Description overdue on 11/14/2014
- Latin name: Flucostat
- ATC code: J02AC01
- Active substance: Fluconazole (Fluconazole)
- Manufacturer: Pharmstandard-Leksredstva (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Flucostat, instructions for use (method and dosage)
- Overdose
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition fljukostat
Composition 1 ml solution for parenteral administration:
- fluconazole - 2 mg;
- sodium chloride;
- water for injections.
Capsule Fljukostat has the following components:
- Fluconazole - 50 mg (or 150 mg);
- colloidal silicon dioxide (Aerosil);
- corn starch;
- magnesium stearate;
- sodium lauryl sulfate;
- lactose.
Shell capsules It comprises:
- gelatin;
- iron oxide red dye (E 172);
- methyl parahydroxybenzoate;
- Propyl;
- titanium dioxide (E 171);
- acetic acid.
Product form
- Coated capsules pink or light pink-brown, opaque. Inside is a powder of white or close to white color. Packed by 7 pieces in contour cell blisters. Cardboard packaging can hold one record.
- Pills 50 or 150 mg of a white, oval-shaped in contour-curable acheikova blister 1 or 2. A cardboard package comprises only one plate of the drug.
- A solution for intravenous administration as a clear, colorless liquid in bottles of 50 ml. The carton is put 1 bottle with the drug.
- Vaginal suppositories oval white that are packed into blisters with aluminum foil, or PVC.
Pharmacological action
Flucostat - strong antifungal a pharmaceutical preparation which in the chemical structure belongs to the class of triazole compounds. It is active against the following microorganisms families:
- Candida spp;
- Cryptococcus neoformans;
- Microsporum spp;
- Trichpphuton spp;
- Blastomyces dermatidis;
- Coccidioides immits;
- Histoplasma capsulatum.
Mechanism therapeutic drug effect is the ability of a biologically active component to selectively inhibit the synthesis of sterols cells sensitive fungi, whereby cell wall malicious or conditionally pathogenic microorganisms becomes unsound As sterol is one of its main components.
Pharmacodynamics and pharmacokinetics
After oral receiving tablets or capsules, the active current components are well absorbed in the gastrointestinal tract. Even at 0, 5-1, 5:00 fasting reaches maximum plasma concentration. The constituent elements of the drug penetrates well into all body fluids . There are certain properties to the cumulation - six months after the completion of the conservative therapy Fluconazole can be found in the nails. About 80% of the metabolites of the pharmaceutical preparation is eliminated by the kidneys.
With Intravenous parenteral solution administration fljukostat active ingredients are evenly distributed in the biological fluids (concentration in lung sputum and saliva in the oral cavity corresponds to the number of fluconazole plasma). After several injection of 1 dose per day level equilibrium concentration It achieved the 4-5 day medical treatment, and at the initial application of the double amount of preparation - to 2 day.
In the bloodstream about 11-12% of the total number of Fluconazole binds to plasma proteins because of what half life It corresponds to 30 hours. Displays a pharmaceutical preparation in the vast majority (about 80%) in the urine. Clearance of the active component is directly proportional to creatinine clearance.
Indications
- cryptococcosis (including krikptokokkovy meningitis);
- chromophytosis ;
- generalized or disseminated candidiasis, predominantly affects the skin and mucous membranes (e.g., oral cavity and esophagus);
- deep endemic fungal infections (sporotrichosis, histoplasmosis, coccidioidomycosis);
- urogenital candidiasis in men (candidal balanitis) and women (vaginal candidiasis or thrush);
- prevention fungal infections in patients with acquired immunodeficiency syndrome;
- fungal infections various etiologies;
- defeat pathogenic fungi during cytostatic, chemotherapy or radiation therapy;
- onychomycosis .
Contraindications
Strict contraindications include the following states:
- increased individual sensitivity to the active component or excipients;
- glucose-galactose syndrome malabsorption;
- intolerance lactose (including lactase deficiency);
- inherited or acquired intolerance components of the pharmaceutical formulation;
- Children under 3 years of age;
- galactosemia ;
- fljukostat with the combined use of drugs that prolong the QT interval Electrocardiogram (particularly astemizole or terfenadine).
You should also outline the list of non-absolute contraindication, when the medicine should be used carefully (recommended passage of conservative therapy under the supervision of qualified medical staff):
- kidney or liver failure;
- alcoholism ;
- treatment of potentially hazardous pharmaceutical products with a high percentage hepatotoxicity ;
- proaritmogennoe state (particularly if the patient has multiple risk factors for arrhythmia).
Side effects
For oral use of capsules or tablets:
- From the digestive system: nausea, diarrhea, bloating and flatulence .
- Nervous system: headache and dizziness .
- From hemopoiesis system: thrombocytopenia, leukopenia, agranulocytosis .
