Description overdue on 09/15/2014
- Latin name: Adenorm
- ATC code: G04CA02
- Active substance: Tamsulosin hydrochloride (Tamsulosin hydrochioride)
- Manufacturer: Kiev Vitamin Plant (Ukraine)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Adenorma (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Reviews
- Price, where to buy
Composition
The active ingredient of the drug - tamsulosin hydrochloride .
Additional ingredients: sugar spherical, hydroxypropylmethylcellulose, hypromellose phthalate, diethyl phthalate, ethyl cellulose, povidone, cetyl alcohol, talc.
The hard gelatine capsule also includes the following substances: gelatin, iron oxide yellow, indigotine dye, red iron oxide, titanium dioxide.
Product form
Hard capsules.
Pharmacological action
The drug is used for prostatic hyperplasia (benign).
Pharmacodynamics and pharmacokinetics
Adenorm referred to alpha1-adrenergic antagonists Which are located in the prostatic urethra, prostate smooth muscle, as well as in the neck and body of the bladder. Which reduces the tonus of the prostatic urethra smooth muscles of the prostate and bladder neck. In addition, improved function detrusor Less symptoms of obstruction and irritation due prostatic hyperplasia .
Efficacy visible two weeks after the start of the reception, with a decrease in symptoms of the disease can be seen after the first day of the course.
Pharmacokinetics is characterized by linearity. Adenorm rapidly absorbed from the gastrointestinal tract. Maximum plasma concentration after a single use dosages of 0, 4 mg (one capsule) is achieved after 6 hours. Enough strong bond with plasma proteins.
The drug is slowly broken down in the liver to inactive metabolites . The main part of the active ingredient present in unchanged form.
Half-life during single administration in dosages 0, 4 mg (one capsule) - 10 hours, with prolonged use - 13 hours. Write mainly in the form metabolites urine, only about 9% is excreted unchanged.
Indications
Indications Adenorma: the need for the treatment of disorders of the lower urinary tract in the presence of prostatic hyperplasia (benign).
Contraindications
The medicine should not be taken with the heightened sensitivity to its components. And in severe hepatic insufficiency . orthostatic hypotension (even in history), and in children.
Side effects
When using this tool, the following side effects:
- Central nervous system: headache . dizziness .
- Respiratory mediastinal disorders: rhinitis .
- Skin and mucous membranes: rash . itch . hives .
- CCC: orthostatic hypotension . palpitations .
- General disorders: asthenia .
In addition, in rare cases, fainting marked, constipation . nausea . diarrhea . vomiting . angioedema . Stevens-Johnson syndrome . retrograde ejaculation . priapism .
There are a few cases intraoperative instability iris in step due Cataract in patients taking a long time funds from tamsulosin as the active substance.
Instructions for use Adenorma (method and dosage)
The drug is intended for oral administration. Instructions for use Adenorma advises to wash down the tool with plenty of water. Admission is designed for the morning. Capsules not chew. The daily dosage - 1 capsule.
Overdose
In overdose possible a sharp decline in blood pressure . In this case it is necessary to conduct maintenance therapy to the normalization of the CCC. In addition, in some cases, allowed to carry out infusion therapy and take vasopressor agents . It is imperative to follow the work of the kidneys and, if necessary, to carry out general maintenance therapy.
It allowed induce vomiting. If a large overdose gastric lavage is performed, shall be appointed and laxatives Activated carbon .
Cooperation
The combination of funds from other alpha 1-blockers can strengthen hypotensive effect .
Together with Cimetidine Adenorma concentration of active substance increases, and with Furosemide Conversely, lowered. Its level, however, remains within the normal range, so that the correct dosage is needed.
Diclofenac and Warfarin may somewhat increase the rate of elimination from the body Adenorma.
Together with strong CYP2D6 inhibitors and CYP3A4 higher doses of the drug will not be tolerated or accepted with caution.
Terms of sale
The drug is released in pharmacies with a prescription.
Storage conditions
Keep Adenorm necessary only in the original packaging in a place not accessible to children. Optimum temperature - not more than 25 ° C.
Shelf life
Shelf life - 3 years.
Reviews Adenorme
Reviews of doctors Adenorme mostly positive. Urologists prescribe it after the analysis of indicators Ultrasound prostate and PSA blood . The drug is allowed only if there are appropriate indications for use.
Reviews Adenorme patients are left mostly good. Some, however, note certain side effects. For example, such as retrograde ejaculation . However, all comments about Adenorme agree on the fact that the positive effect is noticeable after two weeks.
Many also wrote that the price Adenorma relatively affordable. This largely explains the great demand for this tool. In the forums it is often confused with the common remedy for pressure BP Norm But to find in shops right tool is not a problem. Patients say that the price Adenorma some sites even lower than in pharmacies.
Price Adenorma where to buy
The cost of the drug an average of about 140 UAH.
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