Afobazol

Description overdue on 09/20/2014

• Latin name: Aphobazolum
• ATC code: N05BX
• Active substance: Afobazol / Aphobazolum (morfolinoetiltioetoksibenzimidazola dihydrochloride / Morpholinoethylthioethoxybenzimidazolum dihydrochloride)
• Manufacturer: JSC "Pharmstandard", Russian Federation

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Afobazol
• Contraindications
• Side effects
• Instructions for use Afobazol
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition Afobazol

The composition includes Afobazol 5 or 10 mg Afobazol substance as an active ingredient and auxiliary ingredients:

• potato starch (Amylum solani);
• microcrystalline cellulose (Cellulose microcrystallic);
• milk sugar (Saccharum lactis);
• povidone (Povidonum);
• Magnesium Stearate (Magnesium stearate).

Product form

Afobazol is available in tablet form. The tablets are flat, cylindrical shape, with a facet, and 10 or 25 pieces in blisters. Their color can vary from white to white with a cream shade.

Also Afobazol tablets can be produced, packed on 30, 50 or 100 pieces in a jar with a polymeric cover.

Pharmacological action

Afobazol The drug belongs to the pharmacotherapeutic group anxiolytic   drugs.

Pharmacodynamics and pharmacokinetics

The active drug substance is a derivative of 2-mercaptobenzimidazole and is a selective nonbenzodiazepine trankvilizato R   ( anxiolytic ).

The drug does not stimulate the benzodiazepine receptors But has the ability to affect the sigma-1 receptors in the brain , Localized mainly in the areas responsible for memory, emotion, sensory perception and fine motor skills.

Afobazol has a stabilizing effect on the cell membrane receptor γ-aminobutyric acid , Thereby facilitating the restoration of sensitivity to inhibition of endogenous mediators .

In addition, Afobazol promotes bioenergy potential (BEP) nerve cells   and providing expressed neuroprotection And protects them from damage.

The drug has a dual effect on the human body, which is expressed as a combination of a sedative (antianxiety) and light stimulating effects.

It reduces the severity (or completely eliminates) the feelings of fear, somatic and autonomic manifestations of anxiety, emotional tension, irritability, relieves symptoms of post-traumatic stress disorders, withdrawal symptoms, as well as other specific conditions.

Especially it considered appropriate use of the drug in patients with severe asthenic traits that manifest themselves in the form of:

• suspiciousness;
• increased vulnerability;
• variability in mood;
• insecurity, etc ..

The drug prevents the occurrence of membranozavisimyh changes in the receptors With a sensitivity to GABA. The action is not accompanied by Afobazol gipnosedativny   and muscle relaxant effects . During treatment it is not marked deterioration of memory function, and impaired concentration.

The patient's condition improved, as a rule, in the fifth to seventh day of treatment. The maximum effect is observed after about three to four weeks after the first dose of pills and remained in effect for seven to fourteen days after discontinuation of the drug (depending on the individual characteristics metabolism   individual patient).

Afobazol well absorbed from GI . The drug has a high affinity to the cells of human body and a high degree of binding to plasma proteins .

The drug is excreted rapidly from the body, which significantly reduces the likelihood of an overdose of them. The average half-life of about 50 minutes.

Indications Afobazol

To understand what Afobazol appointed by the patient and what these pills do not help, you should consider the pharmacodynamic characteristics of the drug.

According to the summary, indications for use of this drug are:

• anxiety disorders, including mental disorders , Accompanied by a stable sense of anxiety that has no relation to specific objects or events,   asthenic neurosis Disorders of adaptive reactions (adjustment disorder);
• anxiety disorder due to a variety of dermatological . cancer . somatic   ( lupus . hypertensive disease . asthma . CHD . arrhythmia   etc.), and other diseases;
• anxiety disorders, have been reported with IRR   (in conjunction with other activities, as drugs for vegetative-vascular dystonia   It allows you to temporarily arrest the symptoms, but does not eliminate malfunctions Nervous System );
• sleep disorders resulting from increased anxiety;
• cardiopsychoneurosis   (NCD);
• symptoms cyclical syndrome   women (PMS);
• alcohol withdrawal   (alcohol withdrawal);
• withdrawal Arising from the failure of cigarettes.

Contraindications to Afobazol

Contraindications to Afobazol are:

• hypersensitivity or intolerance to the active substances or any of the ancillary components of the formulation;
• galactosemia (galactose intolerance);
• intolerance to monosaccharides   (glucose-galactose malabsorption);
• lactase deficiency   (lactase deficiency).

Also, the drug is contraindicated in children and adolescents under the age of 18 years old , Women during pregnancy   and women who breastfeeding .

Side effects Afobazol

Side effects often caused Afobazol individual intolerance to any component of the drug, and are expressed in the form of various kinds allergic reactions :

• itching of the skin ;
• dermatitis ;
• hives ;
• sneezing;
• rhinitis ;
• arteritis   etc.

