Description overdue on 11/19/2014
- Latin name: Deprenorm MV
- ATC code: C01EB15
- Active substance: Trimetazidine (Trimetazidine)
- Manufacturer: Kanonfarma Production Company, Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Deprenorm
- Contraindications
- Side effects
- Instructions for use Deprenorm (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
One tablet contains 35 funds or 70 mg trimetazidine dihydrochloride + Extras ( microcrystalline cellulose, hydroxypropylcellulose, plasdon S-630, hydroxypropylmethylcellulose, polyethylene glycol, red iron oskid dihydrate calcium hydrogen phosphate, colloidal silicon dioxide, magnesium stearate, polyethylene glycol, talc ).
Product form
Deprenorm MW produced in the form of pink pills prolonged action biconvex film coated. If the tablet to break in half, shows two layers of a substance inside - white.
The drug is released in a dosage of 35 or 70 mg, 10 or 15 pieces of cellular packages contour, 2, 3, 4, 6 packs in the carton box.
Pharmacological action
Antihypoxia .
Pharmacodynamics and pharmacokinetics
The drug has antianginal and antihypoxic activity, improves metabolic processes in the myocardium .
The active substance increases aerobic glycolysis Inhibits oxidation polyunsaturated fatty acids Thus normalizing the oxygen consumption and activating reactions oxidative decarboxylation .
The drug inhibits the intracellular depletion ATP and phosphocreatine It normalizes contractility infarction It supports normal functioning potassium sodium channels. Conclusion CK of cells does not occur, Neutrophils in the zone of origin ischemia are not activated. Thus minimized myocardial damage due to ischemia.
The systematic use of frequency of attacks is significantly reduced as the patient's need Nitrates . Increases stamina, lost tinnitus and dizziness, improves the condition of the retina.
Upon receiving means active ingredient quickly into the systemic circulation, after absorption in the gastrointestinal tract. Its maximum concentration is achieved after 5 hours and 24 is maintained at 75% of maximum.
Man receives food with the medicine or not - does not matter, pharmacokinetic figures remain the same.
Conclusion preparation is the urine through the kidneys unchanged.
Indications Deprenorm
The drug is prescribed:
- at dizziness Arising as a result of vascular disorders;
- to prevent attacks angina as part of a treatment;
- at cochle-vetibulyarnyh disorders such as tinnitus, hearing problems, and so on., as a result of ischemia ;
- at chorioretinal vascular disorders .
It is also an indication for the use of funds is a vascular pathology of the eye, because the drug is able to improve the functioning of the retina.
Contraindications
The drug is contraindicated:
- at allergies on the components of the drug;
- at renal failure If KK is less than 15 ml per minute;
- children and adolescents (under 18 years);
- at pregnancy and breastfeeding ;
- liver diseases.
Side effects
The most likely adverse reactions: headache . dizziness . diarrhea , Nausea, asthenia Pain in epigastric region, vomiting, indigestion, constipation . itch , Skin rash, hives .
They may also occur: tremor , Hot flashes, palpitations, tachycardia , A strong decline Blood Pressure . agranulocytosis , Increased muscle tone, akinesia . beats . thrombocytopenia . agranulocytosis . hepatitis , Violation of motor activity, angioedema . drowsiness and insomnia .
Instructions for use Deprenorm (method and dosage)
The tablets are taken orally, regardless of the meal, washed down with plenty of liquid. The tablet should not be divided or bite.
The duration of the drug is determined by the doctor depending on the disease and its flow characteristics.
According to the instructions for use Deprenorm CF 35 mg, administered two tablets 2 times a day. If the dosage - 70 mg, it is drunk by 2 one tablet twice a day.
Overdose
In case of overdose should be made symptomatically.
Cooperation
Patients taking antihypertensive drugs, the drug can significantly reduce the pressure, until he lost consciousness.
Before taking this medication should consult with a specialist.
Terms of sale
It requires a prescription.
Storage conditions
In a dry place, in original packaging, at a temperature no higher than 25 degrees.
Shelf life
2 years.
Cautions
The drug is not a means of emergency requires a long systemic administration of the drug.
If there was an attack angina or heart attack Should see a doctor to review treatment.
The medicine may cause or worsen symptoms parkinsonism . When they occur, the drug should be discontinued, reconsider treatment. Symptoms usually go away within 4 months after drug withdrawal. If after that time the symptoms have disappeared, should be consulted Neurologist .
Analogs Deprenorm
Metamax
Tivortin Aspartate
Dibikor
Kardionat
Mexicor
Sulfokamfokain
Qudesan
Vero Trimetazidine
Preductal
Analogues: Preductal, Antistius, Mukofalk, Deprenorm, Medarum, Metegard, Vero Trimetazidine .
Reviews Deprenorm
Reviews of good preparation. Patients forget about attacks angina , Stop taking more toxic drugs, feel much better, normal exercise capacity. Adverse reactions are rare.
Price Deprenorm MB
Price Deprenorm CF 35 mg is about 200 rubles for 30 tablets.
The same amount of the drug at a dosage of 70 mg costs about 530 rubles.
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