Description overdue on 05.06.2014
- Latin name: Klion-D 100
- ATC code: G01AF20
- Active substance: Metronidazole (Metronidazole), miconazole (Miconazole)
- Manufacturer: Of Gedeon Richter, Hungary
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Klion D-100 (Method and Dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One suppository contains 0, 1 g of active substance metronidazole + miconazole nitrate 0, 1 g + auxiliary substances ( silica, povidone, tartaric acid, sodium lauryl sulfate, magnesium stearate, sodium bicarbonate, sodium carboxymethyl hypromellose, lactose, crospovidone, starch ).
Product form
Vaginal candles in white strips of 10 candles in cartons of 1 Strip.
Pharmacological action
Antibacterial, antiprotozoal and antifungal agent Used in the gynecology.
Pharmacodynamics and pharmacokinetics
The action of the drug is due to a complex influence on the vaginal microflora , Its constituent components.
Miconazole - Anti-fungal agent that disrupts dermatophytes and yeasts But not penalized pH and does not destroy healthy microflora in the vagina. Agent directly affects the synthesis of lipidnyh components a fungus membrane, thereby destroying it. Does not penetrate into the blood and is not detected in the kidney and isolation of the products, 90% remains in the vagina. Maximum concentration - 8 hours.
Metronidazole - antibiotic . It inhibits the process synthesis RNA and DNA pernicious bacteria by reduction of 5-nitro transport proteins intracellularly. After entering the vagina, into the blood. Its maximum concentration in blood (half of the administered dose) may be detected after 9 hours.
Indications
From what is prescribed Klion D-100?
- from thrush ;
- treatment vaginitis Which were caused by bacteria Trichomonas spp. and fungus Candida spp.
Contraindications
The drug should not be used in 1 trimester of pregnancy and breastfeeding, and for children.
It is also possible to use funds for patients drug allergies the drug components, with liver diseases, central nervous system and leukopenia .
Side effects
- discomfort, burning and itching at the mucosa;
- vomiting, constipation or diarrhea, nausea, a metallic taste in the mouth ;
- dizziness, leukocytosis and headache;
- Urine may become red-brown color, skin rash appears.
Instructions for use Klion D-100 (Method and Dosage)
The duration of administration and dosage of the drug should be prescribed by a doctor, depending on the course and severity of the disease.
According to the instructions on the candle Klion D-100, one candle is administered at night for 10 days. Before use, wetted with a little water. As a general rule, prescribe additional tablets Clione .
Overdose
Symptoms of overdose are nausea, vomiting and other manifestations of reinforced side effects. In case of contact of the drug into the digestive system worth produce gastric lavage , Reception enterosorbents and hemodialysis .
Cooperation
The drug is not combined with ethanol, disulfiram . non-depolarizing miorelaxanthami , Cimetidine, lithium preparations .
At simultaneous reception anticoagulants Worth an additional monitor prothrombin index .
The efficacy of metronidazole in combination with reduced phenobarbital and phenytoin .
Terms of sale
It requires a prescription.
Storage conditions
In a dark, cool, the children, temperature up to 30 degrees.
Shelf life
5 years.
Cautions
The use of candles during menstruation should be agreed with your doctor. Typically, during menstruation should take a break and continue after the end of menstruation.
Analogs
Ginalgin
Lomeksin
Ornidazole Vero
Neo-Penotran
Gyno-Pevaril
Livarol
Ginezol
Antifungol
Candide
Ginofort
Trichopolum
Flagyl
Analogues of candles are: Metromikon-Neo Ginalgin, Klomezol, Neo-Penotran Forte Klevazol, Pulsiteks, Kandibene, Ketodin, Candide, ketoconazole, Livarol, metronidazole, clotrimazole, Trichopolum, econazole.
What is the difference and Clione Clione D-100?
Tablets contain Clione metronidazole and have a wider range of applications. Typically, to combat trichomoniasis oral tablets alone is insufficient, causing administered candles Klion D-100.
With alcohol
Not compatible.
During pregnancy and lactation
Clione D during pregnancy in 1 trimester is contraindicated. Sometimes appointed candles during pregnancy in 2 and 3 trimester, under the supervision of a physician. Due to the fact that a significant portion of metronidazole is excreted in breast milk, breast-feeding should be discontinued.
Reviews about the Klion-D 100
Reviews Online: On the whole, good. Many applied Klion D-100 from thrush and we were satisfied with the result. Some women complain of a strong manifestation of the side effects. The preparation is quite effective not only from yeast, but also from other species vaginitis .
Reviews in pregnancy: Despite the fact that the application means during pregnancy is not recommended for women often administered candles. Reviews for candles Klion-D 100razdelilis, some women taking the drug was well tolerated, and it had no effect on their children. Many also experienced a strong burning sensation, itching, abdominal pain and willfully stopped taking the drug.
Price Klion D-100 (Where to buy)
The average price of candles Klion D-100 in Ukraine is 100 UAH for 10 vaginal tablets.
What is the cost to buy the medicine in Kiev? About 120 USD for 10 pieces.
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