg per procedure, the drug is dissolved in a solution of procaine 0, 5% NaCl 0 9% .  Endobrahealno ribonuclease is administered as a solution by laryngeal syringe special catheter 25-50 mg .  For the treatment of sinusitis in the maxillary sinus puncture after preliminary washing drive 5-10 mg of drug dissolved in 3-5 ml of sodium chloride solution .  When otitis in the external auditory canal is introduced 0, 5-1 ml of 0, 1% solution .  25-50mg of the drug is administered intrapleurally, procaine dissolved in 0 2% sodium chloride, 0, 9% .  The medicament is administered intramuscularly as a solution onto procaine, sodium chloride, duration of therapy, 1-2 injections 5days .  In intramuscular a maximum single dose of 10 mg, with intracavitary and local administration - 50 mg of ribonuclease .  Therapy encephalitis: 6 times a day for 25-50 mg intramuscularly .  Before use, hold the sample at the sensitivity to the drug .

Special instructions:

Bronchopleural fistula may develop as a result of absorption of fluid in the tuberculous pleural empyema .