A breakthrough in the treatment of Alzheimer's disease and Parkinson's!

Researchers from the Institute of Biotechnology of Manchester have made a breakthrough in the search for drugs against degenerative diseases such as Parkinson's disease and Huntington's chorea. In the near future, their discovery could be used as the basis for the creation of new effective drugs yet incurable diseases.

Scientists have discovered an enzyme in the brain that is inhibited (ie, suppressed) by a special drug component created for the treatment of Huntington's chorea. It's about an enzyme called kynurenine 3-monooxygenase (CMO), are formed in the human brain in a natural way.

Scientists took five years to fully install the entire crystal structure of the enzyme. They then studied as a component of UPF 648 binds to the enzyme acting as an inhibitor. Previous studies in animal models neurodegenerative diseases   It showed that the "off" the enzyme activity by 648 UPF should be an effective treatment of neurodegenerative disorders.

"UPF 648 works perfectly as an inhibitor of the enzyme activity, - says study leader Professor Nigel Skratton. - However, in its current form this component, unfortunately, does not go to the brain through the blood. Now we are trying to find similarities in structure components that could not only inhibit the enzyme, but also take place in the brain. "

According to Professor Skrattona, this line of research promises a long-awaited creation of drugs that would have spared humanity Alzheimer's disease . Parkinson   and Huntington's chorea As well as many other neurodegenerative diseases. However, according to the most optimistic estimates, the new drugs (if successful researchers) will be able to enter the market no earlier than 10 years. (READ MORE)

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