Also not ruled out the probability of nausea . vomiting   and disorders of the chair . In rare cases, the side effect of a Afobazol headache Which does not require a specific treatment, change the dosage or drug withdrawal and runs independently.

Instructions for use Afobazol

In accordance with the instructions for use, Tablets Afobazol intended for ingestion. Before you take pills, you need to eat.

A single dose of the drug - 10 mg. The recommended instructions for use Afobazol daily dose - 30 mg. Take the pill should be in three stages (ie one tablet of 10 mg or 2 tablets of 5 mg per dose).

Since the maximum therapeutic effect of the drug develops only the beginning of the 4th week, the duration of their course of treatment is usually 2 to 4 weeks.

Before taking Afobazol, necessarily need to consult a doctor. This is due to the fact that certain conditions require increasing the dose and duration of treatment. Thus, according to the testimony of the daily dose may be doubled, and the rate of treatment extended to 3 months.

Overdose

Overdose Afobazol (meaning a significant excess of the therapeutic dose) provokes Sedation   and increased sleepiness, which is not accompanied by a reduction the tone of skeletal muscle tissue   and reduction in motor activity .

When symptoms of intoxication   Wikipedia recommends as an emergency patient subcutaneous injection 1 ml Caffeine-sodium benzoate   20% solution for injection. The drug should prick 2-3 times a day.

Cooperation

Afobazol has no effect on the deprimiruyuschie effect   ethyl alcohol and hypnotic (sleeping pill) action Thiopental sodium   (preparation for the inhalation anesthesia   -acting).

Potentiates the effect of antiepileptic Carbamazepine   and enhances the tranquilizing effect Diazepam .

Terms of sale

Over the counter.

Storage conditions

Keep the medication recommended in the original packaging of the reach of children at temperature not exceeding 25 ° C.

Shelf life

Usable for 2 years from date of manufacture. The use after the date printed on the package is prohibited.

Cautions

The drug has no effect on the ability to drive and use potentially dangerous machinery, so the answer to the question "Can I take the wheel Afobazol drug? "Positive.

Also it is not forbidden to take the means people employed in hazardous occupations and people whose work requires care and accuracy of responses.

Analogs Afobazol

Match code ATC 4th level:

• Anvifen
• Phenazepam
• Phenibut
• Stresam
• Noofen
• Tenotome

As with most other popular medications at Afobazol are analogues, that is, drugs similar to it in its pharmacological action, but different composition.

Analogues of the drug are: homeopathic remedy Tenotome . Grandaxinum . Stresam . Mebicar IC . Adaptol . Trankvilar IC .

Price Afobazol analogues varies depending on the manufacturer and the pharmacy. Adaptol For example, several Afobazol cheaper, but just as effective is characterized by low toxicity, it does not cause drowsiness and addiction withdrawal .

What is better - or tenoten Afobazol?

Tenotome   - A homeopathic drug having antidepressant . antiastenicheskim   and anti-anxiety action . Acting on localized predominantly in the cells of the nervous tissue   S-100 protein (a specific protein, responsible for the regulation of intracellular processes) preparation normalizes its functional activity.

As a consequence, respectively, in the body during normal metabolic processes As well as the mechanisms of activation and inhibition CNS . Tenotome   strengthens CNS , Improves memory and increases concentration and, moreover, increases the resistance to the effects of stress factors (including but not limited hypoxia   and intoxication ).

The main advantage of Tenotome   afobazole before is that it can be used as a treatment for adult patients and for the treatment of children (the drug is allowed to designate, starting with 3-hletnego age).

Another plus in favor of the Tenotome   - Is that the drug can be used as sedative , and how nootropics . This combination of properties in a single formulation avoids simultaneously receiving multiple drugs and thereby significantly reduce the pill burden on the patient and to minimize the likelihood of side effects.

Novopassit or Afobazol - which is better?

Novopassit   a sedative drug that is widely used to treat anxiety disorders   and conditions involving mental strain .

If Afobazol is a fully synthetic monocomponent preparation, the Novopassit   - A combination of seven different extracts of medicinal plants and guaifenesin.

Furthermore, unlike Afobazol Novopassit   has miorelaksiruyuschee   and gipnosedativny action .

Afobazol - it tranquilizer Which improves behavioral functions, improves mood and vitality of the body, reduces anxiety. The soothing effect , Which causes the drug, in this case is not the main and side.

Novopassit   The same applies to the group sedative drugs . That is already the name of its pharmacotherapeutic group it becomes clear that he has a pronounced calming effect.

Another difference preparations that appoint Novopassit Patients are allowed to 12 years of age and Afobazol - Only people who have reached 18 years of age.

