Vesicare

Description overdue on 10/24/2014

• Latin name: Vesicare
• ATC code: G04BD08
• Active substance: Solifenacin (Solifenacin)
• Manufacturer: Dutch company «ASTELLAS PHARMA EUROPE, BV»

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Vesicare (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Reviews
• Price, where to buy

Composition

1 tablet contains 5 mg of medicament or 10 mg solifenacin succinate   depending on the form of.

Excipients: Mg stearate, hypromellose, starch, lactose.

Product form

The drug comes in the form of rounded, convex tablets with the logo of the issuing company on the one side coated light yellow color of Vesicare 5 mg and light pink at Vesicare 10 mg (depending on the concentration of the active substance). In a cardboard bundle is from 1 to 3 blisters of 10 pieces in each tablet.

Pharmacological action

Solifenacin   is a specific inhibitor of membrane proteins responsible for signal transmission in the neuromuscular synapse, the acetylcholine muscarinic receptors (m-cholinergic receptors). The drug has antispasmodic action and holinoliticheskoe   (reduces the tone of smooth muscles of the urinary tract). Solifenacin differs almost complete lack of affinity for other ion channels and receptors.

When using Vesicare observed cumulative effects - the maximum effect is registered after a month of reception and stored in the event of prolonged use (at least 1 year).

Pharmacodynamics and pharmacokinetics

When taken orally the time to reach C max (maximum concentration) of solifenacin plasma is 3-8 hours. Solifenacin is reacted with   plasma proteins   blood and contacting them for about 98%. These parameters are independent of the meal and the reception time. Also, there is no dependence on the sex and age of the patient. Patients with renal failure can occur to increase the maximum concentration of the active substance in the blood of 30%.

The drug is metabolized by the hepatic system. Excreted in the urine and feces, there is also an alternative way metabolism   (plasma were detected 4R-gidroksisolifenatsin, N-oxide, and other metabolites). Half-life of the drug is 45-68 hours.

Indications

The drug is used in the urgency (irresistible) incontinence .   nocturia   and frequent urination That is typical for overactive bladder syndrome .

Contraindications

• heavy gastrointestinal diseases ;
• hepatic failure   in severe and terminal forms;
• renal insufficiency (including when receiving inhibitors CYP3A4);
• hemodialysis ;
• myasthenia gravis ;
• urinary retention ;
• closure form Glaucoma ;
• hypersensitivity   or intolerance to the components of the drug;
• childhood and adolescence;
• galactosemia and lactose deficiency.

No data on the effect of the drug on the body under the age of 18 years. There are no contraindications for the elderly. Be wary of pregnancy   and Lactation .

Side effects

Frequently observed:

• constipation ;
• urge to vomiting and nausea;
• epigastric pain;
• accommodation disturbances ;
• dryness of the oral cavity and pharynx;
• urinary retention;
• dry eyes;
• drowsiness ;
• dryness of the nasal cavity and skin;
• lower extremity edema ;
• fatigue.

Rarely are recorded:

• ileus ;
• dizziness , Mild retardation and headache ;
• Acute ischuria   (urinary retention);
• vomiting;
• hallucinations ;
• drowsiness;
• allergic responses   ( itch . rash . hives ).

Instructions on Vesicare (method and dosage)

The drug is administered orally, drinking plenty of fluids 1 tablet with a concentration of solifenacin 5 mg 1 time per day. According to the testimony of the dose up to 10 mg. Receiving drugs can be, regardless of time of day, and meals.

Instructions for use Vesicare points to the possible impact of the active substance on the quality of vision and the work of the CNS. Do not take the medication when dealing with complex mechanisms, the management of transport.

Overdose

When receiving a one-time 100 mg of solifenacin may experience headache, weakness, dry mouth, mild dizziness,   blurred vision . Cases of acute overdose are not registered.

In case of overdose shows reception Activated Carbon . It may be necessary gastric lavage But without calling emesis. Further treatment is symptomatic.

Cooperation

When concomitantly with drugs that block m-holinretseptory observed more pronounced therapeutic effect. M-cholinomimetics   reduce medicinal effect of solifenacin. The drug can affect the action of drugs that stimulate the motility of the digestive system.

Terms of sale

Sale with a prescription.

Storage conditions

The drug must be kept out of reach of small children at room temperature (not more than 25 ° C).

Shelf life

With proper storage is 3 years.

Cautions

Before you assign the drug should establish the existence of other possible causes urination disorders ( infections of the genitourinary system , Kidney and ureter, heart failure ). Upon detection of infections of the genitourinary system should be carried out antimicrobial treatment   before taking this medicine. It should take the drug with care when dealing with vehicles and occupation of hazardous activities.

Analogs of Vesicare

Match code ATC 4th level:

• Driptan
• Urotol
• Spazmeks

Structural analogs have not been developed. Medicines with a similar mechanism of action:

• Driptan
• Spazmeks
• Uro-Vaks
• Urotol

Price analogues varies from 300 to 500 rubles.

Reviews of Vesicare (opinion of the patients)

Reviews of Vesicare medical topics in the forums indicate that the drug was not able to establish itself as the most highly effective in combating the problem of urinary incontinence. Most of the stories of patients do not report the occurrence of relief after taking the drug. Also, many users have reported incidence of adverse effects.

However, data are available when the best result among peers was observed after administration of Vesicare; when other medicines do not help. It is important to remember that the treatment of overactive bladder syndrome is complex, and depends largely on the personality of each individual organism.

Price Vesicare where to buy

The cost of the drug in Russian pharmacies varies from 1200 to 1550 rubles per 30 tablets. Price Vesicare may vary by region sales and pharmacy chain.

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