- Allergic symptoms: anaphylactic reactions, skin rash .
Intravenous use of pharmaceutical formulation can exhibit the following side effects:
- From the gastrointestinal tract: nausea and following vomiting, flatulence, abdominal pain, functional liver failure (increased levels of alkaline phosphatase, serum transaminases or bilirubin).
- Nervous system: headache, seizures .
- Cardio-vascular system: prolongation of the QT interval . flicker or even flutter ventricles .
- Allergic reactions: skin rash, Stevens-Jonas , Toxic epidermal necrosis, or Lyell's syndrome (extreme manifestation toxicoderma ), Anaphylactic reactions.
- Metabolic processes: hypercholesterolemia, hypokalemia, hypertriglyceridemia.
- With other systems: alopecia, renal failure .
Flucostat, instructions for use (method and dosage)
Tablets Flucostat, instructions for use
Capsules, tablets and coated using enterally That is inside. Swallow should be whole, without compromising the integrity, this may affect the therapeutic efficacy of treatment. How to make - before or after meals - it does not matter, since absorption fljukostat active components does not depend on the filling of the lumen of the digestive tube. The duration of treatment is chosen individually, as a rule, conservative therapy is to complete negativatsii results of microbiological studies of pathological focus.
The dosage of the pharmaceutical preparation and treatment regimen depends on clinical diagnosis:
- atrophic oral candidiasis and similar infections of mucous membranes - 50-100 mg / day during days 14-30;
- cryptococcal infection . disseminated candidiasis and entering fungi in blood - Day 1 400 mg, followed by 200-400 mg 1 time per day for a long period;
- vaginal candidiasis and balanitis - 150 mg dose, and further to prevent the recurrence of 150 mg 1 time per month for 4-12 months;
- fungal infections of the skin - 150 mg 1 time per week or 50 mg 1 time per day for 2-6 weeks, depending on the susceptibility to treatment;
- chromophytosis - 1 50 mg once a day for 2-4 weeks;
- deep endemic mycoses - 200-400 mg per day (the length depends on the pathogenic fungi that cause disease);
- onychomycosis - 150 mg 1 time a week before full resumption of unaffected nail plate (on hand fingernails grow for 3-6 months, and on his feet - 6-12 months).
In order to increase the effectiveness of conservative treatment in the scheme of therapy is often added antibiotics . Especially widely used in this way was Soljutab - Beta-lactam penicillin Which is used to prevent the development of generalized infections by topical or general immunity reducing toxins of pathogenic fungal colonies. How to drink antibiotics should check with your doctor, because improper use can cause adverse effects such as goiter, or the development of resistance to the penicillin group of microflora drugs.
Antifungal drug for children
Fljukostat tablet form and can be used in pediatric practice, since fungal children develop and occur more frequently than in adults. Dosage selected individually for each child, based on its anthropometric parameters (eg weight) and a clinical diagnosis that should be confirmed by microscopic examination. The following regimens for pediatricians:
- mucosal candidiasis - 6 mg per 1 kg of body weight in one day, and then to 3 mg per kg to negativatsii results of microbiological studies;
- cryptococcosis and systemic candidiasis - 6-12 mg / kg, depending on the severity of the disease;
- prophylactically against decrease in immune capacity of the body - 3-12 mg per 1 kg of body weight per day (the exact amount of the pharmaceutical formulation should be calculated on the basis of leukopenia level in the blood).
How to drink the drug from yeast
How to receive from Flucostat thrush Each patient can decide on their own or find advice from a qualified professional, as there are different schemes of treatment of fungal infections of the urogenital region in women. The amount and frequency of application depends on the manifestation of the pathological process, forms of the disease and related complications:
- Uncomplicated candidiasis, emerged for the first time with mild or moderate symptoms - 1 capsule (150 mg fljukostat) once.
- Complicated form of thrush with symptomatic or with concomitant chronic diseases - 150 mg of the drug in the 1 and 4 day conservative therapy.
- Relapsing forms of candidiasis in women which appears at least four times during the year - 150 mg in three divided doses, at 1, 4 and 7 days of readjustment. You must also treat sexual partner - 150 mg dose. This form of fungal diseases require maintenance therapy to prevent recurrent episodes of the disease. For this purpose, tablets of 150 mg 1 time per week for 6 months.
How many assists pharmaceutical preparation
Does the cure for thrush and how long to wait for a therapeutic effect, can be found in two weeks a severe form of the disease or through week If the disease entities manifest mild symptoms without adverse effects, because it is so much usually lasts a course of conservative treatment, after which they disappear without a trace following symptoms:
- bothersome itch and burning in the vulva and vagina;
- abundant cheesy discharge ;
- pain during intercourse or urination.
