Meloxicam

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Non-steroidal, anti-inflammatory agent . The main component has analgesic, antipyretic and anti-inflammatory effects. The active ingredient belongs to the class of oxicams is derived enolievoy acid . Principle effects of meloxicam formulation based on selective suppression of the enzymatic activity of COX-2, inhibition of synthesis of prostaglandins. The selectivity of cyclooxygenase-2 decreases during prolonged treatment with meloxicam in high dosages. The drug is most inhibits the synthesis of prostaglandins in inflammatory foci compared to kidney tissue, mucosal wall of the stomach. Meloxicam is less erosive and ulcerative lesions of the digestive tract. The drug is available in tablet dosage form, in the form of suppositories, solution.

Indications:

Meloxicam is prescribed for ankylosing spondylitis (ankylosing spondylitis) osteoarthritis , Rheumatoid arthritis, degenerative and inflammatory diseases of the joints, accompanied by severe pain .

Contraindications:

Meloxicam is not prescribed for "Aspirin" triad   (intolerance to drugs pirazolonovogo series, acetylsalicylic acid, recurrent nasal polyposis, asthma). The drug does not apply to severe renal pathology system, breastfeeding, pregnancy, ulcerative lesions of the gastrointestinal tract, of drugs of the NSAID intolerance. Suppositories are not prescribed for diseases of the anal and rectum Department of inflammatory genesis. Elderly Meloxicam is prescribed with caution.

Side effects, overdose:

The digestive tract:   covert and overt gastrointestinal bleeding, erosive and ulcerative lesions of the digestive tract, improving liver enzymes , Epigastric pain, belching, nausea, vomiting, bloating, stool disorders such as constipation or diarrhea syndrome. Nervous system: hypersomnia , Headaches, dizziness. Bodies of blood: thrombocytopenia , Leukopenia, anemia. Allergic reactions such as blisters , Skin rash, itching. Cardiovascular system:   heartbeat, "flushing" of blood to the top of the chest, the skin of the neck and face, raising blood pressure. Urinary system: increase in urea hypercreatininemia And swelling. Rarely recorded renal medullary necrosis, glomerulonephritis, interstitial nephritis, nephrotic syndrome. Chance of ringing in the ears. In overdose recorded increased severity of the above side effects. Timely posindromnaya therapy, gastric lavage. A specific antidote and antagonists have not been developed.

Mode of application:

Meloxicam is taken with food, inside. The daily dosage of 7 mg of 5-15. For patients on hemodialysis, the pathology of the renal system recommended dosage is 7, 5 mg. Rectal suppositories are administered 1 time per day (1 candle - 15 mg).

Special instructions:

Meloxicam cancel the development of side effects from the mucous membranes of the skin, the development of gastrointestinal bleeding , In case of peptic ulcers. In patients with reduced glomerular filtration rate (after surgical treatment, nephrotic syndrome, cirrhosis, congestive heart failure, dehydration On treatment with diuretics), with reduced BCC says the development of the clinical picture of chronic renal failure, which is reversible and disappears after completion of therapy. Such patients should be carried out daily monitoring of renal function, diuresis. When persistent and pronounced changes in the performance of the system hepatic drug cancel, hold special diagnostic tests. Patients at risk of meloxicam administered in minimal dose 7. 5 mg. The drug can affect driving, the performance of certain types of work.

Drug Interactions:

Myelotoxic medicines   cause increased severity gematotoksichnosti meloxicam. Simultaneous treatment with other drugs of the NSAID the risk of gastrointestinal bleeding and erosive and ulcerative lesions increases considerably. Kolestiramin promotes rapid clearance of the drug metabolites. Heparin, ticlopidine,   indirect anticoagulants , Antihypertensive drugs increase the risk of bleeding. Nephrotoxic effect of increases cyclosporine .