Given all of the above, it is difficult to give a definite answer to the question of which of the drugs is better: they belong to different groups have different indications, as well as various forms of release (for example,   Novopassit available in tablet form and syrup whereas Afobazol - it only pill).

More correctly the comparison of characteristics such as security products, patient adherence to treatment (compliance), ease of administration, efficiency and price

Both drugs are considered safe, however, the probability allergies   and the reactions of intolerance at the reception Novopassita   in individuals with a history allergoanamnezom   and asthma , Slightly higher than the reception Afobazol.

In appointing Novopassita   also higher and the likelihood of unintended drug interactions (as the components it is much more than afobazole).

Assessing compliance preparations, we can say that here wins Novopassit . It includes only vegetable matter, which is a big plus (especially for seniors).

For ease of receiving competing drugs are roughly the same. The standard regimen of pills Afobazol - one tablet three times a day. Novopassit take two or three pills two or three times a day and two or three tablets just prior stress that is not absolutely not always convenient. However, it is Novopassit   a liquid form of release, which is preferable for many patients.

If you compare the price of drugs, there is definitely a Russian drug much cheaper.

With regard to efficacy, which, actually, is the main evaluation criteria for the majority of patients, everything depends on the individual characteristics of a particular organism, and accurately predict who would suit better, no one can.

What is better - or Grandaxinum Afobazol?

And Afobazol and Grandaxinum   used to treat the same ailments, relieve symptoms similar and are about the same price category.

Reviews of people who took on the testimony Grandaxinum   indicate that:

• the effect of the drug treatment is developing very fast, and the lasting effect is noted after only a few days after the first dose;
• the drug effectively relieves symptoms of nervous tension;
• tablets taste neutral, and reception means does not cause inconvenience and discomfort.

However, reception Grandaxinum   often provokes nausea Many patients also noted some lethargy and   dizziness Which have been especially pronounced when you change position.

Reviews afobazole lead to the conclusion that the latter:

• effective in anxiety states   and helps to cope with unpleasant symptoms PMS ;
• It is characterized as a low-toxic drug and has no significant side effects.

With strong stresses   drug, however, is ineffective. Also, it is almost useless in the treatment of insomnia . Panic Attacks   and deep depression . That is, it is advisable to assign it only in cases where the symptoms of anxiety   or stress   are not pronounced. In severe situations, the effective Grandaxinum .

So, the pros Grandaxinum   - Is its effectiveness with strong stresses   and expressed anxiety states And that its use is permitted even pregnant   women (it is contraindicated only in the first trimester pregnancy ). Less of it is that the drug causes more adverse reactions than its competitor - Afobazol.

What is better - or Persen Afobazol?

Compare Percy   and Afobazol correctly. This is due to the fact that drugs have a completely different structure and a different mechanism of action.

Persen   - It is completely herbal remedy that has a strong sedation And assigned to patients suffering from insomnia   and increased irritability .

The product facilitates falling asleep and relieves anxiety, but it has all the disadvantages and side effects that are inherent to its member medicinal plants.

Thus, during treatment Persenom   in some cases:

• sharply lower figures of blood pressure;
• developing addiction;
• reduced the effectiveness of treatment (sometimes only a few days after initiation of therapy);
• broken chair (particularly frequent constipation), etc.

Generally, Persen   quite difficult to name the drug in spite of the fact that the drug is able to quickly remove vasospasm , Has a relaxing and calming effect on the CNS , The cause of the symptoms it does not eliminate.

Afobazol as a tranquilizer   the point of action, which is realized through a combination of antianxiety and stimulant effects. Hypnotic effect, he is able to trigger only when the dose of the active substance exceed its mid-effective (ED50) at least 40 times.

After a course of treatment in patients Afobazol not only eliminated anxiety   and disappears depression , But also significantly improves memory and attention.

What is better - or Afobazol Adaptol?

Adaptol   prescribed for the treatment of moderately severe pain heart That are not associated with angina To eliminate the constant urge to smoke, neuroses Accompanied by fears . anxiety . irritability   and depression .

Also it is effective in the period Menopause At IRR   and conditions originating in the background oxidative stress . Adaptol   provides easy anxiolytic effect , Significantly reducing fears   and anxiety And, moreover, improves performance functional brain activity .

Upon receiving Adaptol   partially binds with the contained blood erythrocytes And partially - with proteins That allows it to spread rapidly in the body of the patient. So almost immediately after the last starting to feel peace and inner peace.

Action Adaptol   It is not accompanied by relaxation of the skeletal muscles and the change of motor function. The tool does not have a hypnotic, but has the ability to potentiate the effect of drugs prescribed to treat sleep disorders (which can be administered concurrently with these drugs).

As Afobazol, the drug has a very low toxicity. Adaptol  

  .     and .

  allergic reactions .

. . .

tranquilizers

  and .  

Beneath   and stresses .

.

  women.   hypothalamus Endocrine  

hormonal disorders .

  pregnancy .

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