Description overdue on 11/11/2014
- Latin name: Yaz Plus
- ATC code: G03AA12
- Active substance: Drospirenone + Ethinylestradiol + calcium levomefolinat
- Manufacturer: Bayer Schering Pharma AG (Germany)
- Composition
- Product form
- Pharmacological action
- Pharmacokinetics and pharmacodynamics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Part Jess Plus (active tablets) contains active ingredients Drospirenone . ethinylestradiol clathrate betadeks . calcium levomefolat .
The structure also includes additional components lactose monohydrate, croscarmellose sodium, magnesium stearate, giproloza.
The composition contains an auxiliary tablets calcium levomefolat active component and the additional ingredients are lactose monohydrate, croscarmellose sodium giproloza magnesium stearate.
Product form
Available in tablet form. Active tablets are biconvex, round shape, their covers pink film coating. On one side of the tablet there engraving «Z +» a hexagon.
Auxiliary tablets are biconvex, round shape, their covers Orange film coating. On one side of the tablet has engraved "M +" in the hexagon.
The contour pack contains 24 active pills and 4 tablets support. In a cardboard box - one blister.
Pharmacological action
Jess Plus tablets are low-dose monophasic oral estrogen-progestin contraceptive Which includes the active pills, tablets and additional, which is composed of calcium levomefolat.
The contraceptive effect of funds is achieved by suppressing ovulation and increase the level of viscosity of the cervical mucus.
Women who take such drugs indicate that their menstrual cycle gradually becomes more regular, and in the days of menstrual pain and reduces the intensity of the discharge. As a consequence, while taking the drug in women reduces the risk of iron deficiency and anemia . There is also information that reduces the risk of vehicle endometrial cancer and ovary .
Substance Drospirenone Which is contained in the composition of this contraceptive, it has on the body antimineralokortikoidnym influence prevents fluid retention in the body, connected with hormone-dependent. The substance provides an antiandrogenic activity, which in turn provides an improvement of a acne , Improving the condition of hair and skin.
Effects drospirenone similar effects progesterone That is produced naturally in a woman's body. This should be taken into account those who chooses a means of contraception.
Substance Calcium levomefolat - Biologically active form of folate. This component is absorbed by the body more active than folic acid . When taken regularly levomefolata foliatah satisfies the need for the female body.
If there is a calcium levomefolata oral contraceptive in women taking this drug, reduced risk of neural tube defect manifestation fetal unexpected pregnancy. This woman just found out about the pregnancy, should immediately stop taking the tablets Jess Plus.
Pharmacokinetics and pharmacodynamics
Drospirenone ingestion rapidly absorbed, once when receiving the highest concentration in the blood was 1-2 hours. The level of bioavailability is 76-85%. Ingestion bioavailability means not affected. Displays in the form of metabolites kidneys and gastrointestinal tract.
Ethinylestradiol completely and rapidly absorbed after oral administration. The highest concentration of the drug is achieved within 1-2 hours. His level of bioavailability is approximately 60% after oral administration. If used at the same time food, the bioavailability of the substance is reduced by 25%. Excreted as metabolites via the kidneys gastrointestinal tract. The half-life - about 24 hours.
Levomefolat calcium is absorbed in the body quickly, it is included in the pool of folates. After receiving biphasic pharmacokinetics observed: there is a pool with a fast and a slow metabolism. Displayed in an unmodified form or in the form of metabolism via the kidneys and digestive system.
Indications
The pill Jess Plus displays as a contraceptive to women who have celebrated hormone-dependent fluid retention . Also used for contraception for women who need a moderate form of therapy acne . Plus, Jess shows how a contraceptive for women in the body that there is a lack of folate. Also shown is the women with severe symptoms PMS .
Contraindications
Contraindicated use of birth control pills Jess Plus, women who have observed such diseases and conditions of the body:
- intolerance of components means or hypersensitivity to it;
- thrombosis , Thromboembolism (in history, in the current period);
- conditions that precede the development of thrombosis (history in the current period);
- there are several factors that increase the risk of thrombotic events;
- migraine In which the marked neurological symptoms;
- diabetes In which the patient present vascular complications;
- severe liver disease, including - hepatic failure, liver tumors (benign or malignant);
- acute renal failure or severe;
- cancers associated with hormone-dependent and suspected development of such units;
- vaginal bleeding, reasons for which are unclear;
- pregnancy and breast feeding ;
- lactose intolerance associated with heredity.
If any of the above conditions or diseases are already evident when taking a contraceptive, should immediately stop taking Jess Plus.
Precautions should be taken of these birth control pills, if the woman is such a disease or condition:
- the presence of factors that increase the risk of symptoms of thromboembolism, thrombosis ( excess weight , Smoking, hypertension, hereditary predisposition to thrombosis, migraine, and others.);
- diseases in which may develop disorders of peripheral blood flow;
- hypertriglyceridemia;
- liver disease;
- disease, development or exacerbation of which was noted for the first time during pregnancy or in the treatment of sex hormones;
- postpartum period.
