Description overdue on 11/30/2014
- Latin name: Micrasim
- ATC code: A09AA02
- Active substance: Pancreatin (Pancreatin)
- Manufacturer: ABBA RUS, JSC (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacokinetics and pharmacodynamics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
As part of the means contains the active substance pancreatin in microgranules soluble in the intestine.
As additional substances in a preparation contains: triethyl citrate, eudragit (butyl methacrylate-dimethylaminoethyl methacrylate copolymer), simethicone emulsion, gelatin, talc, H2O, methyl parahydroxybenzoate, sodium lauryl sulfate, propylparaben, coloring agents, Titanium Dioxide.
Product form
Mikrazim available in capsule form. Solid gelatine capsules have a brown cap and transparent body. Inside the capsule contains spherical or cylindrical pellets of brown or light brown. They have a characteristic smell.
As capsules 10,000 IU and 25,000 IU capsules contained in blister packs 10, 20, 30 pieces.
Pharmacological action
Mikrazim - Is a drug belonging to a new generation of enzymatic means. It contains the active component pancreatin . This is a complex of digestive enzymes that are involved in digestion. As part of the pancreatin contained amylase . lipase . Protease . These pancreatic enzymes contribute to the process of assimilation in the body of carbohydrates, fats, proteins. As part of the capsule contains pancreatin pellets that look like minimicrospheres that are gastro-resistant. This effect is provided by a special coating to prevent exposure to gastric acid content. Consequently, the enzymes involved in the digestion of the drug during passage through the intestinal tract of food on gastric level these processes are not affected.
Pharmacokinetics and pharmacodynamics
Enzymes are released in the small intestine and contribute to active digestion, the normalization of these processes. After oral administration for several minutes, the capsule dissolves in the stomach and released minimicrospheres pancreatin. The effect after ingestion of capsules occurs in about 30-40 minutes. There is only the local effects of the drug in the gut it is not absorbed. Excreted in the feces.
Indications
Mikrazim appropriate to take in the following cases:
- As a substitution therapy for patients with pancreatic insufficiency (chronic inflammation of the pancreas, in cystic fibrosis, in tumors of the pancreas, after removal of the prostate).
- For the symptomatic treatment of disorders of the digestive processes ( gastritis with reduced acidity in the chronic form, function dyspepsia , Diseases of liver and biliary tract, and diseases of the colon or small intestine, where the broken evacuation function, after the removal of the gall bladder, stomach, intestines).
- In order to ensure the most active digestion process in sufficient GI function (overeating, eating high-fat foods, chewing dysfunction, prolonged immobilization).
- In the process of preparation for the integrated ultrasound or x-ray of the abdomen.
Contraindications
Do not take the drug if the patient says:
- intolerance pancreatin or its components;
- acute form of inflammation of the pancreas;
- acute stage of chronic changes of the pancreas.
Side effects
In most cases, the patients tolerate this remedy, but sometimes manifest some side effects. In such case the preparation needs to cancel or correct the dose.
Possible side effects such (they often develop in excess dosage of the drug)
- allergic reactions on the skin in the form rash . hives ;
- constipation ;
- diarrhea ;
- epigastric discomfort;
- nausea and vomiting ;
- elevated levels of uric acid in urine and blood.
There have been rare cases of fixed narrowing of the lumen of the intestine in patients with cystic fibrosis.
Instructions for use (method and dosage)
If the patient needs to take Mikrazim, instructions for use must be strictly observed them.
As the instructions for use, Mikrazim 10,000 should be in the process of eating or after eating. To wash down the capsule to be more fluid. You can not chew the capsule. If necessary, the contents of the granules can be mixed with food or liquid. This mixture should be swallowed without chewing.
Patients with cystic fibrosis children under 4 years of age is shown for each kilogram of 1000 U lipase. After four years of age, children should receive 500 IU of lipase per kilogram of body weight. Maximum tolerated dose - 10,000 U per kilogram body weight per 24 hours.
Diarrhea e and steatorrhoea whenever the use of food to be taken at 25,000 IU. Maximum permissible dose - 35,000 Units at one meal.
The highest tolerated dose for children 1 to 5 years - 50,000 lipase units per day. Those children who are over 1, 5 years, you can not take a day more than 100,000 units of lipase.
Overdose
If the dosage was significantly exceeded, possibly a manifestation of a tendency to constipation in children and hyperuricosuria and hyperuricemia. When such symptoms should be abolished drug use plenty of fluids and symptomatic treatment.
Cooperation
When you receive may decrease the absorption of Mikrazima folic acid Iron. The bioavailability of the drug is reduced if Mikrazim taken concurrently with antacids, which is composed of calcium carbonate and magnesium hydroxide.
Terms of sale
Mikrazim sold in pharmacies without a prescription.
Storage conditions
Keep capsules should be in the original packaging at a temperature not higher than 25 degrees.
Shelf life
You can store Mikrazim 2 years.
Cautions
It is necessary to closely monitor the health of a patient with a long reception Mikrazima.
Notes the decrease in the pharmacological effectiveness of the drug dysbiosis , Acidification of the contents of the small intestine, parasitic infestations . duodenostasis . Also, the effectiveness of tools is reduced if the drug is taken after the expiration date has expired.
If the drug is stored at high temperature, the activity decreases relatively rapidly minimicrospheres.
On the ability to focus, work with the precise mechanism to drive the medication has no effect.
When treating Mikrazimom need to drink plenty of fluids. You can not drink the capsule with alkaline liquids.
Analogs Mikrazima
Enzistal P
Pancreatin
Penzital
Pangrol
Ermital
Creon
Abomin
Festal
Mezim
Analogs of the drug Mikrazim - a drug that contains a similar active substance. This drug Likreaza . Gastenorm . Pankrenorm . Panzinorm . Pankreal . Pancrelipase . Pancreatin . Enzistal . Panzi and others. interchanged drugs only after consulting your doctor.
Babies
It is used to treat children in the appropriate dosage and only after the appointment of a specialist.
During pregnancy and lactation
During pregnancy means may be used if the benefit of treatment exceeds the probable risk. No data on the penetration of pancreatin into breast milk. During Lactation This tool can be used only after a doctor's appointment.
Reviews Mikrazime
Reviews Mikrazime often left those who noted a marked improvement when using this medication. It is noted that this tool not only helps in diseases of the pancreas and the digestive system, but also allows you to effectively overcome the unpleasant symptoms of overeating. Reviews of doctors indicate that Mikrazim should be used according to indications, as its uncontrolled intake may not produce the desired effect.
Price Mikrazima where to buy
Price Mikrazim 100,000 units on average of 150 rubles per 20 pieces. Price Mikrazim 250,000 units - 350-400 rubles per pack of 20 pieces.
No comments:
Post a Comment