Description overdue on 11/13/2014
- Latin name: Ceforal Solutab
- ATC code: J01DD08
- Active substance: Cefixime (Cefixime)
- Manufacturer: Astellas Pharma Europe BV, Netherlands
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Tseforal Soljutab (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One tablet contains: cefixime trihydrate 447, 7 mg (in terms of cefixime - 400 mg) plus excipients (low substituted giproloza, silica, strawberry flavor, microcrystalline cellulose, povidone, calcium saccharinate triseskvigidrat, E110, magnesium stearate).
Product form
The drug release in the form of oblong tablets dispersible With a characteristic smell of strawberries. Color - bright orange. Each tablet on one side of risk. In packs of 1, 5, 7 or 10 pieces.
Pharmacological action
Antibacterial, bactericidal means.
Pharmacodynamics and pharmacokinetics
Active substance - antibiotic It refers to the group cephalosporins third generation.
The mechanism of action is based on the ability to disrupt the synthesis process peptidoglycan Which is the main structural component of the cell walls of harmful microorganisms. Antibiotic resistant Beta-lactamase Exhibits bactericidal activity against a variety of Gram-positive and negative bacteria.
In the context of clinical trials, the drug was active in Streptococcus pneumoniae, Haemophilus influenzae, Escherichia coli, Neisseria gonorrhoeae, Streptococcus pyogene, Moraxella (Branhamella) catarrhalis, Proteus mirabilis .
Gram-positive bacteria perishing under the influence of the drug: Streptococcus pneumoniae and Streptococcus agalactiae . Gram - Citrobacter amalonaticus, Neisseria gonorrhoeae, Haemophilus influenzae, Escherichia coli, Proteus vulgaris, Klebsiella oxytoca, Providencia spp., Citrobacter diversus., Shigella spp., Moraxella catarrhalis, Haemophilus parainfluenzae, Proteus mirabilis, Klebsiella pneumoniae, Pasteurella multocida, Salmonella spp .
However, medication is not capable of withstanding: Pseudomonas spp., Enterobacter spp., Listeria monocytogenes, Serratia, Bacteroides fragilis, Clostridium spp., Enterococcus spp., Staphylococcus .
After receiving the money into about half the active substance is absorbed through GI . If the drug is taken together with food, while Absorption It increased by approximately 0 8:00. After 2-6 hours, the antibiotic concentration in serum is approaching 65%. Almost half of the substances excreted by the kidneys during the day. The half-life from plasma is between 3 and 5 to 9 hours.
It should be noted that elderly equilibrium value AUC 40% higher than the other groups of patients.
People suffering from kidney disease, if Cl creatinine up to 30 ml per minute, the half-life of tools is increased to 6 hours. Unless Cl creatinine 6-20 mL per minute - up to 11 hours and a half.
Indications
The drug is used to treat infectious and inflammatory diseases caused by susceptible antibiotic microorganisms:
- infection Otolaryngology and respiratory ;
- if the island is not complicated gonorrhea ;
- for the treatment of chronic or acute urinary tract infections .
Contraindications
The drug is contraindicated:
- sick porphyria ;
- at allergies on cefixime ( penicillins, cephalosporins ), Or other components of the product;
- at allergies in step history . hives or rash on the skin;
- at asthma .
Side effects
Perhaps the manifestation of the following side effects of the drug:
- agranulocytosis, thrombocytopenia, eosinophilia, transient leukopenia ;
- hemolytic anemia . erythema . Stevens-Johnson syndrome , Fever, epidermal necrolysis ;
- bleeding disorders;
- level increase liver enzymes ;
- allergy . itching . hives . Lyell's syndrome (there is a need for an immediate lifting of the drug);
- dystrophy , Nausea, headache , Loss of consciousness, weakness;
- pain epigastric . indigestion and digestive disorders, vomiting, diarrhea . flatulence ;
- hepatitis or jaundice ;
- vaginitis . candidiasis Itching in the genital area.
Instructions for use Tseforal Soljutab (method and dosage)
The duration of treatment and dosage should be determined by a physician. After the onset of improvement in the condition, you must continue taking 2-3 days.
