Altevir

Description overdue on 08/19/2014

• Latin name: Altevir
• ATC code: L03AB05
• Active substance: Interferon alfa-2b, recombinant human (Interferon alfa-2b human recombinant)
• Manufacturer: Pharmapark (Russia)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Altevir
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Reviews
• Price, where to buy

Composition

The solution contains as an active ingredient interferon alfa-2b, recombinant human And such additional components as sodium acetate . ethylenediaminetetraacetic acid disodium salt Dextran 40, sodium chloride, purified water for injection, Tween 80.

Product form

The drug is produced as a solution for injection.

Pharmacological action

The drug has antiviral . antiproliferative . immunomodulatory   and antitumor properties .

Pharmacodynamics and pharmacokinetics

The active ingredient of the drug interacts with cell-surface receptors by initiating complex chain of transformations (e.g., induction of the synthesis of   Cytokine   and enzymes ), And inhibits the synthesis of viral RNA and viral proteins. This causes antiviral   and antiproliferative   effects of the drug.

In addition, the active substance activates presentation Altevira antigen to immunocompetent cells . It also stimulates the cytotoxic effect T cells   and phagocytic activity macrophages It inhibits the synthesis of some oncogenes   and inhibits cell proliferation, including cancer.

The bioavailability of the drug - about 90%. Half-life of 2-6 hours. The drug is eliminated via the kidneys through glomerular filtration rate . After 16-24 hours the active substance in the blood is not determined. Cleaved in the liver.

Indications

The drug is used for:

• hairy cell leukemia ;
• chronic Viral hepatitis AT   (if not cirrhosis   and signs);
• Non-Hodgkin lymphoma ;
• laryngeal papillomatosis ;
• Multiple Myeloma ;
• genital warts ;
• progressive kidney cancer ;
• chronic viral hepatitis C   (if there is no liver failure and its symptoms) - is attached to the complex therapy Ribavirin ;
• chronic myeloid leukemia ;
• melanoma ;
• Kaposi's sarcoma   at AIDS .

Contraindications

Altevir does not apply to:

• hypersensitivity to the drug;
• heavy renal failure ;
• chronic hepatitis   decompensated cirrhosis of the liver ;
• taking immunosuppressive drugs;
• decompensated pulmonary disease;
• hypercoagulable ;
• heavy hepatic insufficiency ;
• pregnancy ;
• Lactation ;
• severe cardiovascular diseases;
• serious disturbances in the central nervous system (especially in the case of epilepsy . depression );
• autoimmune diseases ;
• decompensated diabetes ;
• expressed mielosupression .

Side effects Altevira

Altevira side effects often manifest themselves as fever . headache , Chills, nausea , General weakness, myalgia , Blunting appetite.

In addition, possible vomiting arthralgia . drowsiness , Dry mouth, depression , Malaise, taste alteration, insomnia . diarrhea , Suicide attempts, asthenia . dizziness . alopecia , Increased sweating, irritability, decreased Blood Pressure .

In rare cases, pain in the stomach, nervousness, anxiety, dyspepsia . autoimmune thyroiditis . There may be changes in laboratory parameters (reversible): leukopenia , Reducing the level Hemoglobin , Elevated liver enzymes, granulocytopenia . thrombocytopenia .

Instructions on Altevir

The drug is administered intramuscularly, intravenously, intraperitoneally, subcutaneously, intrathecal, intralesional. Instructions on Altevir provides the following single dose for adults - 3-6 million IU. If necessary, it can be increased. Children appoint 500-100 thousand. IU per kilogram.

Depending on the disease user application also provides the following regimen:

