Co-Renitec

Description overdue on 10/26/2014

• Latin name: Co-Renitec
• ATC code: C09BA02
• Active substance: Enalapril maleate (Enalaprili maleates), hydrochlorothiazide (Hydrochlorothiazide)
• Manufacturer: Merck Sharp & Dohme B.V. (Netherlands)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Co-Renitec (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

Co-Renitec contain active ingredients such as enalapril maleate   and hydrochlorothiazide . Furthermore, it has additional components such as dye yellow iron oxide . pregelatinized corn starch . corn starch . lactose, water . Sodium Bicarbonate . magnesium stearate .

Product form

The medicine is available in tablets which are in the blisters contained therein.

Pharmacological action

The drug is ACE inhibitor   and diuretic .

Pharmacodynamics and pharmacokinetics

The medicament reduces the sodium ions in the vascular wall, arterial pressure , The tone of blood vessels, PR As well as increases diuresis . The antihypertensive effect lasts for days.

Thus, the drug is effective in the case of hypertension . Antihypertensive   effect of the active drug components complement each other. Therapy data means more efficient in most cases, hypertension Than using enalapril maleate   and hydrochlorothiazide   separately.

Enalapril   It is ACE inhibitor . After Absorption   he metabolized   at enalaprilat . Its action reduces the level Angiotensin II   in plasma, because of which the activity is increased Renin   blood plasma and reduced   secretion aldosterone . Besides that, enalapril   prevents destruction bradykinin .

Reduction Blood Pressure accompanied by a reduction in total peripheral vascular resistance and a slight increase cardiac output.   The drug increases renal blood flow . This does not change the speed glomerular filtration rate Unless patients it was not initially lowered.

Hydrochlorothiazide   It is diuretic   and antihypertensive   a tool that enhances the activity Renin . Thus, in combination with enalapril   it leads to a significant reduction Blood Pressure . Cancel the drug does not cause him a sharp rise.

The maximum effect usually appears after 2-4 hours after application. Antihypertensive   the effect is visible within an hour. The duration of the drug depends on the dosage. It generally lasts throughout the day.

Indications

The tool shown in the hypertension If it considered the most effective combination therapy.

Contraindications

Do not use Co-Renitec at hypersensitivity   to its components, childhood . anurii . angioedema   at history , and hereditary   or   idiopathic angioedema .

The caution is indicated for the tool:

• bilateral   renal artery stenosis ;
• coronary heart disease ;
• aortic stenosis ;
• severe systemic connective tissue diseases;
• diabetes ;
• condition after kidney transplantation;
• with limited dietary sodium;
• the elderly;
• cerebrovascular   diseases;
• Chronic Heart Failure ;
• renal failure ;
• suppression of bone marrow hematopoiesis;
• states that are associated with a decrease in blood volume;
• hepatic insufficiency ;
• hyperkalemia ;
• artery stenosis of a solitary kidney .

Side effects

The negative side effects, according to research, as a rule, are moderate. Usually they do not need treatment withdrawal. Side effects may include:

• respiratory system - the appearance of shortness of breath, cough;
• CCC - palpitations, orthostatic   effects, fainting, hypotension , chest pain, tachycardia ;
• musculoskeletal system - the appearance of muscle cramps, pain in the joints;
• Kidney - Development renal failure Problems with the kidney function;
• laboratory parameters - hyperglycemia . hyperkalemia . hypokalemia . hyperuricemia , Reduction hematocrit   and Hemoglobin ;
• CNS - dizziness , Irritability, asthenia . paresthesia , Fatigue, drowsiness . headache . sleep disorders ;
• digestive system - dyspepsia . diarrhea , Nausea, flatulence , Dry mouth, vomiting, abdominal pain, constipation . pancreatitis ;
• allergy - itch Rash;
• reproductive system - Development Impotence , Decreased libido;
• Other - tinnitus, gout .

In addition, in rare cases, when taking medication are possible undesirable effects as angioedema   glottis, limbs, tongue, face, larynx, lips, Stevens-Johnson syndrome . intestinal angioedema . hyperhidrosis .

Instructions for use Co-Renitec (method and dosage)

This tool is used orally   on a tablet once a day. If necessary, the dosage may be increased to two tablets per day.

Instructions for use Co-Renitec is recommended to control the data of water and electrolyte balance. If the patient has previously received diuretics , You need to wait 2-3 days before use tablets Co-Renitec. In cases where there is an increase urea   and creatinine   Blood applying means should stop.

Overdose

At reception enalapril in high doses may significantly decrease Blood Pressure   (approximately 6 hours after consumption) and stupor. Overdose hydrochlorothiazide   It can lead to an imbalance of electrolytes and dehydration   due to excessive diuresis.

Cooperation

Ko Renitek can be applied to other antihypertensive   drugs. Then there is the summation of action. In combination with the additives of potassium, potassium-sparing and potassium-salts diuretics   likely hyperkalemia .

The interaction with lithium reduced excretion of lithium by the kidneys. Increases the likelihood of lithium intoxication .

NSAIDs   reduce the effect of the medicine. And if they accept patients with renal problems, this combination may lead to a deterioration of the kidneys. But these changes are reversible.

Antihypertensive   reduce the effect of the drug Estrogens   and ethanol . Immunosuppressive . cytostatics   and Allopurinol   increase the likelihood of gematotoksichnosti .

Terms of sale

This tool is sold by prescription.

Storage conditions

Temperature - 30 ° C. Store this medication should be in a dry place.

Shelf life

Three years.

Analogs Co-Renitec

Match code ATC 4th level:

• N Hart
• Hart Dr.
• Noliprel
• Co-Perineva
• Kaptopres

Analogs Co-Renitec sold in pharmacies as follows:

• Enalapril-HL-Health ;
• Berlipril Plus ;
• Aisne Sandoz Compositum ;
• Enalapril-H-Health ;
• Enalozid ;
• Enalozid Forte ;
• Enap-H ;
• Enap-HL ;
• Enapril-H .

Reviews on Koh Renitek

Reviews on Koh Renitek demonstrate its effectiveness. Adverse reactions reported rarely. Patients generally say that side effects go away and do not require discontinuation of treatment.

Price Co-Renitec where to buy

Price Co-Renitec, in a package of 28 tablets which, on average, about 340 rubles.

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