The tablet can drink a whole with plenty of liquid or dissolved in water. After dissolving in a liquid medicine to drink as soon as possible. The drug can be taken without regard to food.
Instructions on Tseforal Soljutab 400 mg, for children from 12 years and adults (body weight above 50 kg).
The daily dosage is usually at 0, 4 grams. It is possible to take one 400 mg tablet once or divided into 2 doses.
The course of treatment is 7 to 10 days.
For the treatment of uncomplicated forms gonorrhea You can take one tablet (400 mg) once.
For children up to 12 years the daily dosage is calculated by means of formula 8 mg per kg body weight of the child. Preparation drink 1 time per day or 4 mg per 1 kg body weight, every 12 hours.
If the disease is caused by a bacterium Streptococcus pyogenes , Duration of administration should not be less than 10 days.
For elderly patients dosage adjustment is required.
When kidney disease if KK It is 21-60 ml per minute, or the patient is on hemodialysis , The daily dose was reduced to 75% of the recommended. Unless KK less than 20 ml per minute, or the patient is on peritoneal dialysis , The daily dosage is reduced by half.
Overdose
If the amount of the drug taken, considerably exceeding the maximum daily dosage may increase the frequency of side reactions.
It should produce gastric lavage, supportive and symptomatic therapy. The drug has no specific antidote . hemodialysis and peritoneal dialysis ineffective.
Cooperation
Probenecid blockers or other secretion kanaltsievoy increases the concentration of antibiotic in blood and slows its removal, which could result in overdose.
Under the influence of the drug may increase the concentration carbamazepine in blood. When combined with the drug carbamazepine should monitor blood levels of the latter drug.
Aminoglycosides and Furosemide when taken with Tseforalom increase the load on the kidneys.
Precautions to combine medication with salicylic acid and nifedipine .
When passing Coombs test and antibiotics - cephalosporins It may appear a false positive result on the test.
The process of assimilation (absorption in GI ) cefixime It can be slow antacids Containing aluminum hydroxide or Magnesium .
The combination of the drug with anticoagulants or warfarin may increase prothrombin index , But clinical manifestations of bleeding is usually not occur.
Test results on the content Glucose in the urine (As for the test tablets copper sulfate . Fehling's solution or Benedict ) Are not valid if the patients received their holding Tseforal.
Under the action of the antibiotic can decrease the effectiveness of therapy with estrogen , Combined oral contraceptives .
Terms of sale
Prescription.
Storage conditions
At a temperature of not more than 25 degrees, not given to children.
Shelf life
3 years.
Cautions
For children under the age of 6 months, caution should be exercised in the treatment agent.
The tablets dissolved in water only.
Chronic administration of the drug interferes with the normal intestinal microflora may occur candidiasis oral mucosa, the growth of Clostridium difficile . diarrhea . pseudomembranous colitis .
If there is a strong allergic reaction an antibiotic, its reception should be stopped immediately.
In the application of the elderly should be careful.
Analogs Tseforal Soljutab
Cefixime
Pantsef
Klaforan
Cefodox
Supraks Soljutab
Ceftriaxone
Close analogues Tseforala: Lopraks, Supraks Soljutab, Flamifiks, Sortsef, Cefixime, Ikzyme, Vinex, cefixime .
During pregnancy and lactation
To date there is no experience in the application of sufficient funds in pregnant women. Because the drug appoint only when strictly necessary, only after consultation with your doctor.
Breastfeeding while taking the antibiotic should be discontinued.
Reviews Tseforal Soljutab
Most reviews are good. Many write, it's just a miracle drug, due to its wide range of applications. Men are particularly pleased with the fact that the drug is rapidly (1 reception!) Relieves gonorrhea .
There is positive feedback when Tseforale cystitis . One woman for a long time, almost a year trying to cure cystitis , But the disease came back after a while. A Tseforal "immediately helped."
Quite often there are side effects usually associated with digestive problems and hypersensitivity reactions.
Price Tseforal Soljutab
Price Tseforala ranges from 500 to 800 rubles for 7 tablets.
Buy in Moscow can be a cure for around 630 rubles (7 pieces of 400 mg).
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