• laryngeal papillomatosis   - Adult 6 million IU 5 times in 7 days, or 3-6 million IU three times in the last 7 days (a course of treatment - a month), 3 million IU twice in the last 7 days (a course of treatment - 12 weeks), 3 million IU every 7 days (a course of treatment - 28 weeks); children 50-100 thousand. IU three times in the last 7 days (a course of treatment - a month), 50 thousand. IU every 7 days (a course of treatment - 28 weeks), 50 thousand. IU twice in the last 7 days (a course of treatment - 12 weeks ). In the case of disease progression dosage may be increased;
• heavy hepatic failure   have babies - 3-6 million IU / m doctor prescribes intraperitoneally during the week, the following day. During the second week of treatment, the same dose administered intramuscularly. Receiving frequency may be reduced to three times a week from the third week;
• chronic hepatitis B   - Specialists in adult patients recommend taking 6 million IU intramuscularly for two weeks every day, then twice in the last 7 days (a course of treatment - 16 weeks) and three times in the last 7 days (a course of treatment - a month); children under 12 must be taken 3-6 million IU / m intramuscularly three times in the last 7 days (a course of treatment - 16 weeks); children under the age of 12 years take a single dose of 6 million IU;
• chronic hepatitis C   - Experts point to use for adult patients 3 million IU by subcutaneous or intramuscular injection three times in the last 7 days (treatment - 9 months), children should take 3 million IU / m in the same way;
• HIV infection   - You need to take 3 million IU three times in the last 7 days. If there neutralizing antibody preparation replaced natural interferon;
• dengue fever   - Taken within 72 hours after onset of symptoms, the adult prescribe take 3-6 million IU 3 days every day, children take 50-100 thousand. IU per kilogram of body weight in the same way;
• non-Hodgkin lymphoma   (malignant medium or low) - the drug is taken after a remission, which is achieved by chemotherapy . It should be administered 6 million IU three times in the last 7 days;
• genital warts   - Adult patients should be administered 6 million IU (the whole course of treatment is designed for 6 weeks) daily in conjunction with interferon alpha-2b   (ointment) three times each day, patients in childhood appointed by 50-100 thousand. IU per kilogram;
• viral hepatitis   - First 12-15 MIU (used to be - 3-5 days) intramuscularly or intraperitoneally daily, then to 6 million IU by intramuscular injection a day, pending the negative results regarding viral markers hepatitis ; in the case of subacute viral hepatitis   childhood after 1 year must be taken 3-6 million IU / m 1-2 weeks (first week intraperitoneally, intramuscularly later), then the treatment can be continued with the same dose, but three times within 7 days until the negative indicators markers of disease;
• Kaposi's sarcoma   - Appoint 30 million IU daily for a reception, with early diagnosis - 6 million IU (used to be - 6 weeks) daily, the same dose administered to children;
• chronic myelogenous leukemia   - After remission   take 3 million IU / m through the day before cytogenetic remission   or regression of the disease;
• herpes zoster   - Doctors recommend the use of 6 million IU (course of treatment - a week) on a daily basis, then, if necessary, take the 6 million IU a day for two weeks. Should be combined with interferon alpha-2b   (as an ointment) every 6 hours;
• solid tumors   - Adult patients should be 9 million IU by injection subcutaneously or intramuscularly for a month every day, maintenance dose - 6 million IU three times in the last 7 days (a course of treatment - 3 months), children should be introduced 3-6 million IU / sq. m in the same regimen. If the effect is positive, treatment can stretch for a year in maintenance dose.

In some cases, the treatment regimen may vary. Maximum dosage in this case should not exceed 3 million IU.

Overdose

As regards overdoses Altevire data is not available.

Cooperation

Possible reactions to the combination Altevira with other drugs has not been fully explored. Precautions This medication should be taken with hypnotics   and sedatives As well as those that have myelosuppressive effect And narcotic analgesics .

When used in conjunction with Altevir Theophylline , It is necessary to observe the concentration in the blood, the dosage can be adjusted.

The combination of the drug with chemotherapy anticancer drugs   increases the risk of toxic effects.

Terms of sale

The drug is released in pharmacies with a prescription.

Storage conditions

Store the medicament need at about 2-8 ° C, in any case should not be frozen. The location must not be accessible to children.

Shelf life

Keep the medication should be no longer than 18 months.

Reviews Altevire

Reviews Altevire indicate that many patients tolerate the drug is hard enough. Very often, a forum in which to discuss the tool, contains messages about the appearance of side effects. Despite this Altevire reviews mostly positive, many patients complain of negative effects, but note the obvious effectiveness of this tool.

Price Altevira where to buy

Buy Altevir 3 million IU   or 5 million IU   It can be in Russian pharmacies are strictly on prescription. This tool is quite expensive. Price Altevira 3 million IU - about 1100 rubles. The ampoules of 5 million IU of the drug can be bought on average for 1500 rubles.

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