Side effects
When receiving Jess Plus may experience the following side effects:
- nausea, pain in the breast, the appearance of recurrent bleeding from the genital tract;
- migraine;
- depression , mood swings.
In rare cases, there are side effects:
- decrease in sex drive;
- thromboembolism;
- erythema multiforme;
- tumor;
- increase Blood Pressure ;
- hypertriglyceridemia;
- dysfunction of the liver;
- chloasma;
- allergic reactions .
Instructions for use (method and dosage)
If a woman chooses, as a means of contraception Jess Plus, instructions for use should it be carefully observed.
Instructions on Jess, plus provides oral tablets in accordance with the procedures indicated on the product packaging. A woman should know exactly how to take the tablets: they do not need to chew, you need to drink a small amount of liquid. You should try to use the tablet at about the same time.
Daily for 28 days, it should drink 1 tablet. Once the completed package, you should immediately open the next one.
Start taking the pill should be the first day of the menstrual cycle, ie the first day of bleeding.
If a woman says diarrhea or vomiting, the drug due to such disorders of the body can not fully absorbed, thus need more contraceptive protection during this period.
After Menopause Tablets should not apply.
Overdose
There is no information about overdose Jess Plus. In this case, perhaps a manifestation of nausea, vomiting, and spotting. It is shown in this case, symptomatic therapy. Calcium levomefolat well tolerated.
Cooperation
If both is receiving oral contraceptives and other drugs likely manifestation of uterine bleeding or reduce the impact of contraceptive pills.
In simultaneous treatment with drugs that induce hepatic microsomal enzymes, growth is possible clearance of sexual hormones.
Upon receipt of a number of antibiotics ( penicillins . tetracycline ) May decrease the enterohepatic recycling estrogen . As a consequence of reduced concentrations of ethinyl estradiol.
If a woman takes medicines that affect the liver microsomal enzymes, that at this time, and for 28 days after the termination of such treatment is necessary to use additional means of contraception.
During treatment with antibiotics and for one week after their withdrawal need to use additional contraception (exception - Rifampicin . Griseofulvin ).
When taking certain medications can decrease the effectiveness of calcium levomefolata. It Trimethoprim . Methotrexate . Sulfasalazine . Triamterene . Hlestiramin . Phenytoin . Carbamazepine . Primidone . Phenobarbital and etc.
Folate alter the pharmacokinetics or pharmacodynamics of a number of medicines.
Terms of sale
Pharmacies Jess Plus is sold on prescription.
Storage conditions
The tool should be stored at a temperature of not more than 25 ° C. It is necessary to protect the tablet from the reach of children.
Shelf life
Store can be 5 years
Cautions
It is necessary to compare the level of risk and benefit in the presence of certain diseases in women are going to use Jes Plus for contraception.
Receiving agents may mask the presence of deficiency in the body B12 .
If there was a skipping pills, then for 24 hours decrease contraceptive effect is not observed. Drink pill should immediately after the woman about this recall. Even if at the same time you will have to take two tablets missed tablet should not be ignored. More than two tablets a day can not be taken.
If the woman missed tablets, and during the use of inactive pills she has no bleeding, you should take a pregnancy test.
In the process of receiving Jess Plus may be a manifestation of bleeding. This usually occurs in the first months of receiving the funds.
Jess Plus does not provide protection against HIV infection and sexually transmitted diseases.
Plus, Jess has no attention to the severity of psychomotor reactions.
Analogs Jess Plus
Femoden
Jess
Zoeli
Dimia
Mersilon
Lindinet
Miniziston
Silest
Rigevidon
Yarina
Analogs of the drug Jess Plus - a contraceptive Midian . Jess . Dimia . Yarina Exerted on a woman's body like effect. Despite the fact that the impact of all these tools is similar, it is desirable that a woman doctor contraceptive picked individually.
Babies
The drug is not administered to children and teenage girls can take Jess Plus only after menarche.
With alcohol
Combining Jess Plus and alcohol, women often fear that the impact of contraceptive pill may be reduced. Experts note that alcohol in small doses does not reduce the contraceptive effect of the tablets. But when taking oral contraceptives is prohibited to abuse alcohol. With an overdose of alcohol must also use other means of contraception
During pregnancy and lactation
During pregnancy, you can not take pills. If a woman using birth control with Jess Plus and pregnancy yet occurred, you must immediately stop taking the contraceptive drug. In this case, the pregnancy continues to develop normally. When lactation Jess Plus is also contraindicated since pills can change the composition of the milk or affect its quantity.
Reviews of Jess Plus
Doctors about Jess Plus, usually positive, as experts note the high contraceptive efficacy, as well as the fact that the side effects when taking evolve relatively rare. Women taking pills Jess Plus, the reviews also left mostly positive. There easy dosing efficiency. But in some cases, still it says that after a few days of taking the pills developed nausea, headache, mood swings. If non-compliance with the proper dosage regimen means advancing pregnancy after Jess Plus, reviews women testified that later the fetus develop normally.
Price Jess Plus, where to buy
Buy contraceptive medication at any pharmacy. Price Jess Plus pharmacies averaged 900 rubles per pack.
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