Candles Flucostat
It should be noted that the instructions for use fljukostat with thrush may also include a candle as a local agent for controlling harmful fungi from the point of view of the medical community is much more beneficial for several reasons:
- the use of vaginal suppositories is not accompanied by discomfort or inconvenience;
- a course of conservative therapy can begin immediately since the discovery of the characteristic symptoms of this nosological unit, not even waiting for the end of the menstrual cycle;
- side effects treatment pharmaceutical agent developed less often ;
- therapeutic effectiveness of candles is not dependent on food intake, time of day and in no way affects the usual order of things.
To make sure how to take Flucostat for thrush in the form of candles, the exact dosage of the pharmaceutical form of the drug, duration of therapy, it is necessary to apply to the antenatal clinic or in the gynecological ward, however, as a rule, regimen It does not differ from that in the use forms enteralnoy antifungal drug.
Instructions on Flucostat for men
Thrush - a disease that affects mainly the female half of the population, but the widespread belief that the genitals exceptional candidiasis their destiny. It is erroneous. Of course, yeast fungi of the genus Candida bad take root in the urethra A strong part of our planet as a regular washed urine But the weakening of local immune mechanisms created favorable conditions for development urogenital candidiasis In connection with what is increasingly common question is whether to take the men Flucostat to eliminate yeast.
Pharmaceutical preparation antifungal Actions absorbed into the main bloodstream and spread evenly in biological fluids and media male body just as well as women. But biologically active components have no effect on hormones and are not capable of it as a change, because whether it is possible to drink men Flucostat to get rid of unpleasant diseases - of course, yes. Such therapeutic measures will be regarded as etiological therapy aimed at eradication of the causative agent of thrush.
Overdose
The symptoms observed with an overdose of the drug:
- hallucinations ;
- maximum manifestation side effects (see. the list above);
- paranoid behavior .
No specific antidote for the relief of pharmaceutical overdose fljukostat not. Gastric lavage should be carried out and symptomatic therapy individual manifestations. Also shown forced diuresis As the primary route of elimination of metabolites of the active ingredient - in the urine. Good manifests itself hemodialysis since three hours manipulating plasma fluconazole concentration is reduced by half.
Terms of sale
Abstract to a pharmaceutical preparation states that Flucostat in the pharmacy you can buy without a prescription, as the capsules and solution for parenteral administration is not listed among the potent and narcotic drugs.
Storage conditions
The drug should be stored out of reach of children under age category at a temperature of 15 to 25 degrees Celsius.
Shelf life
2 years
Cautions
Flucostat tends more lowering local immunity By acting in a specific way on the microflora of the urogenital area. Because of this adverse effect provides further gate for the invasion of infectious agents non-fungal nature, and thus create conditions for the development of unpleasant diseases of the genitourinary system. In order to eliminate the possible adverse effects of conservative therapy can be used antibiotics .
Qualified experts agree that should be used is not an ordinary pharmaceutical preparation, in order not to develop resistance to the main chemical constituents of drugs that act on harmful microflora. In this way it is often used Soljutab 30 , Reserve antibiotic from the above that the risk of complications of the treatment of fungal disease is reduced to nothing.
Analogs fljukostat
Diflyuzol
Rumikoz
Futsis
Vero Fluconazole
Kandizol
Kanditral
Itraconazole
Mikosist
Diflazon
Itrazol
Diflucan
Orungal
Mikomaks
Fluconazole
Irunine
Contraindications to the use fljukostat are common metabolic disorders, because there is a whole group of foreign pharmaceuticals, which under certain conditions can be used as an analogue fljukostat from yeast or other nosological unit of fungal origin. Mikosist, Mikomaks, Mikroflyukan We gained wide acceptance among patients, but it causes the greatest confidence Diflucan as a quality substitute for an antifungal drug.
Diflucan and Flucostat: the difference between the antifungals
- Diflucan - import a drug which is produced in such advanced countries as the United States and France, in contrast to domestic fljukostat;
- Flucostat - it original the drug appeared in the pharmaceutical market in the end of the last century;
- Flucostat contains certain chemical components that are not in Diflyukane.
Based on the differences between these pharmaceuticals to answer unequivocally, that better - Flucostat or Diflucan, - difficult. Credibility, of course, more developed at the foreign funds, especially in the production of large countries helps to ensure high quality of medicinal products. On the other hand the price fljukostat 10, and sometimes more times less than the cost of Diflucan that when our mindset is also highly valued, because the choice that the use - or Flucostat Diflucan should do yourself.
Domestic counterparts
As the price of analogues produced abroad, significantly higher than the price of domestic products, because patients try to avoid their acquisition and are increasingly trying to find cheap Russian analogues fljukostat.
Babies
- hypersensitivity
- hypertension
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