Midantan

Description overdue on 12.07.2012

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Antiparkinsonian   with antiviral activity. The main component of amantadine is simmetirichnym, tricyclic adamantamine . The mechanism of action is based on blocking NMDA-glutamate receptor (also substantia nigra ), Thus reducing over-expressed stimulating effect of glutamate on cortical neurons neostimatum Which is formed when there is insufficient production of dopamine. Under the action of the drug delivery decreases ionized calcium ions into neurons, thereby reducing the risk of degradation. Midantan mostly affects bradykinesia, rigidity , Stiffness. Medicament reduces the penetration of the influenza virus type A into the cell. Midantan available in tablet dosage form, in solution form.

Indications, contraindications:

Midantan prescribed for Parkinson's syndrome , With Parkinson's disease, influenza A (treatment, prevention, combined with vaccination) with neuralgia Caused by herpes zoster (the causative agent of Varicella zoster).

Midantan does not apply in case of intolerance amantadine, angle-closure glaucoma, with epilepsy , Renal pathology system in thyrotoxicosis , A history of psychosis, with hypotension, prostatic hyperplasia, in the first trimester of pregnancy, when delirious psychosis, preddelirii, a state of excitement at CHF 2-3 degrees, breastfeeding, concomitant use of hydrochlorothiazide, triamterene. At allergic dermatitis , Orthostatic hypotension, alcoholism, elderly persons, for mental disorders Midantan used with caution.

Side effect:

Urinary Tract: nocturia, polyuria , Acute urinary retention in patients with benign prostatic hyperplasia. Nervous system:   irritability, dizziness, headaches, mental disorders, heteroptics , Seizures, mental stimulation, headache, motor excitation. Cardiovascular system: tachycardia , Worsening of heart failure, arrhythmogenic effects, orthostatic hypotension . Digestive system:   dyspepsia, dry mouth, disturbances of appetite, nausea. It is also possible to develop dermatosis , Alleviation of visual perception, color of the skin of the upper and lower limbs in the bluish tint.

Mode of application:

Midantan taken after meals, inside .  The starting dosage for Parkinson's disease is 100 mg per day, the interval between doses - 6 hours, the last daily dose is taken before dinner, therapy - 3 days .  Further, from 4 to 7 days to increase the amount of amantadine 200 mg per day, following two weeks of taking the drug at a dose of 300 mg per day .  Further dosage is carried out depending on the patient: 300-400 mg per day .  The maximum daily dose - 600 mg .  Midantan administered intravenously at 200 mg three times daily, infusion duration - 3 hours, the rate of infusion - 55 drops per minute .  The course of treatment Midantan - 5-7 days .  In the pathology of renal systems increase the interval between doses, the dosage is reduced .  Treatment of neuralgia caused by Varicella zoster: 1-2 intravenous infusion, the rate of 14-17 days .  Podilym patients to reduce the dose of medication is recommended .  Prevention, treatment of influenza: tablet form 200 mg per day, the course of 10 days .  Children appoint not more than 150 mg per day .

Special instructions:

The data on the effectiveness of the drug in the treatment of extrapyramidal disorders during therapy with antipsychotic drugs ( Parkinson's drug ) Are inconsistent. Unacceptable abrupt withdrawal of medication Midantan because of the risk of exacerbation. In patients with peripheral circulatory disorders, heart failure need regular medical examination. Absolutely contraindicated use of ethanol. Midantan affect the control of vehicles.

Drug Interactions:

Ethanol drugs that stimulate the central nervous system, increase the likelihood of side effects. Midantan improves   psychostimulants , Levodopa. Drug compatible with other antiparkinsonian drugs, with the central holinoblokatorami .