Description overdue on 10/13/2014
- Latin name: Rulid
- ATC code: J01FA06
- Active substance: Roxithromycin (Roxithromycin)
- Manufacturer: SANOFI AVENTIS (France)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
1 tablet contains 150 mg roxithromycin . Auxiliary components: colloidal silicon dioxide, povidone K30, poloxamer giproloza, talc, magnesium stearate, corn starch.
The shell consists of titanium dioxide, dextrose, propylene glycol and hypromellose.
Product form
Tablets special membrane shell packed into blisters. Each tablet engraved "164". The carton box is 1 blister.
Pharmacological action
Roxithromycin is antibiotic from the group macrolides . The active component has a broad spectrum of antimicrobial activity. High doses of bactericidal effect on microorganisms. In tablets low toxicity.
The drug acts on:
- chlamydia;
- staphylococci;
- Listeria;
- Legionella;
- meningococcus;
- diphtheria;
- mycoplasma;
- streptococci.
In regard to ureaplasmas and Haemophilus influenzae recorded a moderate sensitivity. Fuzobakterii, aktinebakterii, Pseudomonas and Enterobacteriaceae resistant to roxithromycin.
Pharmacodynamics and pharmacokinetics
Resorption rate is independent of food intake. The active substance is absorbed through the ¼ hour after administration per os. With twice daily dosing, effective concentrations are saved 1 day. Active component easily penetrates into the tissue of the prostate, lung, tonsils.
The kidneys and intestines output ½ roxithromycin in its original form (partial metabolism ).
Indications
The antibiotic prescribed for infectious lesions.
Respiratory system:
- pneumonia (atypical flowing form);
- pharyngitis (acute stage);
- bronchitis;
- Sinusitis (sinus disease);
- tonsillitis.
The drug is prescribed for diseases of the urinary tract, including sexually transmitted with the exception of gonorrhea . The medicament used for prophylaxis Meningococcal meningitis patients exposed to sick. The drug is effective in infectious diseases of the skin and the accompanying soft tissue.
Contraindications
- Treatment dihydroergotamine, ergotamine;
- lactation ;
- Individual hypersensitivity ;
- pregnancy ;
- age 2 months.
Side effects
- epigastric pain;
- bronchospasm;
- angioedema;
- nausea;
- weakness;
- migraine headache ;
- paresthesia;
- dizziness ;
- rash;
- cholestatic hepatitis (acute form);
- anaphylaxis ;
- superimposed infection ;
- uritikariya ;
- diarrhea ;
- perversion of taste perception.
In case of other adverse reactions is recommended medical care and discontinuation Rulid.
Instructions for use (method and dosage)
A single dose is taken every 12 hours. For children over 40 kg and adults the single dose is 300 mg. Some doctors used the treatment regimen where the drug is used 1 time a day at a dose of 300 mg.
Instructions for use in pathology rulid renal system: 1 time a day at 150 mg, the duration of treatment is not less than 5 days.
The attending doctor evaluates the effectiveness of antimicrobial therapy roxithromycin, determines the severity of adverse events, conducting appropriate tests, and then adjusts the treatment regimen.
Overdose
Record the increased severity of adverse reactions. Specific antidote It has not been developed. Recommended emergency gastric lavage to remove residual drug and prevent absorption. Effectively appointment enterosorbents .
Cooperation
Perhaps the development of Arrhythmia when concurrent therapy cisapride, astemizole, pimozide because competition roxithromycin and medicaments for the above SYR isoenzyme 3A. Efficiency is enhanced by rulid receiving midazolam, Digoxin . Cyclosporine , Disopyramide, Theophylline .
Roxithromycin and other macrolide antibiotics enhance concentration terfenadine That can cause serious ventricular arrhythmias.
At reception vitamin K antagonist required level of change control INR and prothrombin index .
Terms of sale
Prescription drugs.
Storage conditions
Required temperature range - up to 25 degrees. Tablets reach of children.
Shelf life
3 years.
Cautions
Patients with abnormal renal system and liver diseases, dose selection is carried out on an individual basis, assessing the performance of laboratory tests, general health and comorbidities.
Analogs rulid (substitutes)
Klatsid
Klatsid CP
Klabaks
Fromilid
Azitroks
Hemomitsin
Vilprafen
Rovamycinum
Roxithromycin
Clarithromycin
Azithromycin
Midecamycin
Sumamed
- Hydroxide;
- Brilid;
- Ksitrotsin;
- Esparoksi.
Rulid and its analogues have the same number of roxithromycin - 150 mg, but differ in price, manufacturer and quality, so the choice of medication provides the attending physician. Not recommended replacing self rulid structural analogues.
During pregnancy (and lactation)
Rulid contraindicated in pregnancy . It requires termination breast-feeding during antibiotic therapy, because of the active substance passes into breast milk.
Reviews rulid (opinion of doctors and patients)
Attending physicians are using the medication in cases where developed a microbial resistance to essential antibiotics. Patients leave only positive feedback about rulid on the internet, pointing to the good tolerability, the lack of strong negative reactions during treatment and high efficiency in the first days of treatment.
Price rulid where to buy
The cost of antibiotic varies from 750 to 1000 rubles. Price rulid in Moscow is 910 rubles. The Internet pharmacy drug costs less - 750 rubles.
No comments:
Post a Comment