Ksantinola nicotinate

Description overdue on 01.01.2013

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Vasodilators. The drug has properties of nicotinic acid and Drug Group theophylline:   improves collateral circulation Expands the lumen peripherally located vessels, has expressed antiplatelet effects , Strengthens the process of synthesizing ATP and oxidative phosphorylation. The principle is based on the exposure substrate stimulation of synthesis of NAD-phosphate and NAD, on increasing intracellular cAMP levels, by blocking phosphodiesterase   and adenosine receptors. Ksantinola nicotinate improves tissue nutrition, oxygenation, microcirculation . With prolonged use of notes increased activity of lipoprotein lipase, decreased concentration atherogenic lipids   and cholesterol processes activated fibrinolysis noted antiatherosclerotic effect Reduced platelet aggregation, reduced blood viscosity. The drug reduces the severity of the consequences of cerebral hypoxia increases cerebral circulation , Contributes to the IOC, increases myocardial contractility, reduces round. For drug characteristic "nikotinopodobny syndrome", which is shown acute sensitivity gustatory and olfactory sensations due to hypersensitivity of the mucous membranes of the oral and nasal cavities. Responses to the drug ksantinola nicotinate indicate a change in the taste and smell of alcoholic beverages during treatment. The drug is available as a solution in a tablet dosage form.

Indications:

Ksantinola nicotinate prescribed for Raynaud's disease, Buerger's disease   (thromboangiitis obliterans), with obliterating atherosclerosis   vessels of the extremities, with retinopathy, Meniere's syndrome , Migraine, bedsores, trophic ulcers of the lower leg, with postthrombophlebitic syndrome , Acute thrombophlebitis (with the defeat of the surface or deep vein thrombosis), diabetic angiopathy, cerebrovascular insufficiency, when skleredeme Buschke, scleroderma, stroke, atherosclerosis of brain vessels, when hypertriglyceridemia , Hypercholesterolemia, atherosclerosis of the coronary arteries during the post-natal and intrauterine fetal asphyxia, when dermatosis   Against the backdrop of trophism vascular origin.

Contraindications:

Ksantinola nicotinate not prescribed for glaucoma, severe renal pathology system during pregnancy, hypotension , Ulcers of the digestive tract in the acute stage, mitral stenosis, intolerance to the active substance, acute bleeding , The form of decompensated heart failure in acute heart failure, acute myocardial infarction.

Side effects, overdose:

Drug Usage ksantinola nicotinate indicate the following possible side effects: fever, drop in blood pressure, dizziness, stomachalgia , Decreased appetite, diarrhea, nausea, weakness, flushing of the skin. Application xantinol nicotinate in large doses over a long time leads to hyperuricemia , Increased liver enzyme levels, changes in glucose tolerance. If overdose is vomiting, epigastric pain , Drop in blood pressure. Recommended posindromnaya therapy.

Mode of application:

Ksantinola nicotinate used intramuscularly, intravenously (drip, bolus) or inside. Tablets are recommended to be swallowed whole. The dosage regimen:   three times a day at 150 mg. In some cases, the amount of the drug is increased to 300-600 mg (single dose). If the positive dynamics of the dose is gradually reduced. Duration of therapy is at least two months. Intramuscular   the drug is administered as a 15% solution of 2-6 ml for 2-3 weeks. Intravenously ksantinola nicotinate poured jet 1-2 times a day to 2 ml of a 15% solution (the patient has to lie down on the couch for the procedure). The duration of treatment 5-10 days. Intravenous drip injection is carried out at a speed of 40-50 drops / minute. Pre 10 ml of 15% of the drug is diluted in a solution of sodium chloride (0, 9% 200ml) or a dextrose solution (5% 200-500 ml). When diagnosing acute circulatory disorders of tissues besides parenteral administration simultaneously prescribed medicament in a tablet dosage form three times a day at 300 mg.

Special instructions:

Not to prescribe the drug ksantinola nicotinate in the first trimester of pregnancy. In the second and third trimester of drug use with careful monitoring of the patient. Prescription medications in large quantities can cause dizziness and falling blood pressure. Avoid getting ksantinola nicotinate on mucous membranes, eyes. Do not appoint drivers.

Drug Interactions:

Ksantinola nicotinate can not be used with MAO inhibitors . With extreme caution medication prescribed for concurrent therapy strofantinom   (There is a sharp increase in effect), antihypertensive drugs (sympatholytics, Alpha-blockers , Ergot alkaloids, beta-blockers, ganglioplegic).